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師資隊伍
李福彬
  作者:  2018-12-31
基本信息 >>>    

 李福彬
  免疫學與微生物學系
  電話:63846590-776624
  郵箱:[email protected]

研究方向>>>

    Fcγ受體在免疫應(yīng)答和免疫治療中的功能和分子作用機制,,如對B細胞應(yīng)答的調(diào)控及對包括激動型的各類抗體效應(yīng)的影響,。

個人簡歷 >>>

    李福彬研究員,博士生導(dǎo)師,,體液免疫與治療課題組課題組長;上海市教育基金會/上海市教育委員會“曙光學者”,。   

        1997-2001 復(fù)旦大學 學士

        2002-2008 美國紐約城市大學 博士

        2009-2013 美國洛克菲勒大學 博士后

        2013.09-至今上海交通大學醫(yī)學院上海市免疫學研究所課題組長 博士生導(dǎo)師

科研項目 >>>

1. 14SG16,,上海市教委科研創(chuàng)新重點項目,,曙光計劃2015-2017,,項目負責人

2. 2014CB943600,,科技部國家重點基礎(chǔ)研究發(fā)展計劃(973計劃) 淋巴細胞發(fā)育中的基金轉(zhuǎn)錄后調(diào)節(jié)網(wǎng)絡(luò)研究20144月至20188,,科研骨干

3. 15ZR1436400,,上海市科委自然科學基金面上項目Fc-huCD40L融合蛋白的抗腫瘤活性及其副作用的研究,,2015-2018,,張慧慧

4. 2015上海市教委,,科研創(chuàng)新重點項目,,上海高層次人才2015-2017,,張慧慧

6. 31422020,,國家自然科學基金優(yōu)青項目基于抗體Fc的分子靶向治療,,2015-2017,,項目負責人

7. 31370934國家自然科學基金面上項目,,抑制型Fcgamma受體驅(qū)動激動型抗TNFR超家族成員抗體抗腫瘤活性的機制,,2014-2017項目負責人

論文與專著 >>>

1.  Dahan, R., B. C. Barnhart, F. Li, A. P. Yamniuk, A. Korman, J.V. Ravetch. .Therapeutic activity of agonistic, human anti-CD40 monoclonal Abs requires ive FcγR-engagement. .Cancer Cell ,2016,29(6):820-831.  

2.  Georgoudaki, A.M., K. Prokopec, E. Hellqvist, V. Boura, J. ?stling, S. Sohn, R.A. Harris, M. Rantalainen, D. Klevebring, M. Sund, J. Fuxe, C. Rolny, F. Li, J.V. Ravetch, M.C.I. Karlsson. .Reprogramming tumor associated macrophages by antibody targeting inhibits cancer progression and metastasis. .Cell Reports ,2016,15(9):2000-11.  

3.  Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H. .Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses..Nature Immunology,2015,16:642-52.  

4.  Li, F#., P. Smith, and J. V. Ravetch#. .Inhibitory Fcgamma Receptor Is Required for the Maintenance of Tolerance through Distinct Mechanisms. .Journal of immunology ,2014,192:3021-8 .  

5.  Simpson, T. R., F. Li, W. Montalvo-Ortiz, M. A. Sepulveda, K. Bergerhoff, F. .Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.The Journal of experimental medicine,2013,210: 1695-1710.  

6.  Li, F#., and J. V. Ravetch#. .Antitumor activities of agonistic anti-TNFR antibodies require differential FcgammaRIIB coengagement in vivo. .Proceedings of the National Academy of Sciences of the United States of America,2013,110: 19501-19506. 

7.  Smith, P., D.J. Dilillo, S. Bournazos, F. Li, and J.V. Ravetch.Mouse model recapitulating human Fcgamma receptor structural and functional diversity. .Proceedings of the National Academy of Sciences of the United States of America ,2012,109:6181-6186. 

8.  Li, F., and J. V. Ravetch.Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcgamma receptor engagement..Proceedings of the National Academy of Sciences of the United States of America ,2012,109: 10966-10971. 

9.  Li, F., and J. V. Ravetch.A general requirement for FcgammaRIIB co-engagement of agonistic anti-TNFR antibodies..Cell cycle ,2012,11: 3343-3344. 

10.  Li, F., and J.V. Ravetch.Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. .Science ,2011,333:1030-1034. 

11.  Li, F., Y. Yan, J. Pieretti, D.A. Feldman, and L.A. Eckhardt. .Comparison of identical and functional Igh alleles reveals a nonessential role for Emu in somatic hypermutation and class-switch recombination. .Journal of immunology ,2010,185:6049-6057. 

12.  Li, F., and L.A. Eckhardt.A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.The Journal of experimental medicine ,2009,206:153-167. 

13.  Zhang, B., A. Alaie-Petrillo, M. Kon, F. Li, and L.A. Eckhardt.Tranion of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3 regulatory region. .Journal of immunology ,2007,178:6297-6306. 

14.  Romov, P.A., F. Li, P.N. Lipke, S.L. Epstein, and W.G. Qiu..Comparative genomics reveals long, evolutionarily conserved, low-complexity islands in yeast proteins. .Journal of molecular evolution,2006,63:415-425. 

15.  Garrett, F.E., A.V. Emelyanov, M.A. Sepulveda, P. Flanagan, S. Volpi, F. Li, D. Loukinov, L.A. Eckhardt, V.V. Lobanenkov, and B.K. Birshtein.Chromatin architecture near a potential 3 end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites.Molecular and cellular biology,2005,25:1511-1525. 

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