国产成人嫩模一区二区|超级黄色网页|兔子先生tz|麻豆文化传媒网站官网污|在线播放欧美日韩精品|爱豆影视传媒免费下载|蜜桃影像传媒av剧情|麻豆文化传媒APP最新iOS|陈可心倩女幽魂爱豆传媒|91国视频产,国产传媒播放,想看三级片,网红吃瓜黑料爆料网反差

 
師資隊(duì)伍
郭曉奎
  作者:  2018-12-31
基本信息 >>>

 郭曉奎
  免疫學(xué)與微生物學(xué)系
  電話:63846590-776712
  郵箱:[email protected]

研究方向>>>

   耐藥細(xì)菌控制技術(shù),、鉤短螺旋體分子生物學(xué)及人體微生態(tài)學(xué)與益生菌安全性研究,。

個(gè)人簡(jiǎn)歷 >>>

    郭曉奎,教授,,博士生導(dǎo)師,。1986年8月參加工作,1986年7月加入中國(guó)共產(chǎn)黨,。

        1986年畢業(yè)于四川大學(xué),,1991年于哈爾濱醫(yī)科大學(xué)獲碩士學(xué)位,2000年于日本愛(ài)知學(xué)院大學(xué)獲生物化學(xué)博士學(xué)位?,F(xiàn)為國(guó)家級(jí)教學(xué)名師,,全國(guó)教育科研先進(jìn)工作者,全國(guó)優(yōu)秀教師,,上海市優(yōu)秀學(xué)科帶頭人,。

        現(xiàn)任:上海交通大學(xué)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院副院長(zhǎng),上海交通大學(xué)醫(yī)學(xué)科學(xué)研究院“醫(yī)學(xué)分子微生物學(xué)”研究組課題組長(zhǎng),。

        兼任:中華預(yù)防醫(yī)學(xué)會(huì)微生態(tài)學(xué)分會(huì)副主任委員,,中國(guó)微生物學(xué)會(huì)教育與普及工作委員會(huì)副主任委員,上海市微生物學(xué)會(huì)副理事長(zhǎng)以及食品微生物學(xué)專委會(huì)主任委員,,上海市預(yù)防醫(yī)學(xué)會(huì)理事以及微生態(tài)學(xué)專委會(huì)主任委員,,上海市食品科學(xué)學(xué)會(huì)理事及乳酸菌專委會(huì)副主任委員,《中國(guó)人獸共患病學(xué)報(bào)》副主編,。

        長(zhǎng)期從事醫(yī)學(xué)分子微生物學(xué)和病原基因組學(xué)研究,,主要內(nèi)容有鉤端螺旋體和分枝桿菌基因組學(xué)和蛋白質(zhì)組學(xué)及其致病機(jī)制和疫苗的研究,耐藥細(xì)菌控制技術(shù),,人體呼吸道感染微生態(tài)學(xué)與益生菌等,。

科研項(xiàng)目 >>>

8126116032 鉤端螺旋體與宿主細(xì)胞相互作用及其分子致病機(jī)制的研究 國(guó)家自然科學(xué)基金 2013-01~2015-12  52萬(wàn)元   子課題負(fù)責(zé)人

81271793 不同動(dòng)物源性致病性鉤端螺旋體遺傳變異規(guī)律和致病差異的分子機(jī)制研究 國(guó)家自然科學(xué)基金 2013-01~2016-12  60萬(wàn)元   課題負(fù)責(zé)人

2012EP001004 超級(jí)細(xì)菌的預(yù)警監(jiān)控和臨床防治綜合評(píng)價(jià)信息化平臺(tái)的建立 科技部支撐計(jì)劃 2012-01~2015-12  75萬(wàn)元   子課題負(fù)責(zé)人

81171587 基于Pan-genome技術(shù)探究問(wèn)號(hào)鉤端螺旋體不同血清型致病性差異的遺傳基礎(chǔ) 國(guó)家自然科學(xué)基金 2012-01~2015-12  58萬(wàn)元   課題負(fù)責(zé)人

2011AA02A100 自動(dòng)化臨床微生物分析檢測(cè)儀器的研制 863重大專項(xiàng) 2011-09~2015-12  300萬(wàn)元   課題負(fù)責(zé)人

10JC1408200 重要人獸共患病鉤端螺旋體病通用疫苗的基礎(chǔ)研究 上海市科委 2010-10~2012-09  30萬(wàn)元   課題負(fù)責(zé)人

