1. Su B, Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. JNK mediates signal integration during costimulation of T lymphocytes. Cell 77:727-736, 1994. 2. Yang J, Boerm M, McCarty M, Bucana C, Fidler J, Zhuang Y, and Su B. Essential role of MEKK3 in early embryonic cardiovascular development. Nature Genetics, 24(3):309-13, 2000. 3. Yang J, Lin Y, Guo Z, Borem M, Huang H, Liao, Chen Z, Liu ZG* and Su B*. Essential role of MEKK3 in TNF-induced NF-kB activation. Nat Immunol. 2001 Jul;2(7):620-4. 4. Huang Q, Yang J, Lin Y, Walker C, Cheng J, Liu ZG, Su B. Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3.Nat Immunol. 2004 Jan;5(1):98-103. 5. Zhang D, Facchinetti V, Wang X, Huang Q, Qin J, Su B. Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor- and stress-pathways. EMBO J. 2006 Jan 11;25(1):97-107. 6. Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J*, Su B*. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 127(1):125-37. 2006. 7. Facchinetti V*, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B*, Jacinto E*. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J. 2008 Jul 23;27(14):1932-43. 8. Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B. Sin1 suppresses rag1/2 and il7r gene expression through Akt2 in B cells. Mol. Cell. 2010. Aug 13;39(3):433-43. 9. Xing Chang, Fang Liu, Xiaofang Wang, and Su B. MEKK2 and MEKK3 regulate TGF-b-mediated helper T cell differentiation. Immunity. 34: 201-212, 2011. 10.Zhang F, Lazorchak AS, Liu D, Chen F*, Su B*. Inhibition of the mTORC2 and chaperone pathways to treat leukemia. Blood. 2012 Jun 21;119(25):6080-8. 11.Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ*, Su B.* Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun. 2015 Aug 3; 6:7937. 12.Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B* and Wu ZB*. Selective mTORC1 inhibition by lncRNA H19 via disruption of the 4E-BP1 and Raptor interaction in pituitary tumors . Nature Communications,2018, 9:4624. 13.Li M, Lazorchak AS, Ouyang X, Zhang H, Liu H, Arojo OA, Yan L, Jin J, Han Y, Qu G, Fu Y, Xu X, Liu X, Zhang W, Yang Z, Ruan C, Wang Q, Liu D, Huang C, Lu L, Jiang S, Li F*, Su B*. Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation. Cell Mol Immunol. 2019 Sep;16(9):757-769. 14.Ouyang X, Han Y, Qu G, Li M, Wu N, Liu H, Arojo O, Sun H, Liu X, Liu D, Chen L, Zou Q*, Su B*. Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2. J Mol Cell Biol. 2019 Feb 1;11(2):93-106. 15.Liu Z, Gu Y, Chakarov S, Bleriot C, Kwok I, Chen X, Shin A, Huang W, Dress RJ, Dutertre CA, Schlitzer A, Chen J, Ng LG, Wang H, Liu Z, Su B*, Ginhoux F*. Fate mapping via Ms4a3 expression history traces monocyte-derived cells. Cell. 2019 Sep 5;178(6):1509-1525. 16.Yang XD*, Li W, Zhang S, Wu D, Jiang X, Tan R, Niu X, Wang Q, Wu X, Liu Z, Chen LF, Qin J, Su B*. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome. EMBO J. 2020 Jan 15;39(2):e102201 17.Wu N, Chen D, Sun H, Tan J, Zhang Y, Zhang T, Han Y, Liu H, Ouyang X, Yang XD, Niu X, Zhong J, Wang Z*, Su B*, MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis. SCIENCE CHINA Life Sciences.2020 Jul 28.doi: 10.1007/s11427-020-1720-9. 18.Qi J, Crinier A, Escalière B, Ye Y, Wang Z, Zhang T, Batista L, Liu H, Hong L, Wu N, Zhang M, Chen L, Liu Y, Shen L, Narni-Mancinelli E, Vivier E, Su B*. Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression. Cell Rep Med. 2021 Jul 27;2(8):100353. 19.Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature. 2021 Apr;592(7855):606-610. 20. Qi J, Sun H, Zhang Y, Wang Z, Xun Z, Li Z, Ding X, Bao R, Hong L, Jia W, Fang F, Liu H, Chen L, Zhong J, Zou D, Liu L, Han L, Ginhoux F, Liu Y, Ye Y, Su B*. Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer. Nat Commun. 2022 Apr 1;13(1):1742. |
