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師資隊(duì)伍
程金科
  作者:  2018-12-31

基本信息 >>>

                             

 程金科
  生物化學(xué)與分子細(xì)胞生物學(xué)系
  電話:63846590-776327
  郵箱:[email protected]

研究方向>>>

1.蛋白質(zhì)SUMO修飾與線粒體代謝調(diào)控。研究線粒體蛋白的SUMO修飾對(duì)線粒體代謝活性的調(diào)控作用與機(jī)制以及對(duì)細(xì)胞功能的影響。

2. 蛋白質(zhì)SUMO修飾與腫瘤代謝及炎癥反應(yīng)調(diào)控。研究蛋白質(zhì)SUMO修飾對(duì)腫瘤代謝及炎癥細(xì)胞活性的調(diào)控作用以及在炎癥相關(guān)疾病中的意義。

3. 蛋白質(zhì)SUMO修飾與衰老機(jī)制研究。研究SENP1-Sirt3軸在人生理與病理過(guò)程中的作用與意義。

個(gè)人簡(jiǎn)歷 >>>

程金科,研究員,博士生導(dǎo)師。現(xiàn)任上海交通大學(xué)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院長(zhǎng),生物化學(xué)與分子細(xì)胞生物學(xué)系PI,上海交通大學(xué)醫(yī)學(xué)院特聘教授。主要從事蛋白質(zhì)SUMO修飾與腫瘤、衰老及炎癥研究;調(diào)控去SUMO化蛋白酶SENP的分子機(jī)制及生物學(xué)功能;蛋白質(zhì)SUMO化修飾與代謝性疾病的研究。負(fù)責(zé)完成與正在主持的國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目、國(guó)家自然科學(xué)面上基金、國(guó)家科技部重大研發(fā)計(jì)劃等國(guó)家級(jí)項(xiàng)目14項(xiàng);上海市優(yōu)秀學(xué)科帶頭人、上海市浦江人才計(jì)劃、上海市領(lǐng)軍人才等市級(jí)項(xiàng)目12項(xiàng)。曾任中國(guó)細(xì)胞生物學(xué)會(huì)理事、中國(guó)生物化學(xué)與分子生物學(xué)會(huì)理事,目前擔(dān)任上海市生物化學(xué)與分子生物學(xué)會(huì)理事長(zhǎng)。先后以第一作者或通訊作者在Cell、Molecular CellCancer ResearchOncogene等國(guó)際期刊上發(fā)表SCI論文30余篇,研究成果獲上海市科學(xué)技術(shù)進(jìn)步獎(jiǎng)三等獎(jiǎng)。

科研項(xiàng)目 >>>

1、國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目:82030075,SENP2整合FGF21TGF-b信號(hào)調(diào)控乳腺癌細(xì)胞脂代謝并促進(jìn)EMT和腫瘤侵襲轉(zhuǎn)移的研究 2021.01.01-2025.12.31 ,負(fù)責(zé)人:程金科。

2、科技部國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目:2020YFA0803600,組織器官代謝可塑性與記憶的調(diào)控機(jī)制及其生理病理意義,2020.12.01-2025.11.30,首席負(fù)責(zé)人:程金科。

3、國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目81730082SENP1-Sirt3軸調(diào)控免疫細(xì)胞代謝重編程及在抗腫瘤免疫中的作用與機(jī)制 ,2018.01.01-2022.12.31,負(fù)責(zé)人:程金科。

4、上海市教育委員會(huì)科研創(chuàng)新計(jì)劃項(xiàng)目-重大項(xiàng)目,編號(hào):2017-01-07 -00-01-E00050,蛋白質(zhì)SUMO修飾對(duì)抗腫瘤免疫的調(diào)控作用及機(jī)制,2017/6/30-2022/6/30,負(fù)責(zé)人:程金科。

5國(guó)家自然科學(xué)基金面上項(xiàng)目:32070759代謝應(yīng)激因素促進(jìn)SENP1磷酸化并調(diào)控線粒體功能的作用與機(jī)制研究,2021.01.01-2024.12.31,負(fù)責(zé)人:王田實(shí)。

6、國(guó)家自然科學(xué)基金面上項(xiàng)目:81870321,SENP1-TFEB軸調(diào)控巨噬細(xì)胞自噬溶酶體生成的機(jī)制及與動(dòng)脈粥樣硬化的關(guān)系,2019.01.01-2022.12.31,負(fù)責(zé)人:左勇。

