曾凡一 教授
組織胚胎學(xué)與遺傳發(fā)育學(xué)系
電話：86-21-62790545
Email: [email protected]
研究方向：
醫(yī)學(xué)遺傳學(xué)和發(fā)育生物學(xué)，尤其是干細(xì)胞和哺乳動(dòng)物胚胎工程等交叉領(lǐng)域的研究
個(gè)人簡(jiǎn)歷
美國(guó)賓夕法尼亞大學(xué)臨床醫(yī)學(xué)和發(fā)育生物學(xué)醫(yī)學(xué)/理學(xué)雙博士，中國(guó)醫(yī)學(xué)科學(xué)院學(xué)術(shù)咨詢委員會(huì)學(xué)部委員，研究員（二級(jí)），博導(dǎo)。國(guó)家重大科學(xué)研究計(jì)劃項(xiàng)目（“973”項(xiàng)目）首席科學(xué)家，“重大新藥創(chuàng)制”科技重大專項(xiàng)首席科學(xué)家，長(zhǎng)江學(xué)者特聘教授，國(guó)家杰青獲得者，首批出生缺陷防控咨詢師（高級(jí)）。現(xiàn)任上海交通大學(xué)特聘教授、上海交通大學(xué)醫(yī)學(xué)遺傳研究所所長(zhǎng)。從事醫(yī)學(xué)遺傳學(xué)、發(fā)育生物學(xué)等交叉領(lǐng)域研究，承擔(dān)國(guó)家級(jí)、省部級(jí)等重大項(xiàng)目十余項(xiàng)，在國(guó)際著名期刊《Nature》、《PNAS》等發(fā)表SCI論文100余篇。研究成果被美國(guó)《時(shí)代》周刊評(píng)為“全球十大醫(yī)學(xué)突破”之一，多次入選“中國(guó)基礎(chǔ)研究十大新聞”。獲國(guó)家自然科學(xué)獎(jiǎng)二等獎(jiǎng)、教育部自然科學(xué)獎(jiǎng)一等獎(jiǎng)、首屆第三世界女青年科學(xué)家獎(jiǎng)、談家楨生命科學(xué)獎(jiǎng)創(chuàng)新獎(jiǎng)等。擔(dān)任國(guó)際干細(xì)胞組織（ISCF）秘書長(zhǎng)及倫理委員會(huì)中國(guó)代表、中國(guó)遺傳學(xué)會(huì)常務(wù)理事及人類與醫(yī)學(xué)遺傳專委會(huì)主委、中國(guó)細(xì)胞生物學(xué)學(xué)會(huì)干細(xì)胞生物學(xué)分會(huì)副會(huì)長(zhǎng)、中華醫(yī)學(xué)會(huì)醫(yī)學(xué)遺傳學(xué)分會(huì)常委兼秘書長(zhǎng)等學(xué)術(shù)職務(wù)。
科研項(xiàng)目
1) 2024.12-2027.11國(guó)家重點(diǎn)研發(fā)計(jì)劃“生育健康及婦女兒童健康保障”重點(diǎn)專項(xiàng)---遺傳因素驅(qū)動(dòng)的重大復(fù)雜結(jié)構(gòu)畸形預(yù)后相關(guān)的多組學(xué)分子標(biāo)志物研究，子課題負(fù)責(zé)人，項(xiàng)目編號(hào) 2024YFC2707002，項(xiàng)目經(jīng)費(fèi)200萬(wàn)元。
2) 2023.01-2026.12 國(guó)家自然科學(xué)基金（面上）“宮內(nèi)移植產(chǎn)前治療遺傳性血液病小鼠的綜合評(píng)估”，課題負(fù)責(zé)人，項(xiàng)目編號(hào)82271890，項(xiàng)目經(jīng)費(fèi)52萬(wàn)元。
3) 2021.10-2025.09 上海高水平地方高校創(chuàng)新團(tuán)隊(duì)“出生缺陷防控”，課題負(fù)責(zé)人，項(xiàng)目經(jīng)費(fèi) 1120萬(wàn)元。
4) 2019.12-2024.11 國(guó)家重點(diǎn)研發(fā)計(jì)劃“胚層形成過(guò)程細(xì)胞分子調(diào)控機(jī)制”，子課題負(fù)責(zé)人，項(xiàng)目編號(hào)2019YFA0801402，項(xiàng)目經(jīng)費(fèi)740萬(wàn)元。
