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師資隊(duì)伍
王鋒
  作者:  2018-12-31

基本信息 >>>

                                                                                                                                            
  王鋒
  免疫細(xì)胞信號(hào)與代謝研究組
  電話:63846590-776798
  郵箱:[email protected]

研究方向>>>

本實(shí)驗(yàn)室主要研究T淋巴細(xì)胞的免疫識(shí)別,,信號(hào)轉(zhuǎn)導(dǎo)和代謝調(diào)節(jié)機(jī)制,,以及其在腫瘤,、感染和自身免疫疾病中的作用,。我們將應(yīng)用免疫學(xué),、分子細(xì)胞生物學(xué),、生物物理和生物化學(xué)等多種技術(shù)手段對(duì)以下三個(gè)方向進(jìn)行探索:(1)天然代謝產(chǎn)物調(diào)控T細(xì)胞識(shí)別和信號(hào)的分子機(jī)理和生理功能,;(2)T細(xì)胞信號(hào)和免疫受體組庫(kù)在腫瘤和感染免疫中的作用,;(3)T細(xì)胞免疫檢驗(yàn)點(diǎn)抑制劑引起的抗腫瘤和自身免疫反應(yīng)機(jī)制,。

個(gè)人簡(jiǎn)歷 >>>

王鋒,研究員,,博士生導(dǎo)師,,上海交通大學(xué)醫(yī)學(xué)院/上海市免疫學(xué)研究所課題組長(zhǎng)(PI)。2005年本科畢業(yè)于北京師范大學(xué)生命科學(xué)學(xué)院,,2010年獲得北京師范大學(xué)和北京生命科學(xué)研究所聯(lián)合培養(yǎng)博士學(xué)位,。2010-2016年在斯坦福大學(xué)師從T細(xì)胞受體發(fā)現(xiàn)者,美國(guó)國(guó)家科學(xué)院院士Mark M. Davis教授進(jìn)行博士后訓(xùn)練,。長(zhǎng)期致力于T細(xì)胞抗原識(shí)別和信號(hào)轉(zhuǎn)導(dǎo)的代謝調(diào)節(jié)機(jī)制研究,。以通訊/第一作者在Nature Immunology2016, PNAS20182020, BMC Biology2020),,Cell Discovery2021, Theranostics2021),,EMBO Journal2022)等國(guó)際知名學(xué)術(shù)期刊發(fā)表系列研究論文。入選國(guó)家高層次青年拔尖人才,上海高校特聘教授,,上海市高層次青年人才和浦江人才計(jì)劃,。近五年帶領(lǐng)團(tuán)隊(duì)承擔(dān)包括國(guó)家重點(diǎn)研發(fā)計(jì)劃和國(guó)家自然科學(xué)基金在內(nèi)的國(guó)家級(jí)課題9項(xiàng),上海市科委和上海市衛(wèi)健委資助的省部級(jí)項(xiàng)目4項(xiàng),。

科研項(xiàng)目 >>>

1 免疫檢驗(yàn)點(diǎn)阻斷條件下共生菌對(duì)Treg細(xì)胞功能和腸道炎癥反應(yīng)的調(diào)節(jié)機(jī)制 國(guó)家自然科學(xué)基金面上項(xiàng)目,2021-01~2024-12,55萬(wàn)元,課題負(fù)責(zé)人

2 新型冠狀病毒抗原T細(xì)胞免疫識(shí)別及受體組庫(kù)動(dòng)態(tài)研究 上海市科委國(guó)際合作項(xiàng)目 2020-10~2023-09,45萬(wàn)元,課題負(fù)責(zé)人

3 重要病原體疫苗的人工合成 國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目 2019-01~2024-12,111.3萬(wàn)元,課題骨干

4 免疫識(shí)別和信號(hào)的代謝調(diào)節(jié)機(jī)制 上海市青年拔尖人才開發(fā)項(xiàng)目 2019-01~2021-12,15萬(wàn)元,課題負(fù)責(zé)人

5 T細(xì)胞受體識(shí)別及抗腫瘤免疫機(jī)制 上海市科委基礎(chǔ)研究項(xiàng)目 2018-07~2021-06,40萬(wàn)元,課題負(fù)責(zé)人

6 代謝產(chǎn)物的免疫調(diào)節(jié)機(jī)制 海外高層次人才 2018-01~2020-12,100萬(wàn)元,課題負(fù)責(zé)人