7、國(guó)家自然科學(xué)基金面上項(xiàng)目:81872230Nrf2 的SUMO1修飾應(yīng)答絲氨酸饑餓通過(guò)ROS-PHGDH軸調(diào)控肝癌生長(zhǎng),2019.01.01-2022.12.31,負(fù)責(zé)人:蔡蓉。

8國(guó)家自然科學(xué)基金青年項(xiàng)目:81900767,SUMO特異性蛋白酶1(SENP1)調(diào)控脂肪組織巨噬細(xì)胞活性和白色脂肪組織棕色化的作用與機(jī)制,2020.01.01-2022.12.31,負(fù)責(zé)人:田晶。

9國(guó)家自然科學(xué)基金青年項(xiàng)目:82003026,Sirt3及其去SUMO化修飾調(diào)控腫瘤浸潤(rùn)T淋巴細(xì)胞抗腫瘤能力的作用與機(jī)制,2021.01.01-2023.12.31,負(fù)責(zé)人:賀兼理。 

論文與專著 >>>

1. Cheng J, Yang J, Xia Y, Karin M, Su B. Syndergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Molecular and Cellular Biology , 20:2334-2342, 2000.

2. Yang J, Lin Y, Guo Z, Cheng J, Huang H, Liao W, Chen J, Liu ZG, Su B. Essential role of MEKK3 in TNFa induced NF-kB activation. Nature Immunology , 2:620-624, 2001.

3. Su B, Cheng J, Yang J, Guo Z. MEKK2 mediates T cell receptor signals in JNK activation and IL-2 gene expression. Journal of Biological Chemistry, 276:14784-14790, 2001.

4. Guo Z, Clydesdale G, Cheng J, Kim K, Gan L, McConkey DJ, Ullrich SE, Zhuang Y, Su B.  Disruption of MEKK2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Molecular and Cellular Biology, 22:5761-5768, 2002.

5. Huang Q, Yang J, Lin Y, Walker C, Cheng J, Liu ZG, Su B.  Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nature Immunology, 5:98-103, 2004.

6. Cheng J, Wang D, Wang Z, Yeh ETH. SENP1 Enhances Androgen Receptor-Dependent Tranion through Desumoylation of Histone Deacetylase 1. Molecular and Cellular Biology, 24:6021-6028, 2004.

7. Kho Y, Kim SC, Jiang C, Barma D, Kwon SW, Cheng J, Jaunbergs J, Weinbaum C, Tamanoi F, Falck J, Zhao Y. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. PNAS, 101:12479-12484, 2004.

8. Cheng J, Zhang D, Kim K, Zhao Y, Su B. Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation. Molecular and Cellular Biology, 25:5955-5964, 2005.

9. Veltman IM, Vreede LA, Cheng J, Looijenga LH, Janssen B, Schoenmakers EF, Yeh ETH, van Kessel AG. Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25).  Human Molecular Genetics, 14:1955-1963, 2005.

10. Cheng J, Pekins ND, Yeh ETH. Differential regulation of c-Jun-dependent tranion by SUMO-specific proteases. Journal of Biological Chemistry, 280:14492-14498, 2005.

11. Cheng J, Yu L, Zhang D, Huang Q, Spencer D, Su B. Dimerization through the catalytic domain is essential for MEKK2 activation.  Journal of Biological Chemistry, 280: 13477-13482, 2005.

12.  Cheng J, Bawa T, Lee P, Gong L, Yeh ET. Role of desumoylation in the development of prostate cancer. Neoplasia, 8:667-676, 2006.

13.  Gao F, Cheng J, Shi T, and Yeh ET. NEDDylation of a Breast Cancer–asociated Protein Recruits a Class III Histone Deacetylase that Represses NF-kB-dependent Tranion. Nature Cell Biology, 8:1171-1177, 2006.

14. Cheng J, Kang X, Zhang S and Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1a during hypoxia. Cell, 131:584-595, 2007.

15. Bawa-Khalfe T, Cheng J, Wang Z and Yeh ET. Induction of the sumo-specific protease 1 tranion by the androgen receptor in prostate cancer cells. Journal of Biological Chemistry, 282:37341-37349, 2007.

16. Huang C, Han Y, Wang Y, Sun X, Yan S, Yeh ET, Chen Y, Cang H, Li H, Shi G, Cheng J, Tang X, Yi J. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J, 28:2748-62, 2009.

