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程金科，研究員,博士生導師，上海交通大學特聘教授。主要從事蛋白質SUMO修飾與腫瘤、衰老及炎癥研究；調(diào)控去SUMO化蛋白酶SENP的分子機制及生物學功能；蛋白質SUMO化修飾與代謝性疾病的研究。負責完成與正在主持的國家自然科學基金重點項目、國家自然科學面上基金、國家科技部重大研究計劃、教育部等國家級項目15項；上海市優(yōu)秀學科帶頭人、上海市浦江人才計劃、上海市領軍人才等市級項目12項。曾任中國細胞生物學會理事、中國生物化學與分子生物學會理事，目前擔任上海市生物化學與分子生物學會理事長。先后以第一作者或通訊作者在Cell、Molecular Cell、Cancer Research、Oncogene等國際期刊上發(fā)表SCI論文30余篇，研究成果獲上海市科學技術進步獎三等獎。

1. 82230049，SENP1-Sirt3軸調(diào)控線粒體代謝重編程及抗組織器官衰老的作用與機制研究，國家自然科學基金重點項目，2023/01 -2027/12，261萬元，項目負責人

2. 82030075，SENP2整合FGF21和TGF-b信號調(diào)控乳腺癌細胞脂代謝并促進EMT和腫瘤侵襲轉移的研究。國家自然科學基金重點項目，2021/01 -2025/12 ，297萬元，項目負責人

3.2020YFA0803600，組織器官代謝可塑性與記憶的調(diào)控機制及其生理病理意義，科技部國家重點研發(fā)計劃，2020.12.01-2025.11.30，2425萬元 （總項目），698萬元（課題三），首席及課題三負責人

4.81730082，SENP1-Sirt3軸調(diào)控免疫細胞代謝重編程及在抗腫瘤免疫中的作用與機制。國家自然科學基金重點項目,2018/01 -2022/12，290萬，項目負責人

5.2017-01-07 -00-01-E00050，蛋白質SUMO修飾對抗腫瘤免疫的調(diào)控作用及機制，上海市教育委員會科研創(chuàng)新計劃項目-重大項目，2017/6/29-2022/6/29,300萬，項目負責人

6.81430069，SUMO特異性蛋白酶3調(diào)控細胞分裂的作用及與腫瘤發(fā)生的關系。國家自然科學基金重點項目,2015/01 -2019/12，320萬，項目負責人

7.91229202，SUMO特異性蛋白酶1在腫瘤炎癥反應中的調(diào)節(jié)作用及分子基礎,國家自然科學基金重點項目，2013/01 -2016/12，300萬，項目負責人

8.91019021，SUMO特異性蛋白酶2在心臟發(fā)育過程中的作用與調(diào)控機制，國家自然科學重大研究計劃重點支持項目，2011/01 -2014/12，200萬，項目負責人

1. Cheng J, Kang X, Zhang S and Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1a during hypoxia. Cell, 131:584-595, 2007.

2. Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J ^*, and Yeh ET^*. SUMO-specific protease 2 is essential for suppression of polycomb group proteins mediated gene silencing during embryonic development, Molecular Cell,，38：191-201. 2010.

3.Kang X, Li J, Zou Y, Yi J, Zhang H, Cao M, Yeh ET, Cheng J^*. PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia. Oncogene, 29:5568-5578. 2010.

4. Wang Q, Xia N, Li T, Xu Y, Zou Y, Zuo Y, Fan Q, Bawa-Khalfe T, Yeh ET, Cheng J^*. SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene. 32:2493-2498. 2013.

5. Cai J, Zuo Y, Wang T, Cao Y, Cai R, Chen FL, Cheng J*, Mu J*. A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity. Oncogene. 2016 Feb 22. doi: 10.1038/onc.2016.24.

6. Xia N, Cai J, Wang F, Dong B, Liu S, Chen F, Cheng J^*, Zuo Y. SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1. Sci Rep. 2016 Sep 23; 6:34099. doi: 10.1038/srep34099

7. Wang YP*, Zhou W, Wang J, Huang X, Zuo Y, Wang TS, Gao X, Xu YY, Zou SW, Liu YB, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer. Mol Cell. 2016 64:673-687.

