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師資隊(duì)伍
李斌
  作者:  2018-12-31

基本信息 >>>

                                                                                                                                                                                                                 

 李斌

 分子免疫學(xué)研究組

 電話:63846590-776783 

 郵箱:[email protected]

研究方向>>>

免疫調(diào)節(jié),、FOXP3+Treg,、腫瘤免疫,、自身免疫,、移植免疫,、抗感染免疫及免疫代謝與疾病

個(gè)人簡歷 >>>

李斌,,二級(jí)研究員,,教授,博士生導(dǎo)師

分子與免疫學(xué)課題組課題組長

上海市免疫學(xué)研究所副所長

上海交通大學(xué)特聘教授

國家基金委免疫學(xué)杰青

上海市領(lǐng)軍人才

上海市優(yōu)秀學(xué)科帶頭人


1992.9-1996.7 安徽師范大學(xué),,學(xué)士

1996.9-2001.7 北京大學(xué),,博士

2001.9-2006.7 賓夕法尼亞大學(xué)醫(yī)學(xué)院,博士后

2002.10-2003.7 牛津大學(xué),,訪問學(xué)者

2006.7-2009.2 賓夕法尼亞大學(xué)醫(yī)學(xué)院,,高級(jí)研究助理

2009.2-2016.9 中國科學(xué)院上海巴斯德研究所,研究員,、博士生導(dǎo)師,,課題組長

2016.9-至今 上海交通大學(xué)醫(yī)學(xué)院上海免疫學(xué)研究所,資深研究員,、余?學(xué)者,、特聘教授,科研副所長,,分子免疫學(xué)課題組組長

科研項(xiàng)目 >>>

1. 國家自然科學(xué)基金重點(diǎn)項(xiàng)目,,32130041,“系統(tǒng)性鑒定脂肪組織調(diào)節(jié)性T細(xì)胞亞型及其生理功能”,,20221-202612月,291萬元,,項(xiàng)目主持

2. 科技部重點(diǎn)研發(fā)專項(xiàng),,2019YFA0906102,“抵抗Treg 抑制的工程性CAR-T 細(xì)胞構(gòu)建及功能研究”,,20201-202412月,,217萬元,,課題負(fù)責(zé)

3. 國家自然科學(xué)基金中波國際合作項(xiàng)目,31961133011,,“Th17/Treg免疫平衡調(diào)控抗腫瘤免疫疾病的新策略研究,,20197-20226月,140萬元,,項(xiàng)目主持

4. 國家自然科學(xué)基金重點(diǎn)項(xiàng)目,,81810051“Th17/Treg免疫平衡調(diào)控自身免疫疾病的新策略研究,,20191-202212月,,294萬,項(xiàng)目負(fù)責(zé)人

5. 國家自然科學(xué)基金杰出青年,,31525008,,分子免疫學(xué)20161-202012月,,400萬元,,項(xiàng)目主持

6. 國家自然科學(xué)基金重點(diǎn)項(xiàng)目,81330072,,炎癥因子對(duì)FOXP3+調(diào)節(jié)性T細(xì)胞分化與功能的動(dòng)態(tài)影響及其機(jī)理研究,,20141-201812月,290萬元,,項(xiàng)目主持

7. 國家自然科學(xué)基金面上項(xiàng)目,,31370863“FOXP3蛋白泛素化與去泛素化修飾調(diào)控Treg細(xì)胞功能的機(jī)理研究,,20141-201712月,,80萬元,項(xiàng)目主持

8. 國家自然科學(xué)基金面上項(xiàng)目,,31170825,,轉(zhuǎn)錄因子IRF4蛋白甲基化修飾及其轉(zhuǎn)錄調(diào)節(jié)功能的分子機(jī)理研究20121-201512月,,65萬元,,項(xiàng)目主持

9. 國家自然科學(xué)基金面上項(xiàng)目,30972702,,調(diào)節(jié)性T細(xì)胞中FOXP3蛋白修飾及轉(zhuǎn)錄復(fù)合體動(dòng)態(tài)組裝的機(jī)理研究,,200910-201210月,32萬元,,項(xiàng)目主持

10.國家重點(diǎn)基礎(chǔ)研究計(jì)劃(973計(jì)劃),,2014CB54180320141-201812月,,260萬元,,課題負(fù)責(zé)人

論文與專著 >>>

1Liu Q, Zhu F, Liu X, Lu Y, Yao K, Tian N, Tong L, Figge DA, Wang X, Han Y, Li Y, Zhu Y, Hu L, Ji Y, Xu N, Li D, Gu X, Liang R, Gan G, Wu L, Zhang P, Xu T, Hu H, Hu Z, Xu H, Ye D, Yang H, Li B, Tong X. Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics. Nat Metab. 2022 May 23. doi: 10.1038/s42255-022-00575-z.

2Li Y, Lu Y, Lin SH, Li N, Han Y, Huang Q, Zhao Y, Xie F, Guo Y, Deng B, Tsun A, Du J, Li D, Sun J, Shi G, Zheng F, Su X, Duan S, Zheng SG, Wang G, Tong X, Li B. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol. 2021 Sep;22(9):1175-1185.

3Lu Y, Li Y, Liu Q, Tian N, Du P, Zhu F, Han Y, Liu X, Liu X, Peng X, Wang X, Wu Y, Tong L, Li Y, Zhu Y, Wu L, Zhang P, Xu Y, Chen H, Li B, Tong X. MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment. Gastroenterology. 2021 Aug;161(2):575-591.e16.

