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   聶紅

   自身免疫與免疫干預(yù)研究組

   電話：63846590 - 776364

   郵箱：[email protected]

自身免疫病和腫瘤的發(fā)生機(jī)制及免疫干預(yù)，重點(diǎn)探索細(xì)胞因子和調(diào)節(jié)性T細(xì)胞在自身免疫病發(fā)生發(fā)展中的作用及腫瘤微環(huán)境中免疫細(xì)胞與腫瘤細(xì)胞的互作機(jī)制，并通過對(duì)自身免疫病等動(dòng)物模型有良好療效的天然產(chǎn)物直接靶標(biāo)的研究，發(fā)現(xiàn)疾病治療新靶點(diǎn)，研究治療新策略。

聶紅，研究員，博士生導(dǎo)師，課題組長(zhǎng)。1993年、1996年、2004年分別獲上海第二醫(yī)科大學(xué)學(xué)士學(xué)位、碩士學(xué)位、博士學(xué)位。1996年起任上海交通大學(xué)醫(yī)學(xué)院助教、助研、副研究員、研究員，2016年起任上海交通大學(xué)醫(yī)學(xué)院上海市免疫學(xué)研究所課題組長(zhǎng)，長(zhǎng)期從事自身免疫病發(fā)病機(jī)制與免疫干預(yù)策略研究，在小分子化合物治療自身免疫病的機(jī)制研究中發(fā)現(xiàn)新的治療靶點(diǎn)，近年來(lái)開展腫瘤發(fā)生機(jī)制及治療新靶點(diǎn)探索。主持國(guó)家自然科學(xué)基金等科研項(xiàng)目，參與國(guó)家重點(diǎn)研發(fā)計(jì)劃課題，研究成果發(fā)表在Theranostics，Immunology，Nature Medicine等雜志。

1. 上海市科委“科技創(chuàng)新行動(dòng)計(jì)劃”自然科學(xué)基金項(xiàng)目，PRMT5促進(jìn)宮頸癌PD-L1表達(dá)及抑制腫瘤浸潤(rùn)T細(xì)胞功能的細(xì)胞和分子機(jī)制，20ZR1448900，2020/07-2023/06，主持

2. 國(guó)家重點(diǎn)研發(fā)計(jì)劃課題，2019YFA0111003，利用新型CAR-T治療復(fù)發(fā)難治T細(xì)胞淋巴瘤的臨床研究，2019/11-2023/12，主要參與人

3. 國(guó)家自然科學(xué)基金面上項(xiàng)目，81671590，CD8⁺CXCR3⁺ T細(xì)胞調(diào)控Tfh細(xì)胞功能的分子機(jī)制及其在系統(tǒng)性紅斑狼瘡中作用的機(jī)制研究，2017/01-2020/20，主持

4. 科技部973課題，2014CB541803，遺傳變異調(diào)控AS自身免疫紊亂的分子機(jī)制研究，2014/01-2018/12，主要參與人

5. 國(guó)家自然科學(xué)基金面上項(xiàng)目，81273307，阻斷IL-7/IL-7R信號(hào)通路治療類風(fēng)關(guān)細(xì)胞與分子機(jī)制研究，2013/1-2016/12，主持

6. 國(guó)家自然科學(xué)基金面上項(xiàng)目，81072470，TNFa下調(diào)類風(fēng)關(guān)Treg細(xì)胞磷酸化Foxp3表達(dá)及促進(jìn)Th17細(xì)胞分化機(jī)制研究，2011/1-2013/12，主持

7. 國(guó)家自然科學(xué)基金面上項(xiàng)目，30872304，Qa-1限制性調(diào)節(jié)性CD8⁺ T細(xì)胞系建立、特性及效應(yīng)機(jī)制研究，2009/1-2011/12，主持

1. Jiang Y^#, Yuan Y^#*, Chen M, Li S, Bai J, Zhang Y, Sun Y, Wang G, Xu H, Wang Z, Zheng Y*, Nie H*. PRMT5 disruption drives antitumor immunity in cervical cancer by reprogramming T cell-mediated response and regulating PD-L1 expression. Theranostics. 2021, 11(18): 9162-9176.

