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李乾,，博士，Qian Li,，Ph.D.

嗅覺(jué)系統(tǒng)發(fā)育及相關(guān)疾病研究組

Laboratory Of Olfactory Physiology and Pathology (LOOP)

Shanghai Jiao Tong University School of Medicine

電話（Tel）：63846590-776985

郵箱（Email）：[email protected]

李乾研究員,，博士生導(dǎo)師。2004年本科畢業(yè)于中國(guó)科學(xué)技術(shù)大學(xué),，2009年博士畢業(yè)于中國(guó)科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所,，2010-2016年在美國(guó)哈佛大學(xué)從事博士后工作，并于2016年加入上海交通大學(xué)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院,，擔(dān)任“嗅覺(jué)系統(tǒng)發(fā)育及相關(guān)疾病”研究員組組長(zhǎng),。主要工作以通訊或第一作者（包含共同）發(fā)表于Nature、Cell,、Nature Communications,、Molecular Biology and Evolution,、Molecular Systems Biology、Current Biology,、PNAS,、eLife和Cell Reports等國(guó)際期刊。

一,、在研

1. 國(guó)家自然科學(xué)基金面上項(xiàng)目,，批準(zhǔn)號(hào)：32371042，《Tbr1調(diào)控特異嗅覺(jué)神經(jīng)元亞群發(fā)育的機(jī)制研究》,，2024/01-2027/12,，在研，50萬(wàn)元,，主持,。

2. 上海市科委科技創(chuàng)新行動(dòng)計(jì)劃原創(chuàng)探索項(xiàng)目，批準(zhǔn)號(hào)：23ZR1480000,，《特異嗅覺(jué)神經(jīng)元亞群的發(fā)育機(jī)制研究》,，2023/04-2026/03，50萬(wàn)元,，在研,，主持。

3. 國(guó)家自然科學(xué)基金優(yōu)秀青年項(xiàng)目,，批準(zhǔn)號(hào)：32122038,，《嗅覺(jué)神經(jīng)元亞群命運(yùn)決定》，2022/01-2024/12,，200萬(wàn)元,，在研，主持,。

4. 國(guó)家自然科學(xué)基金面上項(xiàng)目，批準(zhǔn)號(hào)：31970933,，《ATF5調(diào)控嗅覺(jué)受體基因選擇的分子機(jī)制研究》,，2020/01-2023/12，58萬(wàn)元,，在研,，主持。

5. 科技部科技創(chuàng)新2030—“腦科學(xué)與類腦研究”重大項(xiàng)目2021年度項(xiàng)目,，批準(zhǔn)號(hào)：2021ZD203100,，《感知覺(jué)與情緒相互作用的神經(jīng)環(huán)路機(jī)制》，2021/12-2026/11,，3500萬(wàn)元,，在研,，子課題負(fù)責(zé)人。

6. 上海市科委科技創(chuàng)新行動(dòng)計(jì)劃基礎(chǔ)研究領(lǐng)域項(xiàng)目,，批準(zhǔn)號(hào)：21JC1404500,，《嗅覺(jué)干細(xì)胞分化成嗅覺(jué)神經(jīng)元亞群的機(jī)制研究》，2021/10-2024/09,，100萬(wàn)元,，在研，主持,。

7. 上海市教委/教育發(fā)展基金會(huì)“曙光計(jì)劃”,，批準(zhǔn)號(hào)：21SG16，2022/01-2024/12,，15萬(wàn)元,，在研，主持,。

8. 上海交通大學(xué)醫(yī)學(xué)院高峰高原計(jì)劃啟動(dòng)經(jīng)費(fèi),，200萬(wàn)元，在研,，主持,。

二、結(jié)題

1. 國(guó)家自然科學(xué)基金面上項(xiàng)目,，批準(zhǔn)號(hào)：31771154,，《痕量胺相關(guān)受體新型嗅覺(jué)子系統(tǒng)的功能和發(fā)育機(jī)制》，2018/01-2021/12,，63萬(wàn)元,，結(jié)題，主持,。

2. 上海市高層次人才,，批準(zhǔn)號(hào)：QD2018017，2019/01-2021/12,，60萬(wàn)元,，結(jié)題，主持,。

3. 上海市科委基礎(chǔ)研究重點(diǎn)項(xiàng)目,，批準(zhǔn)號(hào)：18JC1420302，《感知認(rèn)知神經(jīng)網(wǎng)絡(luò)的功能及其障礙機(jī)制》,，2018/12-2021/11,，938萬(wàn)元，結(jié)題,，研究骨干,。

