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師資隊(duì)伍
劉俊嶺
  作者:  2018-12-31

基本信息 >>>

 劉俊嶺
  生物化學(xué)與分子細(xì)胞生物學(xué)系
  電話:63846590-776345
  郵箱:[email protected]

研究方向>>>

1. 粘附受體介導(dǎo)的信號(hào)傳導(dǎo)在血小板激活中的作用,。

2. 動(dòng)脈粥樣硬化發(fā)生發(fā)展機(jī)制。

3. 基質(zhì)細(xì)胞在腫瘤轉(zhuǎn)移微環(huán)境形成中的作用研究,。

個(gè)人簡(jiǎn)歷 >>>

劉俊嶺研究員,,博士生導(dǎo)師。美國(guó)血液學(xué)會(huì)會(huì)員,,中華醫(yī)學(xué)會(huì)細(xì)胞生物專業(yè)青年委員,,教育部新世紀(jì)優(yōu)秀人才、上海市高層次人才,。

教育經(jīng)歷:

19936月畢業(yè)于新疆醫(yī)學(xué)院藥學(xué)本科專業(yè),;

1995-1998年在新疆醫(yī)學(xué)院天然藥物化學(xué)教研室攻讀碩士學(xué)位,師從堵年生教授,課題內(nèi)容為中草藥化學(xué)成分提取,、分離以及結(jié)構(gòu)鑒定,,獲得天然藥物化學(xué)碩士學(xué)位;

1998-2001年在北京大學(xué)醫(yī)學(xué)部藥學(xué)院藥物化學(xué)系攻讀博士學(xué)位,,師從彭師奇教授,,課題內(nèi)容為具有生物活性小分子化合物合成及其活性評(píng)價(jià)。

工作經(jīng)歷:

2001-2006年在美國(guó)孟菲斯大學(xué)微生物及細(xì)胞分子生物學(xué)系進(jìn)行博士后研究,,主要從事血小板粘附受體及其介導(dǎo)信號(hào)在血栓性疾病中的作用研究,;

2006-2008在美國(guó)伊利諾伊大學(xué)芝加哥分校醫(yī)學(xué)院藥理系任研究助理教授,從事血栓止血分子機(jī)制的研究,。2008回國(guó)在上海交通大學(xué)醫(yī)學(xué)院任研究員,,獲上海市浦江人才計(jì)劃支持。

科研項(xiàng)目 >>>

1. 國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目

項(xiàng)目編號(hào):82030004

項(xiàng)目名稱:糖代謝調(diào)控血小板生成和凋亡的作用機(jī)制研究

項(xiàng)目負(fù)責(zé)人:劉俊嶺

資助部門:國(guó)家自然科學(xué)基金委

起始年限:2021年1月至2025年12月

資助金額:297萬(wàn)

2. 國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目

項(xiàng)目編號(hào):31830050

項(xiàng)目名稱:代謝調(diào)控血小板衰老死亡的分子機(jī)制

項(xiàng)目負(fù)責(zé)人:劉俊嶺

資助部門:國(guó)家自然科學(xué)基金委

起始年限:2019年1月至2023年12月

資助金額:288萬(wàn)

3. 國(guó)家自然科學(xué)基金重大研究計(jì)劃集成項(xiàng)目

項(xiàng)目編號(hào):91739302

項(xiàng)目名稱:危重血管性疾病血栓事件的發(fā)生,、發(fā)展及干預(yù)研究

項(xiàng)目負(fù)責(zé)人:劉俊嶺

資助部門:國(guó)家自然科學(xué)基金委

起始年限:2018年1月至2020年12月

資助金額:210萬(wàn)

4. 國(guó)家自然科學(xué)基金國(guó)家杰出青年基金

項(xiàng)目編號(hào):81525001

項(xiàng)目名稱:血小板活化的分子調(diào)控機(jī)制研究

項(xiàng)目負(fù)責(zé)人:劉俊嶺

資助部門:國(guó)家自然科學(xué)基金委

起始年限:2016年1月至2020年12月

資助金額:350萬(wàn)