7 硫酸膽固醇在實(shí)驗(yàn)性自身免疫性腦脊髓炎中的作用機(jī)制 國(guó)家自然科學(xué)基金面上項(xiàng)目,2018-01-~2021-12,56萬(wàn)元,課題負(fù)責(zé)人

8 膽固醇代謝的免疫調(diào)節(jié)作用 上海市浦江人才計(jì)劃 2017-07~2019-06,20萬(wàn)元,課題負(fù)責(zé)人

9 膽固醇代謝的免疫調(diào)節(jié)作用 上海交通大學(xué)青年教師啟動(dòng)計(jì)劃 2017-01~2019-01,20萬(wàn)元,課題負(fù)責(zé)人

10 基于代謝產(chǎn)物的免疫調(diào)節(jié)機(jī)制研究 上海交通大學(xué)醫(yī)學(xué)院高峰高原計(jì)劃啟動(dòng)經(jīng)費(fèi),2016-11~2022-10,300萬(wàn)元,課題負(fù)責(zé)人

論文與專著 >>>

1. Sun S, Luo L, Liang W, Yin Q, Guo J, Rush MA, Lv Z, Liang Q, Fischbach AM, Sonnenburg LJ, Dodd D, Davis MM, Wang F#. Bifidobacterium alters the gut microbiota and modulates the functional metabolism of Treg cells in the context of CTLA-4 blockade. PNAS, 2020, DOI:https://doi.org/10.1073/pnas.1921223117.

2. Li Y, Wang Y, Yao Y, Griffiths BB, Feng L, Tao T, Wang F, Xu B, Stary CM, Zhao H. Systematic Study of the Immune Components after Ischemic Stroke Using CyTOF Techniques, Journal of Immunology Research, 2020, DOI:https://doi.org/10.1155/2020/9132410.

3. Zeng J, Dong S, Luo Z, Xie X, Fu B, Li P, Liu C, Yang X, Chen Y, Wang X, Liu Z, Wu J, Yan Y, Wang F, Chen J, Zhang J, Long G, Goldman SA, Li S, Zhao Z, Liang Q. The Zika Virus Capsid Disrupts Corticogenesis by Suppressing Dicer Activity and miRNA Biogenesis. Cell Stem Cell, 2020, DOI:https://doi.org/10.1016/j.stem.2020.07.012.

4. Zhang S, Liang W, Luo L, Sun S, Wang F#. The role of T cell trafficking in CTLA-4-blockade induced gut immunopathology. BMC Biology, 2020, 18:29. doi.org/10.1186/s12915-020-00765-9.

5. Leng Q#, Tarbe M, Long Q, Wang F#. Preexisting heterologous T cell immunity and neoantigen immunogenicity. Clinical & Translational Immunology, 2020, 9:3. doi: 10.1002/cti2.1111.

6. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B#, Liu J#, Zou Q#. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metabolism, 2019, 30(2):290-302.

7. Wang Y, Jin H, Wang W, Wang F#, Zhao H#. Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice. Journal of Neuroinflammation, 2019, 16(1):77. doi: 10.1186/s12974-019-1465-9.

8. Wang F#, Yin Q, Chen L, and Davis MM#. Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade. PNAS, 2018, 115(1): 157-161.

9. Wang F, Beck-García K, Zorzin C, Schamel WW, and Davis MM. Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol. Nature Immunology, 2016, 17(7): 844-850.

10. Zhu P, Wang Y, Oin N, Wang F, Wang J, Deng XW, Zhu D. An Arabidopsis small nucleolar RNA monitors the efficient pre-rRNA processing during ribosome biogenesis. PNAS, 2016, 113(42): 11967-11972.

11. Roh KH, Lillemeier BF, Wang F, and Davis MM. The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck. PNAS, 2015, 112(13): 1604-1613.

12. Wang F, Deng XW. Plant ubiquitin-proteasome pathway and its role in gibberellin signaling. Cell Research, 2011, 21(9): 1286-1294.

13. Wang F, Zhu D, Huang X, Li S, Gong Y, Yao Q, Fu X, Fan LM, and Deng XW. Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system. Plant Cell, 2009, 21(8): 2378-2390.

14. Liu Y, Wang F, Zhang H, He H, Ma L, and Deng XW. Functional characterization of the Arabidopsis ubiquitin-specific protease gene family reveals specific role and redundancy of individual members in development. Plant Journal, 2008, 55(5): 844-856.

15. Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F, Chen L, Yu L, Iglesias-Pedraz JM, Kircher S, Schafer E, Fu X, Fan LM, and Deng XW. Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature, 2008, 451(7177): 475-479.