09XD1402700 鉤端螺旋體rel基因致病機(jī)理的研究 上海市科委 2009-07~2011-06  40萬(wàn)元   課題負(fù)責(zé)人

2008ZX10004-002 呼吸道感染和感染性腹瀉病原體診斷和組合檢測(cè)技術(shù) “十一五”重大專項(xiàng)子課題 2008-01~2010-12  300萬(wàn)元   子課題負(fù)責(zé)人

30770111 鉤端螺旋體比較蛋白質(zhì)組學(xué)研究 國(guó)家自然科學(xué)基金 2008-01~2010-12  30萬(wàn)元   課題負(fù)責(zé)人

30670102 鉤體血清型相關(guān)基因的研究 國(guó)家自然科學(xué)基金 2007-01~2009-12  26萬(wàn)元   課題負(fù)責(zé)人

2006AA02Z176 鉤端螺旋體重要功能基因的發(fā)掘、鑒定和應(yīng)用 國(guó)家科技部 “863”計(jì)劃 2006-01~2008-12  330萬(wàn)元   課題負(fù)責(zé)人

2003AA223030 鉤端螺旋體致病及免疫機(jī)理的功能基因組學(xué)研究 國(guó)家科技部 “863”計(jì)劃 2004-01~2005-12  157.3萬(wàn)元   課題負(fù)責(zé)人

30370071 鉤端螺旋體溶血素基因結(jié)構(gòu),、表達(dá)及功能的研究 國(guó)家自然科學(xué)基金 2004-01~2006-12  20萬(wàn)元   課題負(fù)責(zé)人

2001AA223030 鉤端螺旋體致病及免疫機(jī)理的功能基因組學(xué)研究 國(guó)家科技部 “863”計(jì)劃 2001-01~2003-12  141.1萬(wàn)元   課題負(fù)責(zé)人

論文與專著 >>>

Yinghua Xu, Yongzhang Zhu,Yuezhu Wang, Yung-Fu Chang, Ying Zhang, Xiugao Jiang, Xuran Zhuang, Yongqiang Zhu, Jinlong Zhang, Lingbing Zeng, Minjun Yang, Shijun Li, Shengyue Wang, Qiang Ye, Xiaofang Xin, Guoping Zhao, Huajun Zheng, Xiaokui Guo* (通訊作者), Junzhi Wang*   Whole genome sequencing revealed virulence-relatedproteins expansion and host adaptation of pathogenic Leptospira   Scitific Reports   2016   6:20020   

Zhu W, Wang J, Zhu Y, Tang B, Zhang Y, He P, Zhang Y, Liu B, Guo X* (通訊作者), Zhao G*, Qin J*   Identification of three extra-chromosomal replicons in Leptospira pathogenic strain and development of new shuttle vectors   BMC Genomics   2015   16:90   

Yanzhuo Wang, Xuran Zhuang, Yi Zhong, Cuicai Zhang, Yan Zhang, Lingbing Zeng, Yongzhang Zhu, Ping He, Dong Ke, Utpal Pal, Xiaokui Guo* (通訊作者), Jinhong Qin*   Distribution of Plasmids in Distinct Leptospira Pathogenic Species   PLoS Negl Trop Dis   2015   9(11):e0004220   

Zhang C, Yang H, Li X, Cao Z, Zhou H, Zeng L, Xu J, Xu Y, Chang YF, Guo X* (通訊作者), Zhu YZ*, Jiang X*. . . 2015; 9(5):e0003762.   Molecular Typing of Pathogenic Leptospira Serogroup Icterohaemorrhagiae Strains Circulating in China during the Past 50 Years   PLoS Negl Trop Dis   2015   9(5):e0003762   

Wei YX, Ye L, Liu DB, Zhang ZY, Liu C*, Guo XK* (通訊作者)   Activation of the chromosomally encoded mazEF(Bif) locus of Bifidobacterium longum under acid stress   Int J Food Microbiol   2015   207:16-22   

Zhao JW, Sun ZQ, Zhang XY, Zhang Y, Liu J, Ye J, Chen CC, Samten B, Wang HH, Guo XK* (通訊作者), Zhang SL*   Mycobacterial 3-hydroxyacyl-l-thioester dehydratase Y derived from Mycobacterium tuberculosis induces COX-2 expression in mouse macrophages through MAPK-NF-κB pathway   Immunol Lett   2014   161(1):125-132   