4Cheng H, Wang L, Yang B, Li D, Wang X, Liu X, Tian N, Huang Q, Feng R, Wang Z, Liang R, Dai SM, Lv L, Wu J, Zang YS, Li B. Cutting Edge: Inhibition of Glycogen Synthase Kinase 3 Activity Induces the Generation and Enhanced Suppressive Function of Human IL-10+ FOXP3+-Induced Regulatory T Cells. J Immunol. 2020 Sep 15;205(6):1497-1502.

5Yang J, Wei P, Barbi J, Huang Q, Yang E, Bai Y, Nie J, Gao Y, Tao J, Lu Y, Xie C, Hou X, Ren J, Wu X, Meng J, Zhang Y, Fu J, Kou W, Gao Y, Chen Z, Liang R, Tsun A, Li D, Guo W, Zhang S, Zheng SG, Niu J, Galardy P, Tong X, Shi G, Li H, Pan F, Li B. The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation. EMBO Rep. 2020 Sep 3;21(9):e50308.

6Yi G, Zhao Y, Xie F, Zhu F, Wan Z, Wang J, Wang X, Gao X, Cao L, Li X, Chen C, Kuang Y, Qiu X, Yang H, Wang J, Su B, Chen L, Zhang W, Hou Y, Xu X, He Y, Tsun A, Liu X, Li B, Single-cell RNA-seq unveils critical regulators of human FOXP3+ regulatory T cell stability. Science Bulletin, 2020, 65(13):1114-1124.

7Yi G, Guo S, Liu W, Wang H, Liu R, Tsun A, Jin G, Li B. Identification and functional analysis of heterogeneous FOXP3+ Treg cell subpopulations in human pancreatic ductal adenocarcinoma. Science Bulletin, 2018,63(15):972-981.

8Fang, S. Huang, Y. Wang, N. Zhang, S. Zhong, S. Li, Y. Sun, J. Liu, X. Wang, Y. Gu, P. Li, B. Zhou, H. Fan, X. Insights into Local Orbital Immunity: Evidence for the Involvement of the Th17 Cell Pathway in Thyroid-Associated Ophthalmopathy. J Clin Endocrinol Metab., 2018, doi: 10.1210.

9Fang S, Huang Y, Zhong S, Li Y, Zhang Y, Li Y, Sun J, Liu X, Wang Y, Zhang S, Xu T, Sun X, Gu P, Li D, Zhou H, Li B, Fan X. Regulation of Orbital Fibrosis and Adipogenesis by Pathogenic Th17 Cells in Graves Orbitopathy. J Clin Endocrinol Metab., 2017,102(11):4273-4283.

10Fang S, Huang Y, Wang S, Zhang Y, Luo X, Liu L, Zhong S, Liu X, Li D, Liang R, Miranda P, Gu P, Zhou H, Fan X, Li B. IL-17A exacerbates fibrosis by promoting the proinflammatory and profibrotic function of orbital fibroblasts in TAO. J Clin Endocrinol Metab., 2016,101(8):2955-65.

11Shan J, Zhao B, Shan Z, Nie J, Deng R, Xiong R, Tsun A, Pan W, Zhao H, Chen L, Jin Y, Qian Z, Lui K, Liang R, Li D, Sun B, Lavillette D, Xu K, Li B. Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation. PLoS Pathog., 2017,13(12):e1006773.

12Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J, Li B, Tsun A. Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation. J Biol Chem., 2013,288(49):35093-103.

13Luo X, Nie J, Wang S, Chen Z, Chen W, Li D, Hu H, Li B. Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells. J Biol Chem., 2016,291(3):1201.

14Li Y, Lu Y, Wang S, Han Z, Zhu F, Ni Y, Liang R, Zhang Y, Leng Q, Wei G, Shi G, Zhu R, Li D, Wang H, Zheng SG, Xu H, Tsun A, Li B. USP21 prevents the generation of T-helper-1-like Treg cells. Nat Commun., 2016,7: 13559.

15Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, Wu Q, Chen Z, Gao Z, Fan H, Tsun A, Shen J, Chen G, Liu Z, Lou Z, Olsen NJ, Zheng SG, Li B. Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1. Proc Natl Acad Sci U S A., 2015,112(25): E3246-54.

16Yang J, Xu P, Han L, Guo Z, Wang X, Chen Z, Nie J, Yin S, Piccioni M, Tsun A, Lv L, Ge S, Li B. Cutting edge: Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORγt. J Immunol. 2015 May 1;194(9):4094-7.

17Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, Li Z, Lv L, Li B. TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression. J Biol Chem., 2015,290(48):29086-94.

18Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y, Li B. PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation. J Biol Chem., 2014,289(39):26872-81.

19Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B. The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells. J Biol Chem., 2014,289(37):25546-55.

20Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, Lin F, Wang Y, Wei G, Yao Z, Li B. 60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells. J Biol Chem. 2013 May 31;288(22):15537-46.

21Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G, Li B. Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3. J Biol Chem. 2013 Mar 29;288(13):9373-82.

22Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity, 2013,39(2):272-85.

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2018 上海醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng)

2018 國家科學(xué)技術(shù)進(jìn)步二等獎(jiǎng)

2016 上海醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng)

2015 中科院優(yōu)秀研究生指導(dǎo)教師獎(jiǎng)

2012 中華醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng)