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師資隊(duì)伍
李斌
  作者:  2018-12-31

基本信息 >>>

                       

 李斌

 分子免疫學(xué)研究組

 電話:63846590-776783

 郵箱:[email protected]


研究方向>>>

    T細(xì)胞免疫調(diào)控機(jī)制、腫瘤免疫、自身免疫及抗感染免疫。

個(gè)人簡(jiǎn)歷 >>>

上海交通大學(xué)醫(yī)學(xué)院特聘教授、博士生導(dǎo)師,上海交通大學(xué)醫(yī)學(xué)院上海免疫學(xué)研究所副所長(zhǎng),余?學(xué)者,國(guó)家自然科學(xué)基金杰出青年基金獲得者。

2001年獲得北京大學(xué)博士學(xué)位,2001年至2009年于美國(guó)賓西法尼亞大學(xué)和英國(guó)牛津大學(xué)任職博士后、研究訪問學(xué)者、高級(jí)研究助理。2009-2016年任中科院上海巴斯德研究所研究員,2016年任上海交通大學(xué)醫(yī)學(xué)院特聘教授。同時(shí)目前還任中國(guó)醫(yī)藥生物技術(shù)協(xié)會(huì)精準(zhǔn)醫(yī)療分會(huì)常務(wù)委員,中國(guó)細(xì)胞生物學(xué)學(xué)會(huì)免疫細(xì)胞生物學(xué)分會(huì)副會(huì)長(zhǎng),中華醫(yī)學(xué)生物免疫學(xué)會(huì)基礎(chǔ)免疫學(xué)分會(huì)副主任委員,中華預(yù)防醫(yī)學(xué)會(huì)生物安全與防護(hù)裝備分會(huì)青年委員會(huì)副主任委員等職。


長(zhǎng)期從事調(diào)節(jié)性T細(xì)胞相關(guān)基礎(chǔ)研究,近年來在炎癥條件下Treg細(xì)胞功能穩(wěn)定性,T細(xì)胞分化關(guān)鍵轉(zhuǎn)錄因子和廣譜宿主因子的翻譯后修飾及其相關(guān)酶類的活性調(diào)節(jié)等方面取得了突出成績(jī)。李斌課題組近年來在國(guó)際學(xué)術(shù)刊物如《Immunity》、《Nat Commun》、《PNAS》、《Cell Rep》和《J Biol Chem.》等發(fā)表論文50余篇, 其中作為通訊及共同通訊作者33篇。申請(qǐng)相關(guān)發(fā)明專利項(xiàng),已獲批發(fā)明專利項(xiàng)。近五年來先后主持科技部國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃“遺傳變異調(diào)控AS自身免疫紊亂的分子機(jī)制研究”(已結(jié)題),國(guó)家自然科學(xué)基金杰出青年基金“免疫學(xué)”(在研),國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目“炎癥因子對(duì)FOXP3+調(diào)節(jié)性T細(xì)胞分化與功能的動(dòng)態(tài)影響及其機(jī)理研究”(已結(jié)題),國(guó)家自然科學(xué)基金面上項(xiàng)目“FOXP3蛋白泛素化與去泛素化修飾調(diào)控Treg細(xì)胞功能的機(jī)理研究”(已結(jié)題)等。

科研項(xiàng)目 >>>

1. 31525008 國(guó)家自然科學(xué)基金杰出青年基金 免疫學(xué) 2016年1月-2020年12月 項(xiàng)目負(fù)責(zé)人

2. 16XD1403800 上海市科委優(yōu)秀學(xué)術(shù)帶頭人計(jì)劃 調(diào)節(jié)性T細(xì)胞功能穩(wěn)定性及其應(yīng)用 2016年5月-2019年4月 項(xiàng)目負(fù)責(zé)人

3. 31370863 國(guó)家自然科學(xué)基金面上項(xiàng)目 FOXP3蛋白泛素化與去泛素化修飾調(diào)控Treg細(xì)胞功能的機(jī)理研究 2014年1月-2017年12月 項(xiàng)目負(fù)責(zé)人

4. 81330072 國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目 炎癥因子對(duì)FOXP3+調(diào)節(jié)性T細(xì)胞分化與功能的動(dòng)態(tài)影響及其機(jī)理研究 2014年1月-2018年12月 項(xiàng)目負(fù)責(zé)人

5. 2014CB541803 科技部國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃(973計(jì)劃) 遺傳變異調(diào)控AS自身免疫紊亂的分子機(jī)制研究 2014年1月-2018年12月 項(xiàng)目負(fù)責(zé)人

6. 14JC1406100 上海市科委基礎(chǔ)研究重大項(xiàng)目 腫瘤微環(huán)境FOXP3蛋白復(fù)合體調(diào)節(jié)的機(jī)制研究 2014年7月-2017年6月 項(xiàng)目負(fù)責(zé)人