Ling-Bing Zeng, Xu-Ran Zhuang, Li-Li Huanga, Yun-Yi Zhang, Chun-Yan Che,Ke Dong, Yan Zhang, Ze-Lin Cui, Xia-Li Ding, Yung-Fu Chang, Xiao-Kui Guo* (通訊作者), Yong-Zhang Zhu*   Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants   J Proteomics   2014   112C:27-37   

Yuan L, Cui Z, Wang Y, Guo X* (通訊作者), Zhao Y*   Complete genome sequence of virulent bacteriophage SHOU24, which infects foodborne pathogenic Vibrio parahaemolyticus   Arch Virol   2014   159(11):3089-3093   

Jiyun Fan, Ying Wang, Hui Xiong, Xiaokui Guo* and Yung-chi Cheng* (通訊作者)   Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility   J Gen Virol   2014   95(Pt 11):2523-2530   

Wei-Nan Zhu, Li-Li Huang, Ling-Bing Zeng, Xu-Ran Zhuang, Chun-Yan Chen, Yan-Zhuo Wang, Jin-Hong Qin, Yong-Zhang Zhu*, Xiao-Kui Guo*... 2014;. (通訊作者)   Isolation and Characterization of Two Novel Plasmids from Pathogenic Leptospira interrogans Serogroup Canicola Serovar Canicola Strain Gui44   PLoS Negl Trop Dis   2014   8(8):e3103   

Zhang ZY, Sun ZQ, Wang ZL, Hu HR, Wen ZL, Song YZ, Zhao JW, Wang HH, Guo XK* (通訊作者),Zhang SL*   Identification and pathogenicity analysis of a novel non-tuberculous mycobacterium clinical isolate with nine-antibiotic resistance   Clin Microbiol Infect   2013   19:91-3   

Yaoxia Kang, Enhou Jia, Liang Lin, Xiangyang Duan, Pei Xiao, Jingxian Peng, Wei Gao, Chaobao Zhang, Xiaokui Guo* (通訊作者), Buyun Cui*, and Xiangqi Li*   Simultaneous emergence of several biotypes of Brucella among Baotou’s brucellosis patients by combined diagnostic strategy   Acta Biochim Biophys Sin (Shanghai)   2013   45: 893–895    

Zhang Y, Dong K, Zeng L, Li Q, Liu C, Wang J, Guo X* (通訊作者), Zhao GP*   .Genetic and molecular biological characterization of two homologous cheR genes from Leptospira interrogans   Acta Biochim Biophys Sin (Shanghai)   2013   45(10):806-816   

Zelin Cui, Yuhua Zhou, Hong Li, Yan Zhang, Shenjie Tang, Xiaokui Guo* (通訊作者)   Complex sputum microbial composition in patients with pulmonary tuberculosis   BMC microbiology   2012   12:276   

Zelin Cui, Zhen Song, Yanchun Wang, LingbingZeng, WenbinShen, Zheng Wang, Qingtian Li, Ping He, Jinhong Qin*, and Xiao-Kui Guo* (通訊作者)   Complete Genome Sequence of wide host-range Staphylococcus aureus phage JD007   Journal of Virology   2012   86(24):13880   

Zhou Y, Tao J, Yu H, Ni JJ, Zeng LB, Teng QH, Kim K, Zhao GP, Guo XK* (通訊作者), and Yao YF*   Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells   Infection and Immunity   2012   80(3):1243-51   

Zhang ZY, Liu C, Zhu YZ, Wei YX, Tian F, Zhao GP, Guo XK* (通訊作者)   Safety assessment of Lactobacillus plantarumJDM1 based on the complete genome   Int J Food Microbiol   2012   153(1-2):166-70   

Zelin Cui, WenbinShen, Zheng Wang, Haotian Zhang, Rao Me, Yanchun Wang, LingbingZeng, Yongzhang Zhu, Jinhong Qin, Ping He*, and Xiao-Kui Guo* (通訊作者)   Complete Genome Sequence of Klebsiellapneumoniae phage JD001   Journal of Virology   2012   86(24):13843   

Wei YX, Zhang ZY, Liu C, Malakar PK, Guo XK* (通訊作者)   Safety assessment of Bifidobacterium longum JDM301 based on complete genome sequences   World J Gastroenterol   2012   18(5):479-88   

