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郭濱

細(xì)胞器應(yīng)激與組織再生課題組

電話：021-63846590-776936

郵箱：[email protected]

本課題組的主要研究興趣是細(xì)胞器應(yīng)激在疾病發(fā)生與組織再生中的功能及調(diào)控機(jī)制。我們的研究體系包括小鼠和人的造血干細(xì)胞,、白血病干細(xì)胞,；聚焦的科學(xué)問題包括線粒體應(yīng)激與造血干細(xì)胞再生以及白血病的發(fā)生與發(fā)展,；內(nèi)質(zhì)網(wǎng)應(yīng)激與造血干細(xì)胞命運(yùn)決定,；核仁應(yīng)激與造血及骨髓再生,；人類造血干細(xì)胞體外擴(kuò)增小分子藥物篩選及其衍生細(xì)胞產(chǎn)品開發(fā),。我們的研究對于各種惡性或非惡性血液系統(tǒng)相關(guān)疾病的治療具有重要意義,。

郭濱,，生物化學(xué)與分子生物學(xué)博士，上海交通大學(xué)基礎(chǔ)醫(yī)學(xué)院病理生理系、細(xì)胞分化與凋亡教育部重點(diǎn)實(shí)驗(yàn)室研究員,、博士生導(dǎo)師,；入選國家海外高層次人才計(jì)劃青年項(xiàng)目，上海市海外高層次人才特聘專家,、東方學(xué)者特聘教授,。主持國家重點(diǎn)研發(fā)計(jì)劃“干細(xì)胞及轉(zhuǎn)化研究”青年項(xiàng)目、國家自然科學(xué)基金重大研究計(jì)劃培育項(xiàng)目,、國家自然科學(xué)基金面上項(xiàng)目等,。相關(guān)研究成果發(fā)表在Nature Medicine、Nature Cell Biology,、Journal of Clinical Investigation,、Leukemia、Nature Communications,、Autophagy,、EMBO Reports等期刊上。

1. Jin Y*, Wang Q*, Ding Q*, Yao C, Jiang R^#, Guo B^#, Meng Q^#. H6PD overexpression promotes ex vivo expansion of human cord blood hematopoietic stem cells. Stem Cell Reviews and Reports. (2022). https://doi.org/10.1007/s12015-022-10352-w (#Corresponding author)

2. Chen Y*, Fang S*, Ding Q*, Jiang R*, He J, Wang Q, Jin Y, Huang X, Liu S, Capitano ML, Trinh T., Teng Y^#, Meng Q^#, Wan J^#, Broxmeyer HE^#, and Guo B^#. (2021). ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress. J. Clin. Invest. 131(20):e148329. doi: 10.1172/JCI148329. (#Corresponding author)

3. Jin Y*, Huang J*, Wang Q, He J, Teng Y, Jiang R^#, Broxmeyer HE^#, Guo B^#. RXR Negatively Regulates Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem and Progenitor Cells. (2021). Stem Cell Reviews and Reports. 17(4):1456-1464. https://doi.org/10.1007/s12015-021-10124-y (^#Corresponding author)

4. Chen Y*, Yao C*, Teng Y, Jiang R, Huang X, Liu S, Wan J, Broxmeyer HE^#, Guo B^#. (2019). Phorbol ester induced ex vivo expansion of rigorously-defined phenotypic but not functional human cord blood hematopoietic stem cells: a cautionary tale demonstrating that phenotype does not always recapitulate stem cell function Leukemia 33:2962-2966. (^#Corresponding author)

5. Huang X*, Guo B*, Liu S, Wan J, Broxmeyer HE. (2018). Neutralizing negative epigenetic regulation by HDAC5 enhances human hematopoietic stem cell homing and engraftment. Nature Communications 9:2741. (*Co-first author)

6. Guo B*, Huang X*, Lee MR, Lee SA, Broxmeyer HE. (2018). Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nature Medicine 24:360-367. (*Co-first author)

7. Guo B, Huang X, Cooper S, Broxmeyer HE. (2017). Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment. Nature Medicine 23:424-428 (Top Story of Cell Therapy News 18.07 March 6, 2017; Top Story of Cord Blood News 9.09 March 9, 2017).

8. Guo B*, Liang Q*, Li L, Hu Z, Wu F, Zhang P, Ma Y, Zhao B, Kovas AL, Zhang Z, Feng D, Chen S, Zhang H. (2014). O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation. Nature Cell Biology 16:1215-1226. (*Co-first author)

9. Guo B*, Huang X*, Zhang P, Qi L, Liang Q, Zhang X, Huang J, Fang B, Hou W, Han J, Zhang H. (2014). Genome-wide screen identifies signaling pathways that regulate autophagy during C. elegans development. EMBO reports 15:1001-1102. (*Co-first author)

10. Guo B*, Huang J*, Wu W, Feng D, Wang X, Chen Y, Zhang H. (2014). The nascent polypeptide-associated complex is essential for autophagic flux. Autophagy 10:1738-1748. (*Co-first author)

11. Zhang H, Chang J, Guo B, Hansen M, Jia K, Kovacs AL, Kumsta C, Lapierre LR, Legouis R, Lin L, Lu Q, Melendez A, O’Rourke AJ, Sato K, Sato M, Wang X, Wu F. (2015). Guidelines for monitoring autophagy in C. elegans. Autophagy. 11:9-27.

12. Lu Q, Yang P, Huang X, Hu W, Guo B, Wu F, Lin L, Kovács AL, Yu L, Zhang H. (2011). The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes. Developmental Cell 21: 343-357.