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師資隊伍
程金科
  作者:  2018-12-31

基本信息 >>>

                             

 程金科
  生物化學與分子細胞生物學系
  電話:63846590-776327
  郵箱:[email protected]

研究方向>>>

1.蛋白質(zhì)SUMO修飾與線粒體代謝調(diào)控,。研究線粒體蛋白的SUMO修飾對線粒體代謝活性的調(diào)控作用與機制以及對細胞功能的影響,。

2. 蛋白質(zhì)SUMO修飾與腫瘤代謝及炎癥反應調(diào)控。研究蛋白質(zhì)SUMO修飾對腫瘤代謝及炎癥細胞活性的調(diào)控作用以及在炎癥相關(guān)疾病中的意義。

3. 蛋白質(zhì)SUMO修飾與衰老機制研究,。研究SENP1-Sirt3軸在人生理與病理過程中的作用與意義。

個人簡歷 >>>

程金科,,研究員,,博士生導師?,F(xiàn)任上海交通大學醫(yī)學院基礎(chǔ)醫(yī)學院長,,生物化學與分子細胞生物學系PI,上海交通大學醫(yī)學院特聘教授,。主要從事蛋白質(zhì)SUMO修飾與腫瘤,、衰老及炎癥研究;調(diào)控去SUMO化蛋白酶SENP的分子機制及生物學功能,;蛋白質(zhì)SUMO化修飾與代謝性疾病的研究,。負責完成與正在主持的國家自然科學基金重點項目、國家自然科學面上基金,、國家科技部重大研發(fā)計劃等國家級項目14項,;上海市優(yōu)秀學科帶頭人、上海市浦江人才計劃,、上海市領(lǐng)軍人才等市級項目12項,。曾任中國細胞生物學會理事、中國生物化學與分子生物學會理事,,目前擔任上海市生物化學與分子生物學會理事長,。先后以第一作者或通訊作者在Cell、Molecular Cell,、Cancer Research,、Oncogene等國際期刊上發(fā)表SCI論文30余篇,研究成果獲上海市科學技術(shù)進步獎三等獎,。

科研項目 >>>

1,、國家自然科學基金重點項目:82030075,SENP2整合FGF21TGF-b信號調(diào)控乳腺癌細胞脂代謝并促進EMT和腫瘤侵襲轉(zhuǎn)移的研究 ,,2021.01.01-2025.12.31 ,,負責人:程金科。

2,、科技部國家重點研發(fā)計劃項目:2020YFA0803600,,組織器官代謝可塑性與記憶的調(diào)控機制及其生理病理意義,,2020.12.01-2025.11.30,首席負責人:程金科,。

3,、國家自然科學基金重點項目81730082SENP1-Sirt3軸調(diào)控免疫細胞代謝重編程及在抗腫瘤免疫中的作用與機制 ,,2018.01.01-2022.12.31,,負責人:程金科。

4,、上海市教育委員會科研創(chuàng)新計劃項目-重大項目,,編號:2017-01-07 -00-01-E00050,蛋白質(zhì)SUMO修飾對抗腫瘤免疫的調(diào)控作用及機制,,2017/6/30-2022/6/30,負責人:程金科,。

5,、國家自然科學基金面上項目:32070759代謝應激因素促進SENP1磷酸化并調(diào)控線粒體功能的作用與機制研究,,2021.01.01-2024.12.31,,負責人:王田實。

6,、國家自然科學基金面上項目:81870321,,SENP1-TFEB軸調(diào)控巨噬細胞自噬溶酶體生成的機制及與動脈粥樣硬化的關(guān)系,2019.01.01-2022.12.31,,負責人:左勇,。

7、國家自然科學基金面上項目:81872230,,Nrf2 的SUMO1修飾應答絲氨酸饑餓通過ROS-PHGDH軸調(diào)控肝癌生長,,2019.01.01-2022.12.31,負責人:蔡蓉,。

8,、國家自然科學基金青年項目:81900767,SUMO特異性蛋白酶1(SENP1)調(diào)控脂肪組織巨噬細胞活性和白色脂肪組織棕色化的作用與機制,,2020.01.01-2022.12.31,,負責人:田晶。

9,、國家自然科學基金青年項目:82003026,,Sirt3及其去SUMO化修飾調(diào)控腫瘤浸潤T淋巴細胞抗腫瘤能力的作用與機制,2021.01.01-2023.12.31,,負責人:賀兼理,。 

論文與專著 >>>

1. Cheng J, Yang J, Xia Y, Karin M, Su B. Syndergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Molecular and Cellular Biology , 20:2334-2342, 2000.