5. 國(guó)家自然科學(xué)基金重大研究計(jì)劃培育項(xiàng)目

項(xiàng)目編號(hào):91439115

項(xiàng)目名稱:血小板內(nèi)皮聚集受體1調(diào)控血管穩(wěn)態(tài)作用機(jī)制研究

項(xiàng)目負(fù)責(zé)人:劉俊嶺

資助部門:國(guó)家自然科學(xué)基金委

起始年限:2015年1月至2017年12月

資助金額:150萬(wàn)

6. 科技部973子課題

項(xiàng)目編號(hào):2012CB518001

項(xiàng)目名稱:GPCR介導(dǎo)的血管炎癥和損傷

項(xiàng)目負(fù)責(zé)人:劉俊嶺

資助部門:科技部

起始年限:2012年1月至2016年12月

資助金額:289萬(wàn)

7. 國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目

項(xiàng)目編號(hào):81030039

項(xiàng)目名稱:血小板介導(dǎo)預(yù)轉(zhuǎn)移微環(huán)境的形成及其在肺癌轉(zhuǎn)移中的作用

項(xiàng)目負(fù)責(zé)人:劉俊嶺

資助部門:國(guó)家自然科學(xué)基金委

起始年限:2011年1月至2014年12月

資助金額:200萬(wàn)

8. 國(guó)家自然科學(xué)基金面上項(xiàng)目

項(xiàng)目編號(hào):81170479

項(xiàng)目名稱:整合素αIIb亞基介導(dǎo)信號(hào)在血小板活化和血栓形成中的作用

項(xiàng)目負(fù)責(zé)人:劉俊嶺

資助部門:國(guó)家自然科學(xué)基金委BMCB 2011 56

起始年限:2012年1月至2015年12月

資助金額:60萬(wàn)

9. 上海市教委和教育發(fā)展基金會(huì)曙光學(xué)者

項(xiàng)目編號(hào):10SG21

項(xiàng)目名稱:血小板在肺癌預(yù)轉(zhuǎn)移微環(huán)境形成中的作用研究

項(xiàng)目負(fù)責(zé)人:劉俊嶺

資助部門:上海市科委

起始年限:2011年1月至2013年12月

資助金額:15萬(wàn)


論文與專著 >>>

1. Jiang H, Yu Z, Ding N, Yang M, Zhang L, Fan X, Zhou Y, Zou Q, Hou J, Zheng J, Zhang L, Xu Y, Liu J. The role of AGK in thrombocytopoiesis and possible therapeutic strategies.Blood. 2020 Jul 2;136(1):119-129. doi: 10.1182/blood.2019003851.Blood. 2020. PMID: 32202634

2. Xu Y, Jiang H, Li L, Chen F, Liu Y, Zhou M, Wang J, Jiang J, Li X, Fan X, Zhang L, Zhang J, Qiu J, Wu Y, Fang C, Sun H, Liu J. Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets.  Circulation. 2020 Jul 7;142(1):49-64. doi: 10.1161/CIRCULATIONAHA.119.043581. Epub 2020 Mar 23.Circulation. 2020. PMID: 32200651

3. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B, Liu J, Zou Q. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metab. 2019 Jun 11. pii: S1550-4131(19)30256-6. doi: 10.1016/j.cmet.2019.05.016. [Epub ahead of print]

4. Hu Z1, Qu G1, Yu X1, Jiang H2, Teng XL1, Ding L1, Hu Q1, Guo X1, Zhou Y1, Wang F1, Li HB1, Chen L1, Jiang J3, Su B4, Liu J5, Zou Q6.(2019)Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metab. 2019 Jun 11. pii: S1550-4131(19)30256-6. doi: 10.1016/j.cmet.2019.05.016. [Epub ahead of print]

5. Wang C, Cheng Y, Zhang X, Li N, Zhang L, Wang S, Tong X, Xu Y, Chen GQ, Cheng S, Fan , Liu J*.(2018)Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis. Hepatology. 2018 Dec;68(6):2239-2253.