7. 31170825 國(guó)家自然科學(xué)基金面上項(xiàng)目 轉(zhuǎn)錄因子IRF4蛋白甲基化修飾及其轉(zhuǎn)錄調(diào)節(jié)功能的分子機(jī)理研究 2012年1月-2015年12月 項(xiàng)目負(fù)責(zé)人

8. 10QA1407900 上海市科委啟明星計(jì)劃 IL6信號(hào)通路調(diào)節(jié)FOXP3活性的機(jī)理研究 2010年4月-2012年3月 項(xiàng)目負(fù)責(zé)人

9. 09JC1416100 上海市科委基礎(chǔ)研究重點(diǎn)項(xiàng)目 固有免疫識(shí)別受體信號(hào)通路調(diào)節(jié)FOXP3活性的機(jī)理研究 2009年9月-2011年8月 項(xiàng)目負(fù)責(zé)人

論文與專著 >>>

1.  Fang S, Huang Y, Wang S, Zhang Y, Luo X, Liu L, Zhong S, Liu X, Li D, Liang R, Miranda P, Gu P, Zhou H, Fan X, Li B..IL-17A exacerbates fibrosis by promoting the proinflammatory and profibrotic function of orbital fibroblasts in TAO.J Clin Endocrinol Metab.,2016,101(8):2955-65. doi: 10.1210/jc.2016-1882.

2.  Li Y, Li B.A Translational Perspective of a Deubiquitinase Inhibitor in Antitumor Immunity.EBioMedicine,2016 Nov 8.

3.  Li Y, Lu Y, Wang S, Han Z, Zhu F, Ni Y, Liang R, Zhang Y, Leng Q, Wei G, Shi G, Zhu R, Li D, Wang H, Zheng SG, Xu H, Tsun A, Li B.USP21 prevents the generation of T-helper-1-like Treg cells.Nat Commun.,2016 Nov 18,doi: 10.1038/ncomms13559.

4.  Song H, Tao L, Chen C, Pan L, Hao J, Ni Y, Li D, Li B, Shi G.USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smoke extract-induced inflammation..Int J Clin Exp Pathol.,2015,Sep 1;8(9):10707-15.

5.  Ni Y, Tao L, Chen C, Song H, Li Z, Gao Y, Nie J, Piccioni M, Shi G, Li B.USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smoke extract-induced inflammation.Int J Clin Exp Pathol,2015 Sep,Sep1;8(9):10707-15.

6.  Lu Y, Cai S, Nie J, Li Y, Shi G, Hao J, Fu W, Tan H, Chen S, Li B, Xu H.The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma. Biochem Pharmacol.Biochem Pharmacol,2015,Jan 15;100:61-72. 

7.  Luo X, Nie J, Wang S, Chen Z, Chen W, Li D, Hu H, Li B.Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells.J Biol Chem,2015,Nov 27;290(48):28675-82. 

8.  Wu Y, Yang L, Zhao J, Li C, Nie J, Liu F, Zhuo C, Zheng Y, Li B, Wang Z, Xu Y.Nuclear-enriched abundant tran 1 as a diagnostic and prognostic biomarker in colorectal cancer.Mol Cancer,2015,Nov 9;14(1):191. 

9.  Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, Li Z, Lv L, Li B.TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression.J Biol Chem,2015,Nov 27;290(48):29086-94. 

10.  Nie J, Li YY, Zheng SG, Tsun A, Li B.FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases. Front Immunol.Front Immunol,2015,Sep 28;6:493. 

11.  Wu Q, Nie J, Gao Y, Xu P, Sun Q, Yang J, Han L, Chen Z, Wang X, Lv L, Tsun A, Shen J, Li B.Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1.Sci Rep,2015,Nov 9;5:16355. 

12.  Li D, Kong C, Tsun A, Chen C, Song H, Shi G, Pan W, Dai D, Shen N, Li B.MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression.Sci Rep,2015,Oct 1;5:14615. 

13.  Li B, Zheng SG..How regulatory T cells sense and adapt to inflammation.Cell Mol Immunol,2015,Sep;12(5):519-20. 

14.  Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, Wu Q, Chen Z, Gao Z, Fan H, Tsun A, Shen J, Chen G, Liu Z, Lou Z, Olsen NJ, Zheng SG, Li B.Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1.Proc Natl Acad Sci U S A,2015,Jun 23;112(25):E3246-54. 

15.  Zhou X, Tang J, Cao H, Fan H, Li B.Tissue resident regulatory T cells: novel therapeutic targets for human disease.Cell Mol Immunol,2015,Sep;12(5):543-52. 

