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師資隊(duì)伍
陳磊
  作者:  2018-12-31
基本信息 >>>    
                                                                                                                               
  陳磊
  基因組與微生物組學(xué)研究組
  電話:63846590-776734
  郵箱:[email protected]

研究方向 >>>

長期從事生物信息方面的研究工作,研究重點(diǎn)一方面是基因測(cè)序數(shù)據(jù)的挖掘與分析,,另一方面是微生物組與疾病的研究,。

1. 基因測(cè)序相關(guān)的生物信息學(xué)。

2. 利用基因測(cè)序研究人體共生微生物群體,,研究它們與人類慢性疾病的關(guān)系,。

3. 腸道微生態(tài)與免疫系統(tǒng)的相互作用。

個(gè)人簡歷 >>>

陳磊研究員,,基因組與微生物組學(xué)課題組組長,。2010年獲得貝勒醫(yī)學(xué)院博士學(xué)位,;2010-2014在圣路易斯華盛頓大學(xué)從事博士后研究;2014-2016在美國杰克遜基因組醫(yī)學(xué)實(shí)驗(yàn)室擔(dān)任生物信息分析師;2016加入我院,,任“基因組與微生物組學(xué)”課題組組長,。陳磊課題組長期從事生物信息方面的研究工作,研究重點(diǎn)一方面是基因測(cè)序數(shù)據(jù)的挖掘與分析,,另一方面是微生物組與疾病的研究,相關(guān)成果發(fā)表在Nature,,Science,GenomeResearch 等雜志上,。

論文與專著 >>>

1.Zhang T, Kayani M, Hong L, Zhang C, Zhong J, Wang Z*, Chen L*. Dynamics of the salivary microbiome during different phases of Crohn’s disease. Frontiers in Cellular and Infection Microbiology, 2020 Oct 6;10:544704.

2.Caixia G, Mingnan Z, Lei C*. The Comparison of Two Single-cell Sequencing Platforms: BD Rhapsody and 10x Genomics Chromium. Current Genomics, 2020, 21.

3.Li, Q., Chang, Y., He, Z., Chen, L.*, & Zhou, X*. (2019). Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in RAW264.7 cells. Journal of Cellular Physiology, 234(12), 23337-23348.

4.Chen K, Chen L#, Fan X, Wallis J, Ding L, Weinstock G. TIGRA: a targeted iterative graph routing assembler for breakpoint assembly. Genome Res. 2014 Feb;24(2):310-7.

5.Zhou W, Sailani MR, Contrepois K, Zhou Y, Ahadi S, Leopold SR, Zhang MJ, Rao V, Avina M, Mishra T, Johnson J, Lee-McMullen B, Chen S, Metwally AA, Tran TDB, Nguyen H, Zhou X, Albright B, Hong BY, Petersen L, Bautista E, Hanson B, Chen L, Spakowicz D, Bahmani A, Salins D, Leopold B, Ashland M, Dagan-Rosenfeld O, Rego S, Limcaoco P, Colbert E, Allister C, Perelman D, Craig C, Wei E, Chaib H, Hornburg D, Dunn J, Liang L, Rose SMS, Kukurba K, Piening B, Rost H, Tse D, McLaughlin T, Sodergren E, Weinstock GM, Snyder M. Longitudinal multi-omics of host-microbe dynamics in prediabetes. Nature. 2019 May;569(7758):663-671.

6.Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B, Liu J, Zou Q. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metab. 2019 Aug 6;30(2):290-302.e5.

7.Cignarella F, Cantoni C, Ghezzi L, Chen, L.,,et al. Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota[J]. Cell Metabolism, 2018, 27(6).

8.Petersen LM, Bautista EJ, Nguyen H, Hanson BM, Chen L, Lek SH, Sodergren E, Weinstock GM. Community characteristics of the gut microbiomes of competitive cyclists. Microbiome. 2017 Aug 10;5(1):98.