6. Xu Y, Ouyang X, Yan L, Zhang M, Hu Z, Gu J, Fan X, Zhang L, Zhang J, Xue S, Chen G, Su B, Liu J*. (2018)Sin1 (Stress-Activated Protein Kinase-Interacting Protein)Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets. Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2793-2805.

7. Fan Xuemei, Wang Conghui, Shi Panlai, Gao Wen, Gu Jianmin, Geng Yan, Yang Wenlong, Wu Ningbo, Wang Yang, Xu Yanyan, Chen Xue, Zhang Lin, Wang Kemin, Su Bin, Liu Junling.(2018)Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice. Blood Adv. 2018 Jun 26;2(12):1439-1448.

8. Shi P, Zhang L, Zhang M, Yang W, Wang K, Zhang J, Otsu K, Huang G, Fan X, Liu J*. Platelet-Specific p38α Deficiency Improved Cardiac Function After Myocardial Infarction in Mice. Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):e185-e196.

9. Gao W, Shi P, Chen X, Zhang L, Liu J, Fan X, Luo X. Clathrin-mediated integrin αIIbβ3 trafficking controls platelet spreading. Platelets. 2017 Sep 29:1-12.

10. Wang Y, Jiang L, Mo X, Lan Y, Yang X, Liu X, Zhang J, Zhu L, Liu J, Wu X. Megakaryocytic Smad4 Regulates Platelet Function through Syk and ROCK2 Expression. Mol Pharmacol. 2017;92(3):285-296.

11. Cheng Z, Gao W, Fan X, Chen X, Mei H, Liu J, Luo X, Hu Y. Extracellular signal-regulated kinase 5 associates with casein kinase II to regulate GPIb-IX-mediated platelet activation via the PTEN/PI3K/Akt pathway. J Thromb Haemost. 2017;15(8):1679-1688.

12. Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, Poncz M, Li H, Liu T, Liu J, Essex DW. The disulfide isomerase ERp72 supports arterial thrombosis in mice. Blood. 2017;130(6):817-828.

13. Lai W, Cai Y, Zhou J, Chen S, Qin C, Yang C, Liu J, Xie X, Du C. Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation. Cell Mol Immunol. 2017;14(6):557-567.

14. Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017;28(2):194-202.

15. Zhang J, Li Z, Hu X, Su Q, He C, Liu J, Ren H, Qian M, Liu J, Cui S, Jiang W. Knockout of P2Y12 aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells. Brain Behav Immun. 2017;62:245-255.

16. Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, Kuang Y, Fei J, Liu J, Dang S, Wang Z. Palladin is involved in platelet activation and arterial thrombosis. Thromb Res. 2017;149:1-8.

17. Zhang W, Ren H, Xu C, Zhu C, Wu H, Liu D, Wang J, Liu L, Li W, Ma Q, Du L, Zheng M, Zhang C, Liu J, Chen Q. Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury. Elife. 2016 Dec 20;5. pii: e21407.

18. Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, Shao H, Zeng H, Yu Z, Xie L, Xia F, Zhang F, Liu X, Zhang Y, Jiang H, Zhu J, Wan J, Wang C, Weng W, Xie J, Tao M, Zhang CC, Liu J*, Chen GQ, Zheng J. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. J Clin Invest. 2016 Dec 1;126(12):4537-4553. doi: 10.1172/JCI87105. Epub 2016 Oct 31.

19. Dai J, Lu Y, Wang C, Chen X, Fan X, Gu H, Wu X, Wang K, Gartner TK, Zheng J, Chen G, Wang X, Liu J*. Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes. J Pathol. 2016;240(1):108-19.

20. Cheng Z, Liu J. Receptor-mediated inhibitory mechanisms and the regulation of platelet function. Sci China Life Sci. 2015;58(12):1299-301.

21. Fan X, Chen X, Wang C, Dai J, Lu Y, Wang K, Liu J, Zhang J, Wu X. Drospirenone enhances GPIb-IX-V-mediated platelet activation. J. Thromb. Haemost., 2015;13(10):1918-24.

22. Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ. Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase. PLoS One., 2015;10(8):e0135738.

23. Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X, Liu J, Kong W. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood. 2015;126(7):905-14.

24. Di C, Lin X, Zhang Y, Zhong W, Yuan Y, Zhou T, Liu J, Xia Z. Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation. J. Biol. Chem., 2015;290(20):12523-36

25. Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, Ding S, Liu J, Peng X, Gao E, Pu J, He B. Vitamin D Receptor Activation Protects against Myocardial Reperfusion Injury through Inhibition of Apoptosis and Modulation of Autophagy. Antioxid. Redox. Signal., 2015;22(8):633-50.

26. Delaney MK, Liu J, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood, 2014;124(12):1957-67.

27. Fan X, Shi P, Dai J, Lu Y, Chen X, Liu X, Zhang K, Wu X, Sun Y, Wang K, Zhu L, Zhang CC, Zhang J, Chen GQ, Zheng J, Liu J*. Paired immunoglobulin-like receptor B regulates platelet activation. Blood, 2014;124(15):2421-30.

28. Xu Z, Chen X, Zhi H, Gao J, Bialkowska K, Byzova TV, Pluskota E, White GC 2nd, Liu J, Plow EF, Ma YQ. Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice. Arterioscler. Thromb. Vasc. Biol., 2014;34(9):1961-7.

29. Wang L, Wu Y, Zhou J, Ahmad SS, Mutus B, Garbi N, Hämmerling G, Liu J, Essex DW. Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin. Blood, 2013;122(22):3642-50. 10

30. Chen X, Zhang Y, Wang Y, Li D, Zhang L, Wang K, Luo X, Yang Z, Wu Y, Liu J*. PDK1 regulates platelet activation and arterial thrombosis. Blood, 2013;121(18): 3718-26.

31. Zhang S, Ye J, Zhang Y, Xu X, Liu J, Zhang SH, Kunapuli SP, and Ding Z. P2Y(12) protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation. J. Thromb. Haemost., 2013;11(1):149-60.

32. Delaney MK, Liu J, Zheng Y, Berndt MC, and Du X. The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation. Arterioscler. Thromb. Vasc. Biol., 2012;32(11):2761-8.

33. Niu H, Chen X, Gruppo RA, Li D, Wang Y, Zhang L, Wang K, Chai W, Sun Y, Ding Z, Gartner TK, and Liu J*. Integrin αIIb-mediated PI3K/Akt activation in platelets. PLoS One., 2012;7(10):e47356. 8

34. Li D, Wang Y, Zhang L, Luo X, Li J, Chen X, Niu H, Wang K, Sun Y, Wang X, Yan Y, Chai W, Gartner TK, and Liu J*. Roles of purinergic receptor P2Y, G protein-coupled 12 in the development of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol., 2012;32(8):e81-9. 15

35. Niu H, Xu Z, Li D, Zhang L, Wang K, Taylor DB, Liu J*, and Gartner TK*. Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets. Thromb. Res., 2012;130(2):203-9.

36. Weng Z, Li D, Zhang L, Chen J, Ruan C, Chen G, Gartner TK, and Liu J*. PTEN Regulates Collagen Induced Platelet Activation. Blood, 2010;116(14):2579-81.21

37. Zhang S, Hu L, Du H, Guo Y, Zhang Y, Niu H, Jin J, Zhang J, Liu J, Zhang X, Kunapuli SP, and Ding Z. BF0801, a novel adenine derivative, inhibits platelet activation via PDE inhibition and P2Y12 antagonism. Thromb. Haemost., 2010;104(4):845-57. 9

38. Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, Gartner TK, and Li Z. A Gi-independent mechanism mediating Akt phosphorylation in platelets. J. Thromb. Haemost., 2010;8(9):2032-41. 19

39. Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Lowell CA, and Du X. An important role of the SRC family kinase LYN in stimulating platelet granule secretion. J. Biol. Chem., 2010;285(17):12559-70. 13