2. Yang J, Lin Y, Guo Z, Cheng J, Huang H, Liao W, Chen J, Liu ZG, Su B. Essential role of MEKK3 in TNFa induced NF-kB activation. Nature Immunology , 2:620-624, 2001.

3. Su B, Cheng J, Yang J, Guo Z. MEKK2 mediates T cell receptor signals in JNK activation and IL-2 gene expression. Journal of Biological Chemistry, 276:14784-14790, 2001.

4. Guo Z, Clydesdale G, Cheng J, Kim K, Gan L, McConkey DJ, Ullrich SE, Zhuang Y, Su B.  Disruption of MEKK2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Molecular and Cellular Biology, 22:5761-5768, 2002.

5. Huang Q, Yang J, Lin Y, Walker C, Cheng J, Liu ZG, Su B.  Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nature Immunology, 5:98-103, 2004.

6. Cheng J, Wang D, Wang Z, Yeh ETH. SENP1 Enhances Androgen Receptor-Dependent Tranion through Desumoylation of Histone Deacetylase 1. Molecular and Cellular Biology, 24:6021-6028, 2004.

7. Kho Y, Kim SC, Jiang C, Barma D, Kwon SW, Cheng J, Jaunbergs J, Weinbaum C, Tamanoi F, Falck J, Zhao Y. A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. PNAS, 101:12479-12484, 2004.

8. Cheng J, Zhang D, Kim K, Zhao Y, Su B. Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation. Molecular and Cellular Biology, 25:5955-5964, 2005.

9. Veltman IM, Vreede LA, Cheng J, Looijenga LH, Janssen B, Schoenmakers EF, Yeh ETH, van Kessel AG. Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25).  Human Molecular Genetics, 14:1955-1963, 2005.

10. Cheng J, Pekins ND, Yeh ETH. Differential regulation of c-Jun-dependent tranion by SUMO-specific proteases. Journal of Biological Chemistry, 280:14492-14498, 2005.

11. Cheng J, Yu L, Zhang D, Huang Q, Spencer D, Su B. Dimerization through the catalytic domain is essential for MEKK2 activation.  Journal of Biological Chemistry, 280: 13477-13482, 2005.

12.  Cheng J, Bawa T, Lee P, Gong L, Yeh ET. Role of desumoylation in the development of prostate cancer. Neoplasia, 8:667-676, 2006.

13.  Gao F, Cheng J, Shi T, and Yeh ET. NEDDylation of a Breast Cancer–asociated Protein Recruits a Class III Histone Deacetylase that Represses NF-kB-dependent Tranion. Nature Cell Biology, 8:1171-1177, 2006.

14. Cheng J, Kang X, Zhang S and Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1a during hypoxia. Cell, 131:584-595, 2007.

15. Bawa-Khalfe T, Cheng J, Wang Z and Yeh ET. Induction of the sumo-specific protease 1 tranion by the androgen receptor in prostate cancer cells. Journal of Biological Chemistry, 282:37341-37349, 2007.

16. Huang C, Han Y, Wang Y, Sun X, Yan S, Yeh ET, Chen Y, Cang H, Li H, Shi G, Cheng J, Tang X, Yi J. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J, 28:2748-62, 2009.

17. Lu H, Liu B, You S, Xue Q, Zhang F, Cheng J, Yu B. The activity-dependent stimuli increase SUMO modification in SHSY5Y cells. Biochem Biophys Res Commun. 18;390:872-876. 2009.

18. Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J *, and Yeh ET*. SUMO-specific protease 2 is essential for suppression of polycomb group proteins mediated gene silencing during embryonic development, Molecular Cell,,,38:191-201. 2010 (* correspondence author).

