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師資隊伍
孫序序
  作者:  2023-03-01

基本信息 >>>

                                                               

孫序序 研究員

再生與腫瘤分子機(jī)制研究組

電話:63846590-776517

郵箱:[email protected]

研究方向>>>

課題組主要運(yùn)用基因編輯小鼠模型以及分子細(xì)胞生物學(xué)方法探索肝損傷、脂肪肝,、肝硬化以及肝癌的發(fā)病機(jī)理。

目前研究方向:

1. 探索SWI/SNF染色質(zhì)重塑復(fù)合物在肝臟再生,、脂肪肝、肝硬化和肝癌中的分子作用機(jī)制,。

2. 探索免疫治療在肝癌中的作用和分子機(jī)制,。

3. 利用肝癌類器官培養(yǎng)模型模擬肝癌發(fā)病機(jī)理并探索治療新方法。

個人簡歷 >>>

孫序序,博士,,研究員,,博士生導(dǎo)師。2010年獲得上海交通大學(xué)醫(yī)學(xué)院細(xì)胞生物學(xué)博士,。2010年至2012年曾在上海東方肝膽外科醫(yī)院及香港中文大學(xué)中藥研究所從事肝癌分子病理診斷及脂肪肝方面研究,。2013年至2018年在美國德克薩斯大學(xué)西南醫(yī)學(xué)中心從事表觀遺傳調(diào)控肝再生與肝癌方面博士后研究工作。現(xiàn)兼任中華醫(yī)學(xué)會醫(yī)學(xué)細(xì)胞生物學(xué)分會第六屆青年委員會委員,、中國細(xì)胞生物學(xué)會會員等職務(wù)。相關(guān)研究成果發(fā)表在Cell Stem Cell, Cancer Cell, EMBO J, Elife, Hepatology, Cell Reports等期刊上,。

科研項目 >>>

31970587,,國家自然科學(xué)基金面上項目,染色質(zhì)重塑因子ARID1A四種熱點(diǎn)突變在肝癌中的功能及分子機(jī)制研究,,2020.1-2023.12,,60萬元,主持人

32170609,,國家自然科學(xué)基金面上項目,,染色質(zhì)重塑基因Arid1a缺失促進(jìn)肝細(xì)胞向肝內(nèi)膽管癌惡性轉(zhuǎn)化的分子機(jī)制研究,2022.1-2025.12,58萬元,,主持人

2021YFC2700802,,國家重點(diǎn)研發(fā)計劃,肝豆?fàn)詈俗冃曰蛑委熕幬镅邪l(fā)與臨床轉(zhuǎn)化,,2021.12 - 2024 .11,,37.35萬元,課題骨干

論文與專著 >>>

 

1. Xubiao Wei, Lulu Zhang, Yinlong Yang, Yanfei Hou, Yifang Xu, Zhimeng Wang, Huili Su, Fangping Han,Jing Han, Peiyuan Liu, Shuiqing Hu, Matthew D. Koci, Xuxu Sun, Conggang Zhang. LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity. Cell Reports 2022 May 31;39(9):110880.

2. Fei Chen, Hongyu Yan, Chu Guo, Huiqin Zhu, Jing Yi, Xuxu Sun, Jie Yang. Assessment of SENP3-interacting proteins in hepatocytes treated with diethylnitrosamine by BioID assay. Acta Biochimica et Biophysica Sinica. 2021 Aug 31;53(9):1237-1246.

3. Ruogu Pan, Zhiqing Yuan, Yingbin Liu, Xuxu Sun, Guiyang Wang, Xiaopen Wang, Junwen Qu, Jian Wang, Jie Yang, Yuzheng Zhao, Yi Yang, Kewei Li. A redox probe screens MTHFD1 as a determinant of gemcitabine chemoresistance in cholangiocarcinoma. Cell Death Discov 2021 May 1;7(1):89.

4. Ming Xiao, Qi Bian, Yimin Lao, Jing Yi, Xueqing Sun, Xuxu Sun#(co-corresponding author), Jie Yang#. SENP3 loss promotes M2 macrophage polarization and breast cancer progression. Molecular oncology 2021 May, 1878-0261.

5. Zixi Wang, Kenian Chen, Yuemeng Jia, Jen-Chieh Chuang, Xuxu Sun, Yu-Hsuan Lin, Cemre Celen, Lin Li, Fang Huang, Xin Liu, Diego H. Castrillon, Tao Wang, Hao Zhu. Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes. Nature Cancer 2020 September, 1, 909–922.

6. Yongxing Zhang, Kai Yang, Jie Yang, Yimin Lao, Lianfu Deng, Guoying Deng, Jing Yi#, Xuxu Sun# (co-corresponding author), Qiugen Wang#. SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes. Cell Reports 2020 February 11; 30, 1951–1963. e4.

7. Sam C Wang, Ibrahim Nassour, Shu Xiao, Shuyuan Zhang, Xin Luo, Jeon Lee, Lin Li, Xuxu Sun, Liem H Nguyen, Jen-Chieh Chuang, Lan Peng, Scott Daigle, Jeanne Shen, Hao Zhu. SWI/SNF component ARID1A restrains pancreatic neoplasia formation. Gut 2019 Jul;68(7):1259-1270.

