課題組名稱 疾病標(biāo)志物超靈敏檢測(cè)
研究組長(zhǎng)介紹
郵箱：[email protected]
王旭，博士，本科和碩士畢業(yè)于大連理工大學(xué)，師從于生物化學(xué)專家彭孝軍院士。博士畢業(yè)于德國(guó)慕尼黑工業(yè)大學(xué)，師從于歐洲著名分析化學(xué)家Reinhard Niessner教授。2017年到2021年為美國(guó)哈佛大學(xué)助理研究員，合作導(dǎo)師為美國(guó)三院院士、Illumina創(chuàng)始人 David R. Walt 教授。王旭博士在 JACS、Chemical Science 等著名刊物發(fā)表多篇一作論文，并申請(qǐng)多項(xiàng)國(guó)際專利，擔(dān)任Frontiers in Chemistry客座副主編。
課題組致力于超靈敏檢測(cè)技術(shù)的開(kāi)發(fā)，檢測(cè)蛋白質(zhì)、酶、核酸、小分子等疾病標(biāo)志物，并搭建配套的檢測(cè)儀器，用于癌癥、心血管疾病、神經(jīng)退行性疾病的早檢和診斷。
主要研究方向如下：
1.開(kāi)發(fā)超靈敏、高通量的單分子免疫分析檢測(cè)疾病標(biāo)志物
2.開(kāi)發(fā)超靈敏的方法檢測(cè)酶活性，并用于單細(xì)胞分析和藥物篩選
3.開(kāi)發(fā)新型熒光檢測(cè)方法，用于細(xì)胞和組織內(nèi)的蛋白質(zhì)、酶、RNA、活性氧等的成像
代表性論文：
1.Xu Wang, Alana F. Ogata and David R. Walt. Ultrasensitive Detection of Enzymatic Activity Using Single Molecule Arrays. J. Am. Chem. Soc. 2020, 142, 15098–15106.
2.Xu Wang and David R. Walt. Simultaneous Detection of Small Molecules, Proteins and microRNAs Using Single Molecule Arrays. Chem. Sci. 2020, 11, 7896-7903.
3.Xu Wang, Limor Cohen, Jun Wang and David R. Walt. Competitive Immunoassays for the Detection of Small Molecules Using Single Molecule Arrays. J. Am. Chem. Soc. 2018, 140, 18132-18139.
4.Xu Wang, Feng Li and Yirong Guo. Recent Trends in Nanomaterial-Based Biosensors for Point-of-Care Testing. Front. Chem. 2020, DOI: 10.3389/fchem.2020.586702.
5.Xu Wang, Reinhard Niessner, Dianping Tang and Dietmar Knopp*. Nanoparticle-Based Immunosensors and Immunoassays for Aflatoxins. Analytica Chimica Acta, 2016, 912, 10-23.
6.Xu Wang, Fengling Song,* and Xiaojun Peng. A Versatile Fluorescent Probe for Imaging Viscosity and Hypochlorite in Living Cells. Dyes and Pigments, 2016, 125, 89-94.
7.Xu Wang, Jutta Pauli, Reinhard Niessner, Ute Resch-Genger and Dietmar Knopp*. Gold Nanoparticle-Catalyzed Uranine Reduction for Signal Amplification in Fluorescent Assays for Melamine and Aflatoxin B1. Analyst, 2015, 140, 7305-7312.
8.Xu Wang, Reinhard Niessner and Dietmar Knopp*. Controlled Growth of Immunogold for Amplified Optical Detection of Aflatoxin B1. Analyst, 2015, 140, 1453-1458.
9.Xu Wang, Reinhard Niessner and Dietmar Knopp*. Magnetic Bead-Based Colorimetric Immunoassay for Aflatoxin B1 Using Gold Nanoparticles. Sensors, 2014, 14, 21535-21548.
團(tuán)隊(duì)成員：
張新潮，博士，助理研究員
張悅，研究生
課題組長(zhǎng)期招聘研究生和博士后等，歡迎咨詢！