19.  Bawa-Khalfe T, Cheng J, Lin SH, Ittmann MM, Yeh ET. SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. J Biol Chem, 285(33):25859-66. 2010.

20. Kang X, Li J, Zou Y, Yi J, Zhang H, Cao M, Yeh ET, Cheng J. PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia. Oncogene, 29:5568-5578. 2010

21. Xu Y, Zuo Y, Zhang H, Kang X, Yue F, Yi Z, Liu M, Yeh ET, Chen G, Cheng J.Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis. J Biol Chem. 285:36682-36688. 2010.

22. Xu K, Klenk C, Liu B, Keiner B, Cheng J, Zheng BJ, Li L, Han Q, Wang C, Li T, Chen Z, Shu Y, Liu J, Klenk HD, Sun B. Modification of nonstructural protein 1 of influenza A virus by SUMO1.J Virol. 85:1086-1098. 2010.

23. Ran Y, Liu TT, Zhou Q, Li S, Mao AP, Li Y, Liu LJ, Cheng JK, Shu HB. SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. J Mol Cell Biol. 3:283-92. 2011.

24. Nguyen TV, Angkasekwinai P,Dou H, Lin FM,Lu LS, Cheng J, Chin YE, Dong C, Yeh ET. SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation. Molecular Cell. 45:210-221. 2012.

25. Zhou J, Fan Q, Zhang Z, Zou Y, Cai R, Wang Q, Zuo Y, and Cheng J. SENP1 Deficiency Promotes ER Stress-Induced Apoptosis by Increasing XBP1 SUMOylation. Cell Cycle. 11:1118-1122 . 2012.

26. Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J. SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nature Commun. 3: 911. 2012.

27. Cai R, Yu T, Huang C, Xia X, Liu X, Gu J, Xue S, Yeh ET, Cheng J. SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α. J Biol Chem. 287:44464-44470. 2012.

28. Wang Q, Xia N, Li T, Xu Y, Zou Y, Zuo Y, Fan Q, Bawa-Khalfe T, Yeh ET, Cheng J. SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene. 32:2493-2498. 2013.

29. Tang S, Huang G, Tong X, Xu L, Cai R, Li J, Zhou X, Song S, Huang C, Cheng J. Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism. PLoS One. May 14;8(5):e63965. 2013.

30. Qi Y, Zuo Y, Yeh ET, Cheng J. An essential role of SUMO-specific protease 2 in myostatin expression and myogenesis. J Biol Chem. 289:3288-3293. 2014.

31. Wang J, Liu X, Dou Z, Chen L, Jiang H, Fu C, Fu G, Liu D, Zhang J, Zhu T, Fang J, Zang J, Cheng J, Teng M, Ding X, Yao X. Mitotic regulator Mis18β interacts with and specifies the centromeric assembly of molecular chaperone holliday junction recognition protein (HJURP). J Biol Chem. 289:8326-36, 2014.

32. Han Q, Chang C, Li L, Klenk C, Cheng J, Chen Y, Xia N, Shu Y, Chen Z, Gabriel G, Sun B, Xu K. Sumoylation of influenza A virus nucleoprotein is essential for intracellular trafficking and virus growth. J Virol. 88:9379-9390. 2014

33. Liu B, Wang T, Mei W, Li D, Cai R, Zuo Y, Cheng J. SUMO-Specific Protease 1 De-SUMOylates Sharp-1 and Controls Adipocyte Differentiation. J Biol Chem. 289:22358-22364. 2014.

34. Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 83:1159-1171. 2014.

35. Gu J, Fan Y, Liu X, Zhou L, Cheng J, Cai R, Xue S. SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1α-dependent pathway. Cardiovasc Res. 104:83-92. 2014

36. Xiao N, Li H, Mei W, Cheng J. SUMOylation Attenuates Human β-arrestin 2 Inhibition of IL-1R-TRAF6 Signaling. J Biol Chem. 290:1927-35. 2015.

37. Sun H, Lu L, Zuo Y, Wang Y, Jiao Y, Zeng WZ, Huang C, Zhu MX, Zamponi GW, Zhou T, Xu TL, Cheng J, Li Y. Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation. Nat Commun. 2014 Sep 19;5:4980. doi: 10.1038/ncomms5980.