40. Guerrero JA, Kyei M, Russell S, Liu J, Gartner TK, Storrie B, and Ware J. Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation. Blood, 2009;114(27): 5541-6. 11

41. Flevaris P, Li Z, Zhang G, Zheng Y, Liu J, and Du X. Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK- dependent integrin outside-in retractile signaling pathway. Blood, 2009;113(4):893-901. 52

42. Liu J*, Joglekar M, Ware J, Fitzgerald MEC, Lowell CA, Berndt MC, and Gartner TK. Evaluation of the physiological significance of botrocetin/von Willebrand factor in vitro signaling. J. Thromb. Haemost., 2008;6(11):1915-22.

43. Liu J*, Jackson CW, and Gartner TK. The Src requirement for washed platelet aggregation and dense granule secretion in response to stimulation by a low level gamma-thrombin. J. Thromb. Haemost., 2008;6(6):1035-7.

44. Yin H, Liu J, Li Z, Berndt MC, Lowell CA, and Du X. Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood, 2008;112(4):1139-46. 35

45. Guerrero JA, Shafirstein G, Russell S, Varughese KI, Kanaji T, Liu J, Gartner TK, Bäumler W, Jarvis GE, and Ware J. In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation. J. Thromb. Haemost., 2008;6(4):684-91.

46. Jain S, Zuka M, Liu J, Russell S, Dent J, Forsyth J, Maruszak B, Gartner TK, Habermann BF, and Ware J. Platelet glycoprotein Ib alpha supports experimental lung metastasis. Proc. Natl. Acad. Sci. USA., 2007;104(21):9024-8. 96

47. Liu J, Ware J, Jackson CW, and Gartner TK. FcRgamma-chain dependent alphallbbeta3 elicited outside-in signaling. J. Thromb. Haemost., 2007;5(2):426-8.

48. Liu J, Ware J, Jackson CW, and Gartner TK. FcRgamma-chain signals in the absence of GPVI. J. Thromb. Haemost., 2007;5(1):201-3.

49. Liu J, Fitzgerald MEC, Berndt MC, Jackson CW, and Gartner TK. Bruton’s tyrosine kinase is essential for botrocetin/ vWf-induced signaling and GPIb-dependent thrombus formation in vivo. Blood, 2006;108(8):2596-603. 45

50. Zhao M, Liu J, Wang C, Wang L, Liu H, and Peng S. Synthesis and Biological Activity of Nitronyl Nitroxide Containing Peptides. J. Med. Chem., 2005;48(13),4285 -92.

51. Liu J, Pestina TI, Berndt MC, Steward SA, Jackson CW, and Gartner TK. Botrocetin/vWf-induced signaling through GPIb-IX-V produces TxA2 in a Ca2+ and aggregation-independent manner without utilizing other receptors. Blood, 2005;106:2750-2756. 43

52. Liu J, Jackson CW, Gruppo RA, Jennings LK, and Gartner TK. The β3 Subunit of the Integrin αIIbβ3 Regulates αIIb-mediated Outside-in Signaling. Blood, 2005;105:4345-4352. 23

53. Liu J, Pestina TI, Berndt MC, Steward SA, Jackson CW, and Gartner TK. The roles of ADP and TXA2 in botrocetin/vWf- induced aggregation of washed platelets. J. Thromb. Haemost., 2004;2:2213-2222.

54. Cho MJ, Liu J, Pestina TI, Steward SA, Thomas DW, Coffman TM, Wang D, Jackson CW, and Gartner TK. The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood, 2003;101(7):2646-51. 60

55. Cho MJ, Liu J, Pestina TI, Steward SA, Jackson CW, and Gartner TK.  AlphaIIbbeta3-mediated outside-in signaling induced by the agonist peptide LSARLAF utilizes ADP and thromboxane A2 receptors to cause alpha-granule secretion by platelets. J. Thromb. Haemost., 2003;1(2):363-73.

56. Liu J, Zhao M, Wang C, and Peng S. Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides. Bioorg Med Chem Lett., 2003;13(22):4065-4069. 12

     

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