4. 上海市浦江人才計(jì)劃A類,，批準(zhǔn)號(hào)：17PJ1405400，《痕量胺相關(guān)受體嗅覺(jué)神經(jīng)元發(fā)育的分子機(jī)制》,，2017/07-2019/06,，20萬(wàn)元，結(jié)題,，主持,。

5. 上海交通大學(xué)新進(jìn)青年教師啟動(dòng)計(jì)劃，20萬(wàn)元,，結(jié)題,，主持。

代表性論文：（^#co-first author, *corresponding/co-corresponding author）

（一） 通訊/共同通訊作者

1. Shang, Pan^#; Rong, Naikang^#; Jiang, Jing-Jing^#; Cheng, Jie^#; Zhang, Ming-Hui^#; Kang, Dongwei^#; Qi, Lei^#; Guo, Lulu; Yang, Gong-Ming; Liu, Qun; Zhou, Zhenzhen; Li, Xiao-Bing; Zhu, Kong-Kai; Meng, Qing-Biao; Han, Xiang; Yan, Wenqi; Kong, Yalei; Yang, Lejin; Wang, Xiaohui; Lei, Dapeng; Feng, Xin; Liu, Xinyong; Yu, Xiao; Wang, Yue*; Li, Qian*; Shao, Zhen-Hua*; Yang, Fan*; Sun, Jin-Peng*. “Structural and signaling mechanisms of TAAR1 enabled preferential agonist design”. Cell, 2023, 186(24):5347-5362.e24.

2. Guo, Lulu^#; Cheng, Jie^#; Lian, Shuo^#; Liu, Qun^#; Lu, Yan^#; Zheng, Yuan^#; Zhu, Kongkai^#; Zhang, Minghui;Kong, Yalei; Zhang, Chao; Rong, Naikang; Zhuang, Yuming; Fang, Guoxing; Jiang, Jingjing; Zhang, Tianyao;Han, Xiang; Liu, Zili; Xia, Ming; Liu, Shangming; Zhang, Lei; Liberles, Stephen D; Yu, Xiao; Xu, Yunfei*; Yang, Fan*; Li, Qian*; Sun, Jin-Peng*. “Structural basis of amine odorant perception by a mammal olfactory receptor”. Nature, 2023, 618(7963):193.

3. Guo, Lingna^#; Dai, Wenxuan^#; Xu, Zhengrong^#; Liang, Qiaoyi; Miller, Eliot T; Li, Shengju; Gao, Xia; Baldwin, Maude W; Chai, Renjie*; Li, Qian*. “Evolution of brain-expressed biogenic amine receptors into olfactory trace amine-associated receptors”. Molecular Biology and Evolution, 2022, 39(3):msac006.

4. Zhou, Haiqian^#; Zhuang, Liujing^#; Bao, Hongqiang^#; Li, Shengju; Dai, Fengyan; Wang, Ping; Li, Qian*; Yin, Dongmin*. “Olfactory regulation by dopamine and DRD2 receptor in the nose”. PNAS, 2022, 119(11):e2118570119.

5. Song, Chunxue; Zeng, Xianting; Zeng, Wanxin; Liu, Rong; Tong, Xiajing*; Li, Qian*. “A WDR47 homolog facilitates ciliogenesis by modulating intraflagellar transport”. Journal of Cell Science, 2022, 135(24):jcs260303.

6. Zhang, Qianwen^#; Ding, Yu^#; Feng, Biyun; Tang, Yijun; Chen, Yao; Wang, Yirou; Chang, Guoying; Liu, Shijian; Wang, Jian; Li, Qian*; Fu, Lijun*; Wang, Xiumin*. “Molecular and phenotypic expansion of Alstr?m syndrome in Chinese patients”. Frontiers in Genetics, 2022, 13:808919.

7. Xu, ZhengRong^#; Guo, LingNa^#; Qian, XiaoYun^#; Yu, ChenJie^#; Li, ShengJu; Zhu, ChengWen; Ma, XiaoFeng; Li, Hui; Zhu, GuangJie; Zhou, Han; Dai, WenXuan*; Li, Qian*; Gao, Xia*. “Two entry tunnels in mouse TAAR9 suggest the possibility of multi-entry tunnels in olfactory receptors”. Scientific Reports, 2022, 12(1):2691.