8. Austin Moore,Linwei Wu, Jen-Chieh Chuang, Xuxu Sun, Xin Luo, Purva Gopal, Lin Li, Cemre Celen, Michael Zimmer, Hao Zhu. Arid1a loss drives non-alcoholic steatohepatitis in mice via epigenetic dysregulation of hepatic lipogenesis and fatty acid oxidation. Hepatology 2019 May; 69(5):1931-1945.

9. Xuxu Sun, Sam C. Wang, Yonglong Wei, Xin Luo, Yuemeng Jia, Lin Li, Purva Gopal, Min Zhu, Ibrahim Nassour, Jen-Chieh Chuang, Thomas Maples, Cemre Celen, Liem H. Nguyen, Linwei Wu, Shunjun Fu, Weiping Li, Lijian Hui, Feng Tian, Yuan Ji, Shuyuan Zhang, Mahsa Sorouri, Tae Hyun Hwang, Lynda Letzig, Laura James, Zixi Wang, Adam C. Yopp, Amit G. Singal, Hao Zhu. Arid1a has context-dependent oncogenic and tumor suppressor functions in liver cancer. Cancer Cell 2017, Nov 13; 32 (5), p574–589. e6.

10. Cemre Celen, Jen-Chieh Chuang, Xin Luo, Nadine Nijem, Angela K Walker, Fei Chen, Shuyuan Zhang, Andrew S Chung, Liem H Nguyen, Ibrahim Nassour, Albert Budhipramono, Xuxu Sun, Levinus A Bok, Meriel McEntagart, Evelien F Gevers, Shari G Birnbaum, Amelia J Eisch, Craig M Powell, Woo-Ping Ge, Gijs WE Santen, Maria Chahrour, and Hao Zhu. Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. ELife 2017 Jul 11; 6. pii: e25730.  

11. Kai Yang, Ming Wang, Yuzheng Zhao, Xuxu Sun, Yi Yang, Xie Li, Aiwu Zhou, Huilin Chu, Hu Zhou, Jianrong Xu, Mian Wu, Jie Yang,a, and Jing Yi. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nat Communication. 2016 Nov 25; 7:13599.

12. Xuxu Sun, Jen-Chieh Chuang, Mohammed Kanchwala, Linwei Wu, Cemre Celen, Lin Li, Hanquan Liang, Shuyuan Zhang, Thomas Maples, Liem H. Nguyen, Sam C. Wang, Robert A.J. Signer, Mahsa Sorouri, Ibrahim Nassour, Xin Liu, Jian Xu, Meng Wu, Yong Zhao, Yi-Chun Kuo, Zhong Wang, Chao Xing, Hao Zhu. Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration. Cell Stem Cell 2016 Apr 7; 18(4):456-466.

13. Chi-Man Koon, Chun-Hay Ko, Xu-Xu Sun, Sandy Wan-Heng Hoi, Jacqueline Chor-Wing Tam, David Wing-Shing Cheung, King-Fai Cheng, Suet-Yee Pang, Wing-Man Lo, Ping Chook, Clara Bik-San Lau, Wai-Yee Chan, Ping-Chung Leung, Timothy Chi-Yui Kwok, Kwok-Pui Fung. Gene Expression Profiling on the Molecular Action of Danshen-Gegen Formula in a Randomized Placebo-Controlled Trial of Postmenopausal Women with Hypercholesterolemia. Evid Based Complement Alternat Med 2013, 2013: 703705.

14. Wenming Cong, Hui Dong, Lu Tan, Xuxu Sun, Mengchao Wu. Surgicopathological classification of hepatic space-occupying lesions: a single-center experience with literature review. World J Gastroenterology 2011, 17(19):2372-8.

15. Shan Yan*, Xuxu Sun*(Co-first author), Binggang Xiang, Hui Cang, Xunlei Kang, Yuying Chen, Hui Li, Guiying Shi, Edward T H Yeh, Beilei Wang, Xiangrui Wang, Jing Yi. Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. EMBO J 2010 Nov17; 29(22):3773-86.  

16. Yan Han, Chao Huang, Xuxu Sun, Binggang Xiang, Edward T H Yeh, Yuying Chen, Hui Li, Guiying Shi, Hui Cang, Yueping Sun, Jian Wang, Wei Wang, Fei Gao, Jing Yi. SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem 2010 Apr23; 285(17): 12906-15.

17. Chao Huang, Yan Han, Yumei Wang, Xuxu Sun, Shan Yan, Edward T H Yeh, Yuying Chen, Hui Cang, Hui Li, Guiying Shi, Jinke Cheng, Xueming Tang, Jing Yi. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J 2009 Sep 16; 28(18): 2748-62.

18. Yong Zuo, Binggang Xiang, Jie Yang, Xuxu Sun, Hui Cang, Ying Wang, Jing Yi. Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1. Cell Res 2009 Apr; 19(4): 449-57.