16.  Lin F, Luo X, Tsun A, Li Z, Li D, Li B.Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation. .Int Immunopharmacol,2015,Oct;28(2):859-65. 

17.  Yang J, Xu P, Han L, Guo Z, Wang X, Chen Z, Nie J, Yin S, Piccioni M, Tsun A, Lv L, Ge S, Li B.Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORγt.J Immunol Cutting edge,2015 ,May 1;194(9):4094-7. 

18.  Li Z, Li D, Tsun A, Li B.FOXP3+ regulatory T cells and their functional regulation.Cell Mol Immunol,2015,Sep;12(5):558-65. 

19.  Han L, Yang J, Wang X, Li D, Lv L, Li B.Th17 cells in autoimmune diseases.Front Med,2015,Mar;9(1):10-9. 

20.  Zhuo C, Xu Y, Ying M, Li Q, Huang L, Li D, Cai S, Li B.FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer.Immunol Res,2015,Mar;61(3):338-47. doi: 10.1007/s12026-014-8616-y. 

21.  Xie M, Xuan B, Shan J, Pan D, Sun Y, Shan Z, Zhang J, Yu D, Li B, Qian Z.Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment.J Virol,2015,Mar;89(6):3049-61. 

22.  Piccioni M, Chen Z, Tsun A, Li B.Regulatory T-cell differentiation and their function in immune regulation.Adv Exp Med Biol,2014,841:67-97. doi: 10.1007/978-94-017-9487-9_4. 

23.  Liu BC, Zhang L, Su JS, Tsun A, Li B.Treatment of postoperative infectious complications in patients with human immunodeficiency virus infection.World J Emerg Med,2014,5(2):103-6.. 

24.  Tao L, Chen C, Song H, Piccioni M, Shi G, Li B.Deubiquitination and stabilization of IL-33 by USP21.Int J Clin Exp Pathol,2014,Jul 15;7(8):4930-7. 

25.  Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y, Li B.PIM1 kinase phosphorylates the human tranion factor FOXP3 at serine 422 to negatively regulate its activity under inflammation.J Biol Chem.,2014,Sep 26;289(39):26872-81. 

26.  Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B.The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells.J Biol Chem.,2014,Sep 12;289(37):25546-55. 

27.  Zhuo C, Li Z, Xu Y, Wang Y, Li Q, Peng J, Zheng H, Wu P, Li B, Cai S.Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival.Mol Cancer,2014,Jun 18;13:153.

28.  Pan L, Chen Z, Wang L, Chen C, Li D, Wan H, Li B, Shi G.Deubiquitination and stabilization of T-bet by USP10.Biochem Biophys Res Commun,2014,Jul 4;449(3):289-94. 

29.  Gao Y, Lin F, Xu P, Nie J, Chen Z, Su J, Tang J, Wu Q, Li Y, Guo Z, Gao Z, Li D, Shen J, Ge S, Tsun A, Li B.USP22 is a positive regulator of NFATc2 on promoting IL2 expression.FEBS Lett,2014,Mar 18;588(6):878-83. 

30.  Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J, Li B, Tsun A.Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation.J Biol Chem,2013,Dec 6;288(49):35093-103. 

31.  Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B.The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the tranion factor Foxp3.Immunity,2013,Aug 22;39(2):272-85. 

32.  Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, Lin F, Wang Y, Wei G, Yao Z, Li B.60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells.J Biol Chem,2013,May 31;288(22):15537-46. 

33.  Chen Z, Luo X, Lu Y, Zhu T, Wang J, Tsun A, Li B.Ubiquitination signals critical to regulatory T cell development and function.Int Immunopharmacol,2013,Jul;16(3):348-52. 

34.  Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G, Li B.Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the tranion factor GATA3.J Biol Chem,2013,Mar 29;288(13):9373-82. 

35.  Gao Z, Gao Y, Li Z, Chen Z, Lu D, Tsun A, Li B.Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation.Int J Clin Exp Pathol,2012,5(7):626-33.

36.  Tsun A, Chen Z, Li B..Romance of the three kingdoms: RORgammat allies with HIF1alpha against FoxP3 in regulating T cell metabolism and differentiation.Protein Cell,2011,Oct;2(10):778-81. 

37.  Tsun A, Li YY, Li B.ou, me and Foxp3: immune regulation for two.Immunotherapy,2011,Oct;3(10):1139-42. 

38.  Chen Z, Lin F, Gao Y, Li Z, Zhang J, Xing Y, Deng Z, Yao Z, Tsun A, Li B.FOXP3 and RORγt: tranional regulation of Treg and Th17.Int Immunopharmacol,2011,May;11(5):536-42. 

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2015年榮獲上海市科委優(yōu)秀學(xué)術(shù)帶頭人(A類)。