基本信息 >>>
研究方向>>>
醫(yī)學(xué)遺傳學(xué)和發(fā)育生物學(xué),，尤其是干細胞和哺乳動物胚胎工程等交叉領(lǐng)域的研究,。 |
個人簡歷 >>>
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曾凡一，美國賓夕法尼亞大學(xué)醫(yī)學(xué)/理學(xué)雙博士,，研究員,，博導(dǎo)。現(xiàn)任上海交通大學(xué)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院,，組織胚胎學(xué)與遺傳發(fā)育學(xué)系PI,，上海交通大學(xué)特聘教授、醫(yī)學(xué)院特聘教授,。 曾凡一教授主要從事醫(yī)學(xué)遺傳學(xué)和發(fā)育生物學(xué),，尤其是干細胞和哺乳動物胚胎工程等交叉領(lǐng)域的研究，在國際著名期刊《Nature》,、《PNAS》等雜志發(fā)表SCI論文90 余篇,，研究成果多次入選“中國基礎(chǔ)研究十大新聞”以及“中國十大科技進展新聞”。近年來獲得國家自然科學(xué)獎二等獎,、教育部自然科學(xué)獎一等獎,、首屆第三世界女青年科學(xué)家獎、談家楨生命科學(xué)獎創(chuàng)新獎等獎項,。擔(dān)任國際干細胞組織（ISCF）秘書長及倫理委員會中國代表,、中國遺傳學(xué)會第十屆理事會常務(wù)理事以及人類與醫(yī)學(xué)遺傳專業(yè)委員會主任委員等職務(wù)。 |
科研項目 >>>
2019YFA0801402 國家重點研發(fā)計劃子課題“胚層形成過程細胞分子調(diào)控機制”2019-12~2024-11 383.5萬 課題負責(zé)人 31871484 克隆牛重編程的表觀遺傳機理研究 國家自然科學(xué)基金(面上項目) 2019-01~2022-12 59萬元 課題負責(zé)人 17-163-12-ZT-005-051-01 新發(fā)病原體感染胚胎嵌合體修飾技術(shù) 國防科技創(chuàng)新特區(qū)課題 2017-07~2020-06 346萬元 課題負責(zé)人 2016YFC1000503 出生缺陷表觀遺傳異常模式及防控靶點 國家重點研發(fā)計劃“生殖健康及重大出生缺陷防控研究”重點專項 2016-07~2021-07 150萬元 課題參與人 2014CB964700 多能干細胞向中胚層細胞分化的機制研究 973計劃 2014-01~2018-08 910萬元 課題負責(zé)人 31371486 克隆牛重編程中核質(zhì)互作分子機理的探討 國家自然科學(xué)基金(面上項目) 2014-01~2017-12 80萬元 課題負責(zé)人 12XD1406500 遺傳病的個體化基因治療研究 上海市科學(xué)技術(shù)委員會優(yōu)秀學(xué)術(shù)帶頭人 2012-07~2014-06 20萬元 課題負責(zé)人 81125003 重編程技術(shù)在遺傳病個體化基因治療領(lǐng)域的應(yīng)用研究 國家杰出青年科學(xué)基金 2012-01~2015-12 240萬元 課題負責(zé)人 10GG10 幾種常見出生缺陷（先心,、神經(jīng)管缺陷）的分子機理研究 上海市教委曙光跟蹤項目 2011-01~2013-12 25萬元 課題負責(zé)人 / 重大遺傳性疾病的診斷,、治療和干預(yù)的新技術(shù)研究 衛(wèi)生部國家臨床重點專科建設(shè)項目 2011-01~2015-12 500萬元 課題負責(zé)人 2011AA020116 安全高效iPS誘導(dǎo)體系的建立 863計劃 2011-01~2015-12 157.9萬元 課題參與人 / 干細胞體內(nèi)組織模型對藥物性肝損傷修復(fù)的系統(tǒng)生物學(xué)研究 上海交通大學(xué)“理工交叉研究基金”重點項目 2011-01~2012-12 25萬元 課題負責(zé)人 10140900200 應(yīng)用囊胚注射技術(shù)制備并研究β654地貧小鼠轉(zhuǎn)基因干細胞嵌合體動物模型 上海市科委實驗動物研究項目 2010-05~2012-09 15萬元 課題負責(zé)人 30871379 表觀遺傳修飾對不同線粒體DNA單倍型來源胚胎發(fā)育的機理研究 國家自然科學(xué)基金(面上項目) 2009-01~2011-12 29萬元 課題負責(zé)人 08dj1400502 iPS細胞誘導(dǎo)的新方法和新材料 上海市科學(xué)技術(shù)委員會 2008-09~2011-09 50萬元 課題參與人 30770242 線粒體DNA單倍型及表觀遺傳對?？寺∨甙l(fā)育影響的機理 國家自然基金委(面上項目) 2008-01~2010-12 30萬元 課題負責(zé)人 2006BAI05A08 重大遺傳病產(chǎn)前篩查,、診斷技術(shù)規(guī)范化研究 國家十一五支撐計劃 2008-01~2010-12 42萬元 課題參與人 2007CB947800 干細胞表面分子特征與功能 國家科技部重大科學(xué)研究計劃 2007-07~2011-08 744.17萬元 課題負責(zé)人 06SG16 應(yīng)用MLPA-微陣列芯片技術(shù)對常見遺傳病進行基因診斷 上海市教育曙光計劃 2007-01~2009-12 12萬元 課題負責(zé)人 |
論文與專著 >>>
| Shuo Tan, Yuan Chen, Yue Gao, Jiaping He, Xinbing Guo, Simin Zhang, Jingzhi Zhang, Fanyi Zeng（通訊作者） |
β-Galactosidase gene codon optimization results in post-transcriptional enhancement of expression. |
Gene |
2020 |
748: 144676 |
| Yudan Fang, Yan Cheng, Dan Lu, Xiuli Gong, Guanheng Yang, Zhijuan Gong, Yiwen Zhu, Xiao Sang, Shuyue Fan, Jingzhi Zhang, Fanyi Zeng（通訊作者） |
Treatment of β654-thalassaemia by TALENs in a mouse model. |
Cell Proliferation |
2018 |
51(6): e12491 |
| Zhijuan Gong, Qingwen Ma, Xujun Wang, Qin Cai, Xiuli Gong, Georgi Z. Genchev, Hui Lu and Fanyi Zeng（通訊作者） |
A Herpes Simplex Virus Thymidine Kinase-Induced Mouse Model of Hepatocellular Carcinoma Associated with Up-Regulated Immune-Inflammatory-Related Signals. |
Genes |
2018
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9(8): 380, 2018 |
| Jingzhi Zhang, Jingbin Yan, Fanyi Zeng（通訊作者） |
Recent Progress on Genetic Diagnosis and Therapy for β-Thalassemia in China and Around the World. |
Human Gene Therapy |
2018 |
29(2): 197-203 |
| Chuanliang Guo, Yan Xue, Guanheng Yang, Shang Yin, Wansheng Shi, Yan Cheng, Xiaoshuang Yan, Shuyue Fan, Huijun Zhang, |
Nanog RNA binding proteins YBX1 and ILF3 affect pluripotency of embryonic stem cells |
Cell Biology International |
2016 |
40(8): 847-860 |
| Guanheng Yang, Wansheng Shi, Xingyin Hu, Jingzhi Zhang, Zhijuan Gong, Xinbing Guo, Zhaorui Ren, |
Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia |
Haematologica |
2014 |
99(8):1304-1311 |
| Xuesong Chen, Qi Gu, Xiang Wang, Qingwen Ma, Huixiang Tang, Xiaoshuang Yan, Xinbing Guo, Hao Yan, Jie Hao, |
Directed neuronal differentiation of mouse embryonic and induced pluripotent stem cells and their gene expression profiles |
Int J Mol Med |
2013 |
32(1):25-34 |
| Chenmin Yang, Chuanliang Gong, Jin Qiu, Huixiang Tang, Zhijuan Gong, Shuzhen Huang, |
Engraftment of genetically modified human amniotic fluid-derived progenitor cells to produce coagulation factor IX after in utero transplantation in mice |
Cell Biol Int |
2013 |
37(5):420-429 |
| , Shu-Zhen Huang, Zhi-Juan Gong, Mei-Jue Chen, Don A Baldwin, Wei Hu, Hui Qian, Jing-bin Yan, Juan Wang, Yan Ping Xiao, Yves Chalandon, Ashley Ringrose, Zhao-Rui Ren, Allen Eaves, Connie Eaves and Xiaoyan Jiang# |
Long-term deregulated human hematopoiesis in goats transplanted in utero with BCR-ABL-transduced lin?CD34+ cord blood cells |
Cell Res |
2013 |
23:859-862 |
| |
Studying Stem Cell Biology Using In Utero Transplantation in Animal Models |
Regenerative Medicine in China |
2012 |
14-15 |
| Fei Xie, Qingwen Ma, Shizhong Jiang, Zhaorui Ren, Juan Wang, Shuzhen Huang,, Yitao Zeng |
Adjusting the attB Site in Donor Plasmid Improves the Efficiency of ΦC31 Integrase System |
DNA and Cell Biology |
2012 |
31(7): 1335-1340 |
| Z.-J. Gong, Y.-Y. Zhou, M. Xu, Q. Cai, H. Li, J.-B. Yan, J. Wang, H.-J. Zhang, S.-Y. Fan, Q. Yuan, S.-Z. Huang, |
Aberrant expression of imprinted genes and their regulatory network in cloned cattle |
Theriogenology |
2012 |
78: 858-866 |
| Xiang Wang, Xuesong Chen, Huijun Zhang, Wenyi Qin, Yan Xue, |
Shared Gene Regulation during Human Somatic Cell Reprogramming |
J Genet Genomics |
2012 |
39(12):613-623 |
| Linlin Wang, Yan Xue, Yihang Shen, Wei Li, Yan Cheng, Xiaoshuang Yan, Wansheng Shi, Juan Wang, Zhijuan Gong, Guanheng Yang, Chuanliang Guo, Yiye Zhou, Xiang Wang, Qi Zhou, |
Claudin 6: a novel surface marker for characterizing mouse pluripotent stem cell |
Cell Res |
2012 |
22: 1082-1085 |
| Shu-Yang Xie, Wei Li, Zhao-Rui Ren, Shu-Zhen Huang,, Yi-Tao Zeng |
Correction of β654-thalassaemia mice using direct intravenous injection of siRNA and antisense RNA vectors |
Int J Hematol |
2011 |
93(3): 301-310 |
| Xiao-yang Zhao, Wei Li, Zhuo Lv, Lei Liu, Man Tong, Tang Hai, Jie Hao, Chang-long Guo, Xiang Wang, Liu Wang,, Qi Zhou |
Efficient and rapid generation of induced pluripotent stem cells using an alternative culture medium |
Cell research |
2010 |
20(3):383-386 |
| Xiao-yang Zhao, Wei Li, Zhuo Lv, Lei Liu, Man Tong, Tang Hai, Jie Hao, Xiang Wang, Liu Wang,, Qi Zhou |
Viable Fertile Mice Generated from Fully Pluripotent iPS Cells Derived from Adult Somatic Cells |
Stem Cell Rev and Rep |
2010 |
6: 390-397 |
| Yan Z, Zhou Y, Fu J, Jia F, Zhao L, Guan P, Huang S, Zeng Y, |
Donor-host mitochondrial compatibility improves efficiency of bovine somatic cell nuclear transfer |
BMC Dev Biol |
2010 |
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| Jing-bin Yan, Hong-ping Xu, Can Xiong, Zhao-rui Ren, Guo-li Tian,, Shu-zhen Huang |
Rapid and Reliable Detection of Glucose-6-Phosphate Dehydrogenase (G6PD) Gene Mutations in Han Chinese Using High-Resolution Melting Analysis |
Journal of Molecular Diagnostics |
2010 |
12(3): 305-311 |
| Zhao XY, Li W, Lv Z,, Zhou Q |
Production of mice using iPS cells and tetraploid complementation |
Nat Protoc |
2010 |
5(5): 963-971 |
| Jai-Yoon Sul, Chia-wen K. Wu,, Jeanine Jochems, Miler T. Lee, Tae Kyung Kim, Tiina Peritz, Peter Buckley, David J. Cappelleri, Margaret Maronski, Minsun Kim, Vijay Kumar, David Meaney, Junhyong Kim1, and James Eberwine1 |
Tranome transfer produces a predictable cellular phenotype |
PNAS |
2009 |
106(18):7624-7629. |
| Chen X, Gong XL, M. Katsumata, Zeng YT, Huang SZ, |
Hematopoietic stem cell engraftment by early-stage in utero transplantation in a mouse model |
Exp Mol Pathol |
2009 |
87(3): 173-177 |
| Xiao-yang Zhao, Wei Li, Zhuo Lv, Lei Liu, Man Tong, Tang Hai, Jie Hao, Chang-long Guo, Qing-wen Ma, Liu Wang,, Qi Zhou |
iPS cells produce viable mice through tetraploid complementationnear |
Nature |
2009 |
461(7260):86-90 |
| Lei-Wen Zhao,Xiao-Yu Yang,Peng-Fei Guan,Jing Fu,Hua Li, Yi-Ye Zhou,Shu-Zhen Huang,Yi-Tao Zeng, |
Improved efficiency of bovine somatic cell nuclear transfer by optimizing operational procedures |
Journal of reproduction and development |
2009 |
55(5):542-546 |
| Wei Li, Shuyang Xie, Xinbing Guo, Xiuli Gong, Shu Wang, Dan Lin, Jingzhi Zhang, Zhaorui Ren, Shuzhen Huang,, Yitao Zeng |
A novel transgenic mouse model produced from lentiviral germline integration for the study of beta-thalassemia gene therapy |
Haematologica |
2008 |
933:356-362 |
| Shuyang Xie, Wei Li, Zhaorui Ren, Jingzhi Zhang, Xinbin Guo, Shu Wang, Shuzhen Huang,, Yi-Tao Zeng |
Amelioration of beta(654)-thalassemia in mouse model with the knockdown of aberrantly spliced beta-globin mRNA |
J. Genet. Genomics, |
2008 |
35(10):595-601. |
| Jing Fu, Pengfei Guan, Leiwen Zhao, Hua Li, Shuzhen Huang,, Yitao Zeng |
Effects of donor cells on in vitro development of cloned bovine embryos |
Journal of Genetics and Genomics |
2008 |
35(5):273-278 |
| , Zhao-Rui Ren, Shang-Zhi Huang, Margot Kalf, Monique Mommersteeg, Maarten Smit, Stefan White, Chun-Lian Jin, Miao Xu, Da-Wen Zhou, Jing-Bin Yan, Mei-Jue Chen, Rinie van Beuningen, Shu-Zhen Huang, Johan den Dunnen, Yi-Tao Zeng, Ying Wu |
Array-MLPA: Comprehensive Detection of Deletions and Duplications and Its Application to DMD Patients |
Human Mutation |
2008 |
29(1):190-197. |
| FEI JIAO, JING-BIN YAN, XIAO-YU YANG, HUA LI, QINGXUE WANG, SHU-ZHEN HUANG,, YI-TAO ZENG |
Effect of Oocyte Mitochondrial DNA Haplotype on Bovine Somatic Cell Nuclear Transfer Efficiency |
Molecular Reproduction and Development |
2007 |
74(10):1278-1286 |
| Chia-wen K.Wu,, James Eberwine |
mRNA transport to and translation in neuronal dendrites |
Anal Bioanal Chem |
2007 |
387:59-62. |
| Chunli Zhao, Ruqiang Yao, Jie Hao, Chenhui Ding, Yong Fan, Xiangpeng Dai, Wei Li, Tang Hui, Zichuan Li, Yang Yu, Yingying Wang, Xiaojun Hou, Wei zhi Ji, Qi Zhou, Alice Jouneau,, Lin Wang |
Establishment of customized mouse stem cell lines by sequential nuclear transfer |
Cell Research |
2007 |
17(1):80-87 |
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專利與技術(shù)許可 >>>
一種建立人/山羊造血干細胞異種移植模型的方法 ZL 0113 2 231.4 一種多能干細胞表面標志物及其用途 ZL 2012 1 0082520.2 一種小鼠宮內(nèi)干細胞移植工具 ZL 2008 2 0154065.1 一種細胞核移植方法 ZL 2006 1 0029674.X |
榮譽與獎勵 >>>
國家自然科學(xué)獎二等獎 首屆婦幼健康科學(xué)技術(shù)獎自然科學(xué)獎一等獎 教育部自然科學(xué)獎一等獎 教育部自然科學(xué)獎二等獎 上海市科技進步獎二等獎 上海醫(yī)學(xué)科技獎一等獎 上海醫(yī)學(xué)科技獎二等獎 首屆第三世界婦女科學(xué)組織女青年科學(xué)家獎 第六屆中國青年女科學(xué)家獎 第十屆中國青年科技獎 第五屆談家楨生命科學(xué)獎創(chuàng)新獎 教育部新世紀優(yōu)秀人才支持計劃 上海市“曙光學(xué)者” 上海市“浦江人才” 上海市領(lǐng)軍人才 上海市優(yōu)秀學(xué)術(shù)帶頭人 上海市衛(wèi)生系統(tǒng)第十一屆銀蛇獎 上?？破战逃齽?chuàng)新獎科普貢獻獎（個人）一等獎 上海市第一屆醫(yī)樹獎醫(yī)學(xué)科普創(chuàng)新獎 全國巾幗建功標兵 第六屆上海市巾幗創(chuàng)新獎 上海市統(tǒng)一戰(zhàn)線（工作）先進個人 中國僑界（創(chuàng)新成果）貢獻獎 |
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