8. Yu T, Zuo Y, Cai R, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S, Shen L, Cheng JK*. SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop. Journal of Molecular Cell Biology , 2017, 9(2), 144–153.

9. Bo Wei, Chao Huang, Bin Liu, Yang Wang, Nansong Xia, Qiuju Fan, Guo-Qiang Chen, and Jinke Cheng*. Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability. Cancer Research.2018, 78(9):2171-2178.

10. Huang X, Zuo Y*, Wang, XZ, Wu, XF, Tan HS, Fan QJ, Dong BJ, Xue W, Chen GQ, Cheng JK*. SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function. Cancer Research, 2019,79(15): 3891-3902.

11. Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng JK*. SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Molecular Cell. 2019,75(4):823-834.

12. Liang QL; Zheng Q, Zuo Y,Chen YL, Ma J ,Ni PH*, Cheng JK*. SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation. Cell Reports, 2019, 28(8): 2004-2011.

13. Yang Wang ，Jing Tian, Chao Huang , Jiao Ma, Gaolei Hu， Yalan Chen, Tianshi Wang, Rong Cai,Yong Zuo, Hongsheng Tan, Qiuju Fan, Baijun Dong, Wei Xue, Jing Yi, Guoqiang Chen, Jun Tu and Jinke Cheng.P53 suppresses SENP3 phosphorylation to mediate G2 checkpoint.Cell Discovery ；( 2020) 6:21

14. Xun Shangguan , Jianli He, Zehua Ma, Weiwei zhang , Yiyi Ji, Kai Shen, Zhiying Yue, Wenyu Li ,Zhixiang Xin, Quan Zheng, Ying Cao, Jiahua Pan, Baijun Dong, Jinke Cheng*, Qi Wang* &Wei Xue*，SUMOylation Controls the Binding of Hexokinase 2 to Mitochondria and Protects against Prostate Cancer Tumorigenesis.Nature Communications. 2021 Mar 22;12(1):1812.

15. Jianli He^#, Xun Shangguan^# , Wei Zhou, Ying Cao, Quan Zheng, Jun Tu, Gaolei Hu, Zi Liang,Cen Jiang, Liufu Deng , Shengdian Wang, Wen Yang, Yong Zuo, Jiao Ma, Rong Cai, Yalan Chen,Qiuju Fan, Baijun Dong , Wei Xue, Hongsheng Tan, Yitao Qi, Jianmin Gu, Bing Su, Y. Eugene Chin,Guoqiang Chen , Qi Wang*, Tianshi Wang* & Jinke Cheng*. Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. Nature Communications , (2021) 12:4371.

16. Wei Zhou,Gaolei Hu,Jianli He,Tianshi Wang,Yong Zuo,Ying Cao,Quan Zheng,Jun Tu,Jiao Ma,Rong Cai,Yalan Chen,Qiuju Fan,Baijun Dong,Hongsheng Tan,Qi Wang,Wei Xue*,Jinke Cheng*. SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization. Cell Report.2022 Apr 12;39(2):110660.

17. Cen Jiang, Jianli He, Sunwang Xu*, Qi Wang,and Jinke Cheng*.NR4A1 promotes LEF1 expression in the pathogenesis of papillary thyroid cancer.Cell Death Discovery (2022) 8:46.

18. Gaolei Hu, Yalan Chen, Xinyu Yang, Yang Wang, Jianli He, Tianshi Wang , Qiuju Fan, Liufu Deng, Jun Tu,Hongsheng Tan* and Jinke Cheng*.Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity.Cell Death and Disease (2022) 13:640.

1.2020年國務院特殊津貼

2.上海交通大學2020年度教學成果獎特等獎

3.2016年度上海領軍人才

4.2013年度上海市科學技術獎三等獎

5.2011年度上海市優(yōu)秀學術帶頭人