17. Lu H, Liu B, You S, Xue Q, Zhang F, Cheng J, Yu B. The activity-dependent stimuli increase SUMO modification in SHSY5Y cells. Biochem Biophys Res Commun. 18;390:872-876. 2009.

18. Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J *, and Yeh ET*. SUMO-specific protease 2 is essential for suppression of polycomb group proteins mediated gene silencing during embryonic development, Molecular Cell,,38:191-201. 2010 (* correspondence author).

19.  Bawa-Khalfe T, Cheng J, Lin SH, Ittmann MM, Yeh ET. SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. J Biol Chem, 285(33):25859-66. 2010.

20. Kang X, Li J, Zou Y, Yi J, Zhang H, Cao M, Yeh ET, Cheng J. PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia. Oncogene, 29:5568-5578. 2010

21. Xu Y, Zuo Y, Zhang H, Kang X, Yue F, Yi Z, Liu M, Yeh ET, Chen G, Cheng J.Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis. J Biol Chem. 285:36682-36688. 2010.

22. Xu K, Klenk C, Liu B, Keiner B, Cheng J, Zheng BJ, Li L, Han Q, Wang C, Li T, Chen Z, Shu Y, Liu J, Klenk HD, Sun B. Modification of nonstructural protein 1 of influenza A virus by SUMO1.J Virol. 85:1086-1098. 2010.

23. Ran Y, Liu TT, Zhou Q, Li S, Mao AP, Li Y, Liu LJ, Cheng JK, Shu HB. SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. J Mol Cell Biol. 3:283-92. 2011.

24. Nguyen TV, Angkasekwinai P,Dou H, Lin FM,Lu LS, Cheng J, Chin YE, Dong C, Yeh ET. SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation. Molecular Cell. 45:210-221. 2012.

25. Zhou J, Fan Q, Zhang Z, Zou Y, Cai R, Wang Q, Zuo Y, and Cheng J. SENP1 Deficiency Promotes ER Stress-Induced Apoptosis by Increasing XBP1 SUMOylation. Cell Cycle. 11:1118-1122 . 2012.

26. Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J. SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nature Commun. 3: 911. 2012.

27. Cai R, Yu T, Huang C, Xia X, Liu X, Gu J, Xue S, Yeh ET, Cheng J. SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α. J Biol Chem. 287:44464-44470. 2012.

28. Wang Q, Xia N, Li T, Xu Y, Zou Y, Zuo Y, Fan Q, Bawa-Khalfe T, Yeh ET, Cheng J. SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene. 32:2493-2498. 2013.

29. Tang S, Huang G, Tong X, Xu L, Cai R, Li J, Zhou X, Song S, Huang C, Cheng J. Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism. PLoS One. May 14;8(5):e63965. 2013.

30. Qi Y, Zuo Y, Yeh ET, Cheng J. An essential role of SUMO-specific protease 2 in myostatin expression and myogenesis. J Biol Chem. 289:3288-3293. 2014.

31. Wang J, Liu X, Dou Z, Chen L, Jiang H, Fu C, Fu G, Liu D, Zhang J, Zhu T, Fang J, Zang J, Cheng J, Teng M, Ding X, Yao X. Mitotic regulator Mis18β interacts with and specifies the centromeric assembly of molecular chaperone holliday junction recognition protein (HJURP). J Biol Chem. 289:8326-36, 2014.

32. Han Q, Chang C, Li L, Klenk C, Cheng J, Chen Y, Xia N, Shu Y, Chen Z, Gabriel G, Sun B, Xu K. Sumoylation of influenza A virus nucleoprotein is essential for intracellular trafficking and virus growth. J Virol. 88:9379-9390. 2014

33. Liu B, Wang T, Mei W, Li D, Cai R, Zuo Y, Cheng J. SUMO-Specific Protease 1 De-SUMOylates Sharp-1 and Controls Adipocyte Differentiation. J Biol Chem. 289:22358-22364. 2014.

34. Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 83:1159-1171. 2014.

35. Gu J, Fan Y, Liu X, Zhou L, Cheng J, Cai R, Xue S. SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1α-dependent pathway. Cardiovasc Res. 104:83-92. 2014

36. Xiao N, Li H, Mei W, Cheng J. SUMOylation Attenuates Human β-arrestin 2 Inhibition of IL-1R-TRAF6 Signaling. J Biol Chem. 290:1927-35. 2015.