38. Cai R, Gu J, Sun H, Liu X, Mei W, Qi Y, Xue S, Ren S, Rabinowitz JE, Wang Y, Yeh ET, Cheng J. Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy. J Mol Cell Cardiol. 79:115-122. 2015.

39. Cai J, Zuo Y, Wang T, Cao Y, Cai R, Chen FL, Cheng J*, Mu J*. A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity. Oncogene. 2016 Feb 22. doi: 10.1038/onc.2016.24. [Epub ahead of print] (* correspondence author)

40.Huang C, Cheng J, Bawa-Khalfe T, Yao X, Chin YE, Yeh ET.SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability. Cell Rep. 15(1):147-57, 2016.

41.Xia N, Cai J, Wang F, Dong B, Liu S, Chen F, Cheng J, Zuo Y. SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1. Sci Rep. 2016 Sep 23; 6:34099. doi: 10.1038/srep34099

42.Dong B, Gao Y, Kang X, Gao H, Zhang J, Guo H, You MJ, Xue W, Cheng J, Huang Y. SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis. Oncotarget. 2016 7:80435-80449.

43.Bawa-Khalfe T, Yang FM, Ritho J, Lin HK, Cheng J, Yeh ET. SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget. 2016 Nov 10. doi: 10.18632/oncotarget.13283. [Epub ahead of print]

44.Wang YP*, Zhou W, Wang J, Huang X, Zuo Y, Wang TS, Gao X, Xu YY, Zou SW, Liu YB, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer. Mol Cell. 2016 64:673-687 (* correspondence author).

45.Zhang H, Wang Y, Zhu A, Huang D, Deng S, Cheng J, Zhu MX, Li Y. SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion. Cell Death Dis. 2016 Nov 24;7(11):e2484.

46.Yu T, Zuo Y, Cai R, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S, Shen L, Cheng JK*. SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop. Journal of Molecular Cell Biology , 2017, 9(2), 144–153.

47.Bo Wei, Chao Huang, Bin Liu, Yang Wang, Nansong Xia, Qiuju Fan, Guo-Qiang Chen, and Jinke Cheng*. Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability. Cancer Research.2018, 78(9):2171-2178.

48.Quan Zheng, Ying Cao, Yalan Chen, Jiqiu Wang, Qiuju Fan, Xian Huang, Yiping Wang, Tianshi Wang, Xiuzhi Wang, Jiao Ma, and Jinke Cheng*, Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1. Journal of Molecular Cell Biology. 2018, 10 (3):258-266.

49.Huang X, Zuo Y*, Wang, XZ, Wu, XF, Tan HS, Fan QJ, Dong BJ, Xue W, Chen GQ, Cheng JK*. SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function. Cancer Research, 2019,79(15): 3891-3902.

50.Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng JK*. SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Molecular Cell. 2019,75(4):823-834.

51.Liang QL; Zheng Q, Zuo Y,Chen YL, Ma J ,Ni PH*, Cheng JK*. SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation. Cell Reports, 2019, 28(8): 2004-2011.

52. Yang Wang ,,Jing Tian, Chao Huang , Jiao Ma, Gaolei Hu,, Yalan Chen, Tianshi Wang, Rong Cai,Yong Zuo, Hongsheng Tan, Qiuju Fan, Baijun Dong, Wei Xue, Jing Yi, Guoqiang Chen, Jun Tu and Jinke Cheng.P53 suppresses SENP3 phosphorylation to mediate G2 checkpoint.Cell Discovery ;( 2020) 6:21

53. Yun Yu ,Yalan Chen , Kexin Liu, Jinke Cheng*, Jun Tu*. SUMOylation enhances the activity of IDH2 under oxidative stress. Biochemical and Biophysical Research Communications 532 (2020)591-597.

54. Jianli He, Jinke Cheng ,and Tianshi Wang.SUMOylation-Mediated Response to Mitochondrial Stress.Int. J. Mol. Sci. 2020, 21, 5657; doi:10.3390/ijms21165657

專利與技術(shù)許可 >>>

Screening for modulators of MEKK2 and MEKK3. WO/2005/056825, 23-06-2005.

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