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  劉智多

  免疫微環(huán)境課題組

  電話：021-63846590-776749

  郵箱：[email protected]

1.闡明巨噬細(xì)胞如何通過調(diào)控基質(zhì)細(xì)胞的活化來影響局部的免疫反應(yīng);

2.揭示組織中調(diào)控巨噬細(xì)胞炎性基因表達(dá)的新機制,，這些局部的炎癥反應(yīng)在介導(dǎo)組織損傷及腫瘤發(fā)生方面至關(guān)重要,。

期待我們的工作為理解免疫反應(yīng)的精細(xì)調(diào)控以及相應(yīng)的免疫治療開發(fā)提供新的視角。

1997-2001 武漢大學(xué) 學(xué)士

2001-2009 中國科學(xué)院上海生命科學(xué)研究院 博士

2009-2010 中國科學(xué)院上海生命科學(xué)研究院 研究助理

2010-2016 美國國立健康研究院(National Institutes of Health) 博士后

2016-至今 上海交通大學(xué)醫(yī)學(xué)院上海市免疫學(xué)研究所 研究員

1. 科技部重點研發(fā)項目,， 240萬元,， 2021-12至2024-11，在研,，參與

2. 國家自然科學(xué)基金委面上項目,，58萬元,，2021-01至2024-12，主持

3. 國家自然科學(xué)基金委面上項目,，60萬元,，2019-01至2022-12，主持

4. 上海市“浦江人才計劃” ,，20萬元,，2017-07至2019-06，主持

5. 上海市自然基金項目,，20萬元,，2017-05至2020-04，主持

1. Liu Z, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN. Immune homeostasis enforced by co-localized effector and regulatory T cells. Nature. 2015, 528(7581):225-30. (First author)

2. Yu X^#, Teng XL^#, Wang F^#, Zheng Y^#, Qu G, Zhou Y, Hu Z, Wu Z, Chang Y, Chen L, Li HB, Su B, Lu L*, Liu Z*, Sun SC*, Zou Q*. Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome. J Exp Med. 2018, 215(9):2463-2476. (Co-correspondence)

3. Wu N^#, Sun H^#, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B.MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature, 2021 Apr;592(7855): 606-610.

4. Guan C, Huang X, Yue J, Xiang H, Shaheen S, Jiang Z, Tao Y, Tu J, Liu Z, Yao Y, Yang W, Hou Z, Liu J, Yang XD, Zou Q, Su B, Liu Z, Ni J*, Cheng J*, Wu X*. SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation. Theranostics. 2021 Feb 15; 11(8):3981-3995.

5. Jin F^#, Li J^#, Zhang YB^#, Liu X^#, Cai M, Liu M, Li M, Ma C, Yue R, Zhu Y, Lai R, Wang Z, Ji X, Wei H, Dong J, Liu Z, Wang Y*, Sun Y*, Wang X*. A functional motif of long noncoding RNA Nron against osteoporosis. Nat Commun. 2021 Jun 3; 12(1):3319.

6. Yang XD^#*, Li W, Zhang S, Wu D, Jiang X, Tan R, Niu X, Wang Q, Wu X, Liu Z, Chen LF, Qin J, Su B*. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J. 2020, 39(2):e102201.

7. Liu Z, Gu Y, Chakarov S, Bleriot C, Kwok I, Chen X, Shin A, Huang W, Dress RJ, Dutertre CA, Schlitzer A, Chen J, Ng LG, Wang H, Liu Z, Su B*, Ginhoux F*. Fate Mapping via Ms4a3-Expression History Traces Monocyte-Derived Cells. Cell. 2019, 178(6):1509-1525.e19.

8. Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O. A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System. Immunity. 2017 Apr 18;46(4):609-620.

9. Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN. Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells. J Immunol. 2017 Jan 15;198(2):895-907.

10.Lo B, Zhang K, Lu W, Zheng L, Zhang Q, Kanellopoulou C, Zhang Y, Liu Z, Fritz JM, Marsh R, Husami A, Kissell D, Nortman S, Chaturvedi V, Haines H, Young LR, Mo J, Filipovich AH, Bleesing JJ, Mustillo P, Stephens M, Rueda CM, Chougnet CA, Hoebe K, McElwee J, Hughes JD, Karakoc-Aydiner E, Matthews HF, Price S, Su HC, Rao VK, Lenardo MJ, Jordan MB. AUTOIMMUNE DISEASE. Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy. Science. 2015 Jul 24;349(6246):436-40.

11.Li Z, Zhang Y, Liu Z, Wu X, Zheng Y, Tao Z, Mao K, Wang J, Lin G, Tian L, Ji Y, Qin M, Sun S, Zhu X, Sun B. ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat. Immunol. 2011 Feb;12(2):178-85.