5) 2019.01-2022.12 國(guó)家自然科學(xué)基金（面上）“克隆牛重編程的表觀遺傳機(jī)理研究”，課題負(fù)責(zé)人，項(xiàng)目編號(hào)31871484，項(xiàng)目經(jīng)費(fèi)59萬(wàn)元。
6) 2017.09-2022.08 上海市臨床重點(diǎn)專科項(xiàng)目“出生缺陷”，課題負(fù)責(zé)人，項(xiàng)目編號(hào)shslczdzk05705，項(xiàng)目經(jīng)費(fèi)50萬(wàn)元。
論文與專著
1) Zhao XY, Li W, Lv Z, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F, Zhou Q. iPS cells produce viable mice through tetraploid complementation. Nature, 2009. 461(7260): 86-90
2) Wang L, Xue Y, Shen Y, Li W, Cheng Y, Yan X, Shi W, Wang J, Gong Z, Yang G, Guo C, Zhou Y, Wang X, Zhou Q, Zeng F. Claudin 6: a novel surface marker for characterizing mouse pluripotent stem cells. Cell Res, 2012. 22(6): 1082-1085.
3) Lu D, Gong X, Fang Y, Guo X, Chen Y, Yang F, Zhao G, Ma Q, Zeng Y, Zeng F. Correction of RNA splicing defect in beta654-thalassemia mice using CRISPR/Cas9 gene-editing technology. Haematologica. 2022, 107(6):1427-1437.
4) Yang L, Huo Y, Wang M, Zhang D, Zhang T, Wu H, Rao X, Meng H, Yin S, Mei J, Zhang D, Chen X, Lv J, Liu M, Cheng Y, Guan Y, Feng B, Song G, Yi C, Liu M, Zeng F, Wang L, Li D. Engineering APOBEC3A deaminase for highly accurate and efficient base editing. Nat Chem Biol. 2024, 20(9):1176-1187.
5) Li H, Ma Q, Xue Y, Cai L, Bao L, Hong L, Zeng Y, Huang SZ, Finnell RH, Zeng F. Compound heterozygous mutation of AFG3L2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Ca2+ overload. Sci China Life Sci, 2025.68(2):484-501.
6) Fan S, Guo C, Yang G, Hong L, Li H, Ma J, Zhou Y, Fan S, Xue Y, Zeng F#. GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway. J Genet Genomics. 2024 Oct
7) Liwen Bao, Yiye Zhou, Juan Shu, Hua Li, Shubin Xi, Miao Xu, Qin Cai, Xiuqin Dai, Yitao Zeng, Fanyi Zeng#. Impact of telomere length and mitochondrial DNA copy number variants on survival of newborn cloned calves. Theriogenology. 2024 Sep 1;225:1-8. doi: 10.1016/j.theriogenology.
8) Lei Yang, Yanan Huo, Man Wang, Dan Zhang, Tianai Zhang, Hao Wu, Xichen Rao, Haowei Meng, Shuming Yin, Jiale Mei, Dexin Zhang, Xi Chen, Jia Lv, Meizhen Liu, Yiyun Cheng, Yuting Guan, Bo Feng, Gaojie Song, Chengqi Yi, Mingyao Liu, Fanyi Zeng#, Liren Wang#, Dali Li#. Engineering APOBEC3A deaminase for highly accurate and efficient base editing. Nature Chemical Biology. 2024,10.1038/s41589-024-01595-4
9) Dan Lu, Xiuli Gong, Xinbing Guo, Yanwen Chen, Yiwen Zhu, Yudan Fang, Qin Cai, Miao Xu, Hua Yang, Dali Li#, Yitao Zeng, Fanyi Zeng#. Therapeutic Effects of Hematopoietic Stem Cell Derived From Gene-Edited Mice on β654-Thalassemia. Stem Cells. 2024,42(3):278-289
10) Jiahui Wu, Wenchen Shen, Qianhai Fan, Jingzhi Zhang#, Fanyi Zeng#. shRNA Targeting Lentiviral Vector Minus-Strand Product Improves the Viral Titer During Viral Packaging. Molecular Biotechnology. 2024,10.1007/s12033-023-01038-w
11) Jiahui Wu, Yuan Chen, Wenchen Shen, Jingzhi Zhang, Fanyi Zeng#. Reducing the transcriptional read-through rate of a lentiviral vector for β-thalassemia gene therapy. Journal of Gene Medicine. 2024,26(1) : e3640
12) Yanan Chi,?, Guanheng Yang?, Chuanliang Guo, Shaoqing Zhang, Lei Hong, Huixiang Tang, Xiao Sang, JieWang, Ji Ma, Yan Xue# and Fanyi Zeng# Identification of Cellular Compositions in Different Microenvironments and Their Potential Impacts on Hematopoietic Stem Cells HSCs Using Single-Cell RNA Sequencing with Systematical Confirmation. Life 2023, 13, 2157. https://doi.org/10.3390/life13112157
13) Jia-jun Qiu, Yan-na Liu, Hao Wei, Fanyi Zeng# and Jing-bin Yan#. Single-cell RNA sequencing of neural stem cells derived from human trisomic iPSCs reveals the abnormalities during neural differentiation of Down syndrome. Frontiers in Molecular Neuroscience, 16: 1137123,2023
14) Hou-Shi Ma, Xiu-Li Gong, Wen-Xiu Li, Qin Cai, Yan-Wen Chen, Xin-Bing Guo, Zhao-Rui Ren, Fanyi Zeng#, Jing-Bin Yan#. Missense mutation of c.635 T > C in CAPN3 impairs muscle injury repair in a Limb-Girdel Muscular Dystropy Model. Clinical Genetics, 103:663-671, 2023
15) Yanna Liu, Yuehua Zhang, Zhaorui Ren, Fanyi Zeng# and Jingbin Yan#. RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome. Molecules and Cells, 46(4): 219-230,2023
16) Jing-Jing Sun, Qin Cai, Miao Xu, Yan-Na Liu, Wan-Rui Li, Juan Li, Li Ma , Cheng Cai,Xiao-Hui Gong, Yi-Tao Zeng, Zhao-Rui Ren and Fanyi Zeng#. Loss of Protein Function Causing Severe Phenotypes of Female-RestrictedWieacker Wolff Syndrome due to a Novel Nonsense Mutation in the ZC4H2 Gene. Genes. 13(9), 1558,2022.8
17) Guanghui Liu, Guanheng Yang, Guijun Zhao, Chuanliang Guo, Yitao Zeng, Yan Xue#, Fanyi Zeng#. Spatial transcriptomic profiling to identify mesoderm progenitors with precision genomic screening and functional confirmation. Cell Prolif. e13298, 2022.7
18) Shao-Qing Zhang, Xiu-Li Gong, Yi-Ye Zhou, Qingwen Ma, Qin Cai, Guan-Heng Yang, Xin-Bing Guo, Yan-Wen Chen, Miao Xu, Yi-Wen Zhu, Yitao Zeng, Fanyi Zeng#. Maternal Prkce expression in mature oocytes is critical for the first cleavage facilitating maternal-to-zygotic transition in mouse early embryos. Cell Prolif . 18;e13231, 2022.5
19) Dan Lu, Xiuli Gong, Yudan Fang, Xinbing Guo, Yanwen Chen, Fan Yang, Guijun Zhao, Qingwen Ma, Yitao Zeng, Fanyi Zeng#. Correction of RNA splicing defect in beta654-thalassemia mice using CRISPR/Cas9 gene-editing technology. Haematologica. 107(6):1427-1437. 2022 Jun 1.
20) Jiajun Qiu, Xiao Ma, Fanyi Zeng#, Jingbin Yan#. RNA editing regulates IncRNA splicing in human early embryo development. PLOS Computational Biology. 17(12): e 1009630,2021.12