2.  Xu H^#, Cai L^#, Li Z^#, Zhang L, Wang G, Xie R, Jiang Y, Yuan Y, Nie H*. Dual effect of IL-7/IL-7R signalling on the osteoimmunological system: a potential therapeutic target for rheumatoid arthritis. Immunology. 2021, 164(1): 161-172.

3.  Wang Z^#, Li Z^#, Wang G, Sun Y, Yuan Y*, Nie H*. Salubrinal alleviates collagen-induced arthritis through promoting P65 degradation in osteoclastogenesis. Int J Mol Sci. 2021, 22(7): 3501.

4.  Yuan Y, Nie H*. Protein arginine methyltransferase 5: a potential cancer therapeutic target. Cell Oncol (Dordr). 2021, 44(1): 33-44.

5.  Duan W^#, Sun Y^#, Wu M^#, Zhang Z, Zhang T, Wang H, Li F, Yang L, Xu Y, Liu ZJ, Hua T*, Nie H*, Cheng J*. Carbon-silicon switch led to the discovery of novel synthetic cannabinoids with therapeutic effects in a mouse model of multiple sclerosis. Eur J Med Chem. 2021, 226: 113878.

6.  Zheng Y^#*, Lu Y^#, Huang X, Han L, Chen Z, Zhou B, Ma Y, Xie G, Yang J, Bian B, Li L, Nie H, Pan X*, Shen L*. BACH2 regulates the function of human CD4⁺ CD45RA^- Foxp3^{l o} cytokine-secreting T cells and promotes B-cell response in systemic lupus erythematosus. Eur J Immunol. 2020, 50(3): 426-438.

7.  Yang L^#, Chen S^#, Zhao Q^#, Sun Y*, Nie H*. The Critical role of Bach2 in shaping the balance between CD4⁺ T cell subsets in immune-mediated diseases. Mediators Inflamm. 2019, 2609737.

8.  Xu H^#, Cai L^#, Zhang L, Wang G, Xie R, Jiang Y, Yuan Y*, Nie H*. Paeoniflorin ameliorates collagen-induced arthritis via suppressing nuclear factor-κB signalling pathway in osteoclast differentiation. Immunology. 2018, 154: 593-603.

9.  Wei J^#, Wu J^#, Xu W^#, Nie H, Zhou R, Wang R, Liu Y, Tang G*, Wu J*. Salvanic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1a signaling pathway. Cell Death Dis. 2018, 9(6): 599.

10. Zhang H^#, Qi Y^#, Yuan Y^#, Cai L, Xu H, Zhang L, Su B, Nie H*. Paeoniflorin ameliorates experimental autoimmune encephalomyelitis via inhibition of dendritic cell function and Th17 cell differentiation. Sci Rep. 2017, 7: 41887.

11. Cai L^#, Xu H^#, Zhang H, Zhang L, Wang G, Nie H*. Blockade of IL-7Rα alleviates collagen-induced arthritis via inhibiting Th1 cell differentiation and CD4⁺ T cell migration. Mol Immunol. 2016, 79: 83-91.

12. Zheng Y^#, Sun L^#, Jiang T, Zhang D, He D*, Nie H*. TNFa promotes Th17 cell differentiation through IL-6 and IL-1b produced by monocytes in rheumatoid arthritis. J Immunol Res. 2014, 385352.

13. Sun Q^#, Zheng Y^#, Zhang Y^#, Hu X, Wang Y, Zhang S, Zhang D, Nie H*. Novel immunoregulatory properties of EGCG on reducing inflammation in EAE. Front Biosci (Landmark). 2013, 18: 332-342.

14. Nie H^#, Zheng Y^#, Li R^#, Guo T.B, He D, Fang L, Liu X, Xiao L, Chen X, Wan B, Chin Y.E, Zhang J*. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-a in rheumatoid arthritis. Nat Med. 2013, 19(3): 322-328.

15. Yin Q, Liu C, Wu Y, Wu S, Wang Y, Zhang X, Hu X, Pu J, Lu Y, Zhou H, Wang H, Nie H, Sun H*, Chen G*. Preventive and therapeutic effects of adenanthin on experimental autoimmune encephalomyelitis by inhibiting NF-κB signaling. J Immunol. 2013, 191(5):2115-2125.