Zhong Y, Chang X, Cao XJ, Zhang Y, Zheng H, Zhu Y, Cai C, Cui Z, Zhang Y, Li YY, Jiang XG, Zhao GP, Wang S, Li Y, Zeng R, Li X, Guo XK (通訊作者)   Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601   Cell Research   2011   21(8):1210-1229   

Zhang ZY, Sun ZQ, Wang ZL, Wen ZL, Sun QW, Zhu ZQ, Song YZ, Zhao JW, Wang HH, Zhang SL, Guo XK (通訊作者)   Complete genome of a novel clinical isolated non-tuberculous mycobacterium strain JDM601.. 2011, 193 (16): 4300-1   J Bacteriol   2011   193 (16):4300-4301   

Zhang SM, Tian F, Huang QF, Zhao YF, Guo XK (通訊作者), Zhang FQ   Bacterial diversity of subgingival plaque in 6 healthy Chinese individuals   Exp Ther Med   2011   2(5):1023-1029   

Li QT, Zhou YH, Dong K, Guo XK. (通訊作者)   Potential therapeutic efficacy of a bactericidal-immunomodulatory fusion peptide against methicillin-resistant Staphylococcus aureus skin infection.    Appl Microbiol Biotechnol.   2010   86(1):305-9   

Yan-Xia Wei, Zhuo-Yang Zhang, Chang Liu,Yong-Zhang Zhu, Yong-Qiang Zhu, Hua-Jun Zheng, Guo-Ping Zhao, Sheng-Yue Wang, and Xiao-Kui Guo (通訊作者)   Complete Genome Sequence of Bifidobacterium longum JDM301.    J. Bacteriol   2010   192(15):4076-4077   

Liu C, Zhang ZY, Dong K, Guo XK (通訊作者)   Adhesion and immunomodulatory properties of Bifidobacterium lactis HN019 to intestinal epithelial cells INT-407.    World Journal of Gastroenterology   2010   16 (18):2283-2290   

Dong K, Li QT, Liu C, Zhang YY, Zhao GP, Guo XK. (通訊作者)   Cloning and characterization of three cheB genes in Leptospira interrogans    Acta Biochim Biophys Sin (Shanghai)   2010   42 (3):216-223   

Yuhua Zhou, Qingtian Li, Lizhong Han, Ping Lin, Huajun Zheng, Yanxia Wei, Zelin Cui, Yuxing Ni, Xiaokui Guo (通訊作者)   The microbiota analyses of sputum from the patients of lower respiratory tract infection using 16S rDNA pyro-sequencing. 42 :754-761   Acta Biochim Biophys Sin   2010   42:754-761   

Zhu YZ, Cai CS, Zhang W, Guo HX, Zhang JP, Ma GY, Ji YY, Wu JL, Li QT, Lu CP, Guo XK (通訊作者)   Immunoproteomic Analysis of Human Serological Antibody Responses to Vaccination with Whole-Cell Pertussis Vaccine (WCV)   PLoS ONE   2010   5(11):13915-13915   

Cai CS, Zhu YZ, Zhong Y, Xin XF, Jiang XG, Lou XL, He P, Qin JH, Zhao GP, Wang SY, Guo XK (通訊作者)   Development of O-antigen gene cluster-specific PCRs for rapid typing six epidemic serogroups of Leptospira in China.    BMC microbiology   2010   10(67):1230-1236   

Yuan JP, Li P, Tao J, Shi XD, Hu BY, Chen HB, Guo XK (通訊作者)   H.pylori Escape Host Immunoreaction Through Inhibiting ILK Expression By VacA.    Cellular & Molecular Immunology   2009   6(3):91-97   

Zhao W, Chen CY, Zhang XY, Lai WQ, Hu BY, Zhao GP, Qin JH, Guo XK (通訊作者)   Molecular characterization of the pL40 protein in Leptospira interrogans    Can. J. Microbiol   2009   55 (6):739-749   

Zhang SM, Tian F, Jiang XQ, Li J, Xu C,Guo XK (通訊作者), Zhang FQ.    Evidence for calcifying nanoparticles in gingival crevicular fluid and dental calculus in periodontitis.   Journal of Periodontology   2009   80 (9):1462-1470   

Tian F, Yu Y, Chen B, Li HR, Yao YF, Guo XK (通訊作者)   Bacterial, archaeal and eukaryotic diversity in Arctic sediment as revealed by 16S rRNA and 18S rRNA gene clone libraries analysis.    Polar Biology   2009   32 (1):93-103   

Zhang ZY, Liu C, Zhu YZ, Zhong Y, Zhu YQ, Zheng HJ, Zhao GP, Wang SY, Guo XK (通訊作者)   Complete genome sequence of Lactobacillus plantarum JDM1.   J. Bacteriol.   2009   191(15):5020-5021   

Liu C, Zhang ZY, Dong K, Yuan JP,Guo XK (通訊作者)   Antibiotic resistance of probiotic strains of lactic acid bacteria isolated from marketing food and drugs.   Biomedical and Enviromental Science   2009   22(5):401-412   

Feng CY, Li QT, Zhang XY, Dong K, Hu BY, Guo XK (通訊作者)   Immune strategies on single component LipL32 and multi-components recombinant LipL32-41-OmpL1 vaccines against Leptospira.    Brazilian Journal of Medical and Biological Research   2009   42(9):796-803   

He P, Sheng YY, Shi YZ, Jiang XG, Qin JH, Zhang ZM, Zhang GP, Guo XK (通訊作者)   Genetic diversity among major endemic strains of Leptospira interrogans in China   BMC Genomics   2008   8(14):204-7   

Qin JH, Zhang Q, Zhang ZM, Zhong Y, Yang Y, Hu BY, Zhao GP, Guo XK (通訊作者)   Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar lai.   Infect Immun   2008   76(6):2411-9   

Zhu YZ, Li QT, Wang L, Zhong Y, Ding GH, Li G, Jia PL, Shi TL, Guo XK (通訊作者)   Gene Expression Profiling-Based In Silico Approach to Identify Potential Vaccine Candidates and Drug Targets against B. pertussis and B. parapertussis.   OMICS   2008   12 (3):161-169   

Guo XK (共同第一作者), Zhao WQ, Kondo C, Shimojo N, Yamashita K, Aoki T, Hayakawa T   Tissue inhibitors of metalloproteinases-1 (TIMP-1) and-2(TIMP-2) are major serum factors that stimulate the TIMP-1 gene in human gingival fibroblasts.    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH   2007   1763(3):296-304   

Li ZH, Dong K, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK (通訊作者)   Characterization of the cheY genes from Leptospira interrogans and their effects on the behavior of Escherichia coli.    Biochem Biophys Res Commun   2006   345(2):858-866   

Li QT, Zhu YZ, Chu JY, Wang YY, Xu YH, Hou QM, Zhang SM, Guo XK (通訊作者)   Protective immunity against Bordetella pertussis by a recombinant DNA vaccine and the effect of coinjection with a granulocyte-macrophage colony stimulating factor gene.    Microbiol Immunol   2006   50(12):929-36.   

Sun JC, Xu JL, Cao JP, Liu Q, Guo XK (通訊作者), Shi TL   Prediction and systematic study of protein-protein interaction networks of Leptospira interrogans.   Chinese science Bulletin   2006   51(1):1-10   

Li QT, Zhu YZ, Chu JY, Dong K, He P, Feng CY, Hu BY, Zhang SM, Guo XK (通訊作者)   Granulocyte-macrophage Colony-stimulating Factor DNA Prime-protein Boost Strategy to Enhance the Efficacy of a Recombinant Pertussis DNA Vaccine    Acta Pharmacologica Sinica   2006   27 (11):1487-1494   

Li ZH, Dong K, Sun JC, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK (通訊作者)   Characterization of cheW Genes of Leptospira interrogans and Their Effects in Escherichia coli.    Acta Biochim Biophys Sin   2006   38(2):79-88   

Yang HL, Jiang XC, Zhang XY, Li WJ, Hu BY, Zhao GP, Guo XK (通訊作者)   Thrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation.    BMC Infect Dis   2006   6(1):19-25   

Yang HL, Zhu YZ, Qin JH, He P, Jiang XC, Zhao GP, Guo XK (通訊作者)   In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans.    BMC Genomics   2006   16(7):239-240   

Qin JH, Sheng YY, Zhang ZM, Shi XZ, He P, Hu BY, Yang Y, Liu SG, Zhao GP, Guo XK (通訊作者)   Genome-wide tranional analysis of temperature shift in L. interrogans serovar lai strain 56601   BMC Microbiology   2006   6(51):1-10   

專利與技術(shù)許可 >>>

 

 

教學(xué)工作 >>>

 

 

榮譽(yù)與獎(jiǎng)勵(lì) >>>