37. Sun H, Lu L, Zuo Y, Wang Y, Jiao Y, Zeng WZ, Huang C, Zhu MX, Zamponi GW, Zhou T, Xu TL, Cheng J, Li Y. Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation. Nat Commun. 2014 Sep 19;5:4980. doi: 10.1038/ncomms5980.

38. Cai R, Gu J, Sun H, Liu X, Mei W, Qi Y, Xue S, Ren S, Rabinowitz JE, Wang Y, Yeh ET, Cheng J. Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy. J Mol Cell Cardiol. 79:115-122. 2015.

39. Cai J, Zuo Y, Wang T, Cao Y, Cai R, Chen FL, Cheng J*, Mu J*. A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity. Oncogene. 2016 Feb 22. doi: 10.1038/onc.2016.24. [Epub ahead of print] (* correspondence author)

40.Huang C, Cheng J, Bawa-Khalfe T, Yao X, Chin YE, Yeh ET.SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability. Cell Rep. 15(1):147-57, 2016.

41.Xia N, Cai J, Wang F, Dong B, Liu S, Chen F, Cheng J, Zuo Y. SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1. Sci Rep. 2016 Sep 23; 6:34099. doi: 10.1038/srep34099

42.Dong B, Gao Y, Kang X, Gao H, Zhang J, Guo H, You MJ, Xue W, Cheng J, Huang Y. SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis. Oncotarget. 2016 7:80435-80449.

43.Bawa-Khalfe T, Yang FM, Ritho J, Lin HK, Cheng J, Yeh ET. SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget. 2016 Nov 10. doi: 10.18632/oncotarget.13283. [Epub ahead of print]

44.Wang YP*, Zhou W, Wang J, Huang X, Zuo Y, Wang TS, Gao X, Xu YY, Zou SW, Liu YB, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer. Mol Cell. 2016 64:673-687 (* correspondence author).

45.Zhang H, Wang Y, Zhu A, Huang D, Deng S, Cheng J, Zhu MX, Li Y. SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion. Cell Death Dis. 2016 Nov 24;7(11):e2484.

46.Yu T, Zuo Y, Cai R, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S, Shen L, Cheng JK*. SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop. Journal of Molecular Cell Biology , 2017, 9(2), 144–153.

47.Bo Wei, Chao Huang, Bin Liu, Yang Wang, Nansong Xia, Qiuju Fan, Guo-Qiang Chen, and Jinke Cheng*. Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability. Cancer Research.2018, 78(9):2171-2178.

48.Quan Zheng, Ying Cao, Yalan Chen, Jiqiu Wang, Qiuju Fan, Xian Huang, Yiping Wang, Tianshi Wang, Xiuzhi Wang, Jiao Ma, and Jinke Cheng*, Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1. Journal of Molecular Cell Biology. 2018, 10 (3):258-266.

49.Huang X, Zuo Y*, Wang, XZ, Wu, XF, Tan HS, Fan QJ, Dong BJ, Xue W, Chen GQ, Cheng JK*. SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function. Cancer Research, 2019,79(15): 3891-3902.

50.Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng JK*. SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Molecular Cell. 2019,75(4):823-834.

51.Liang QL; Zheng Q, Zuo Y,Chen YL, Ma J ,Ni PH*, Cheng JK*. SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation. Cell Reports, 2019, 28(8): 2004-2011.

52. Yang Wang ,Jing Tian, Chao Huang , Jiao Ma, Gaolei Hu, Yalan Chen, Tianshi Wang, Rong Cai,Yong Zuo, Hongsheng Tan, Qiuju Fan, Baijun Dong, Wei Xue, Jing Yi, Guoqiang Chen, Jun Tu and Jinke Cheng.P53 suppresses SENP3 phosphorylation to mediate G2 checkpoint.Cell Discovery ;( 2020) 6:21

53. Yun Yu ,Yalan Chen , Kexin Liu, Jinke Cheng*, Jun Tu*. SUMOylation enhances the activity of IDH2 under oxidative stress. Biochemical and Biophysical Research Communications 532 (2020)591-597.

54. Jianli He, Jinke Cheng ,and Tianshi Wang.SUMOylation-Mediated Response to Mitochondrial Stress.Int. J. Mol. Sci. 2020, 21, 5657; doi:10.3390/ijms21165657

專利與技術(shù)許可 >>>

Screening for modulators of MEKK2 and MEKK3. WO/2005/056825, 23-06-2005.

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