8. Fei, Aimei^#; Wu, Wanqing^#; Tan, Longzhi^#; Tang, Cheng^#; Xu, Zhengrong; Huo, Xiaona; Bao, Hongqiang; Johnson, Mark; Hartmann, Griffin; Talay, Mustafa; Yang, Cheng; Riegler, Clemens; Joseph, Kristian; Engert, Florian; Xie, X Sunney; Barnea, Gilad; Liberles, Stephen D; Yang, Hui; Li, Qian*. “Coordination of two enhancers drives expression of olfactory trace amine-associated receptors”. Nature Communications, 2021, 12(1): 3798.

9. Qian, Kang-Ying; Zeng, Wan-Xin; Hao, Yue; Zeng, Xian-Ting; Liu, Haowen; Li, Lei; Chen, Lili; Tian, Fu-Min; Chang, Cindy; Hall, Qi; Song, Chun-Xue; Gao, Shangbang; Hu, Zhi-Tao; Kaplan, Josh M; Li, Qian*; Tong, Xia-Jing*. “Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner”. eLife, 2021, 10: e67170.

10. Jia, Liang^#; Li, Shengju^#; Dai, Wenxuan; Guo, Lingna; Xu, Zhengrong; Scott, Anne M; Zhang, Zhe; Ren, Jianfeng; Zhang, Qinghua; Dexheimer, Thomas S; Chung-Davidson, Yu-Wen; Neubig, Richard R*; Li, Qian*; Li, Weiming*. “Convergent olfactory trace amine-associated receptors detect biogenic polyamines with distinct motifs via a conserved binding site”. Journal of Biological Chemistry, 2021, 297(5): 101268.

11. Gan, Linhua^#; Sun, Jingjing^#; Yang, Shuo; Zhang, Xiaocui; Chen, Wu; Sun, Yiyu; Wu, Xiaohua; Cheng, Cheng; Yuan, Jing; Li, Anan; Corbett, Mark A.; Dixon, Mathew P.; Thomas, Tim; Voss, Anne K.; Gecz, Jozef; Wang, Guang-Zhong; Bonni, Azad; Li, Qian*; Huang, Ju*. “Chromatin-binding protein PHF6 regulates activity-dependent transcriptional networks to promote hunger response”. Cell Reports, 2020, 30(11): 3717-3728.e6.

12. Xu, Zhengrong; Li, Qian*. “TAAR agonists”. Cellular and Molecular Neurobiology, 2020, 40(2): 257-272.

（二） 第一/共同第一作者

1. Tan, Longzhi^#; Li, Qian^#; Xie, X Sunney*. “Olfactory sensory neurons transiently express multiple olfactory receptors during development”. Molecular Systems Biology, 2015, 11(12): 844. (Highlighted in Nature Chemical Biology)

2. Li, Qian; Tachie, Baffour Yaw; Liu, Zhikai; Baldwin, Maude W; Kruse, Andrew C; Liberles, Stephen D*. “Non-classical amine recognition evolved in a large clade of olfactory receptors”. eLife, 2015, 4: e10441.

3. Li, Qian; Liberles, Stephen D*. “Aversion and attraction through olfaction”. Current Biology, 2015, 25(3): 120-129.

4. Li, Qian; Korzan, Wayne J; Ferrero, David M; Chang, Rui B; Roy, Dheeraj S; Buchi, Melanie; Lemon, Jamie K; Kaur, Angeldeep W; Stowers, Lisa; Fendt, Markus; Liberles, Stephen D*. “Synchronous evolution of an odor biosynthesis pathway and behavioral response”. Current Biology, 2013, 23(1): 11-20. (Commented in Current Biology)

5. Li, Qian; Su, Yuan Yuan; Wang, Hao; Li, Lei; Wang, Qiong; Bao, Lan*. “Transmembrane segments prevent surface expression of sodium channel Na(v)1.8 and promote calnexin-dependent channel degradation”. Journal of Biological Chemistry, 2010, 285(43): 32977-32987.

6. Zhang, Zhen Ning^#; Li, Qian^#; Liu, Chao; Wang, Hai Bo; Wang, Qiong; Bao, Lan*. “The voltage-gated Na(+) channel Na(v)1.8 contains an ER-retention/retrieval signal antagonized by the beta 3 subunit”. Journal of Cell Science, 2008, 121(19): 3243-3252.

（三） 專著

1. Li, Qian; Liberles, Stephen D*. “Odor sensing by trace amine-associated receptors”. Book Chemosensory transduction: the detection of odors, tastes, and other chemostimuli, Chapter 4, 2016.

2. Li, Qian*. “Deorphanization of olfactory trace amine-associated receptors”. Book Olfactory receptors: methods and protocols, Chapter 2, 2018.