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師資隊(duì)伍
趙倩
  作者:  2018-12-31

基本信息 >>>

       


  腫瘤細(xì)胞分化與凋亡研究組
  電話:63846590-776920
  郵箱:[email protected]

研究方向>>>

1、 microRNA在白血病細(xì)胞分化中的表達(dá)調(diào)控及其功能

2,、 microRNA在乳腺癌轉(zhuǎn)移中的異常表達(dá)及其功能

3,、 建立轉(zhuǎn)錄因子-microRNA-信號(hào)分子的相互作用網(wǎng)絡(luò)

個(gè)人簡(jiǎn)歷 >>>

       趙倩,女,,研究員,博士生導(dǎo)師。上海交通大學(xué)醫(yī)學(xué)院病理生理學(xué)教研室主任,,上海交通大學(xué)醫(yī)學(xué)科學(xué)研究院PI。主要研究方向?yàn)槟[瘤細(xì)胞分化與凋亡的分子機(jī)制研究,,從信號(hào)轉(zhuǎn)導(dǎo)途徑,、轉(zhuǎn)錄因子調(diào)控以及microRNA的轉(zhuǎn)錄后調(diào)控等多個(gè)層面,對(duì)腫瘤細(xì)胞尤其是白血病細(xì)胞分化與凋亡的分子機(jī)制進(jìn)行深入研究,。入選上海市科委 “青年科技啟明星”,、上海市教委“曙光學(xué)者”;作為課題負(fù)責(zé)人,,獲得科技部“973”項(xiàng)目子課題,、科技部“863”項(xiàng)目、國(guó)家自然科學(xué)基金面上項(xiàng)目,、上海市科委重點(diǎn)項(xiàng)目等各級(jí)課題,;在國(guó)際學(xué)術(shù)期刊如《Blood》, 《Leukemia》, 《Cell Death Differ》, 《Oncogene》等雜志發(fā)表SCI論文27篇。2005年作為第二完成人分別獲得中華醫(yī)學(xué)科技獎(jiǎng)一等獎(jiǎng),,上海市科學(xué)技術(shù)進(jìn)步獎(jiǎng)一等獎(jiǎng)和上海醫(yī)學(xué)科技獎(jiǎng)一等獎(jiǎng),;2010年作為第二完成人獲得國(guó)家自然科學(xué)獎(jiǎng)二等獎(jiǎng)。

科研項(xiàng)目 >>>

81472463 GAPDH在乳腺癌細(xì)胞EMT及乳腺癌轉(zhuǎn)移中的表達(dá)與功能研究  國(guó)家自然科學(xué)基金 2015-01~2018-12  80萬(wàn)元   課題負(fù)責(zé)人

81172521 microRNA 在Snail/Twist誘導(dǎo)乳腺癌細(xì)胞發(fā)生上皮-間質(zhì)轉(zhuǎn)化中的表達(dá)調(diào)控及生物學(xué)功能 國(guó)家自然科學(xué)基金 2012-01~2015-12  57萬(wàn)元   課題負(fù)責(zé)人

  miR-124在乳腺癌細(xì)胞EMT過程和小鼠乳腺癌轉(zhuǎn)移中的功能研究  上海交通大學(xué)晨星青年學(xué)者獎(jiǎng)勵(lì)計(jì)劃 201112~2013-12  15萬(wàn)元   主要責(zé)任人

09SG18 低氧誘導(dǎo)因子-1α(HIF-1α)調(diào)控microRNAs的功能學(xué)研究 上海市教委曙光學(xué)者計(jì)劃 2009-12~2012-12  15萬(wàn)元   課題負(fù)責(zé)人

30870979 低氧誘導(dǎo)因子-1α(HIF-1α)對(duì)microRNA的調(diào)控及其在白血病細(xì)胞分化中的作用 國(guó)家自然基金委,面上項(xiàng)目 2009-01~2011-12  30萬(wàn)元   課題負(fù)責(zé)人

08JC1413500 白血病相關(guān)蛋白AML1-ETO剪切片斷的生物學(xué)功能研究 上海市基礎(chǔ)研究重點(diǎn)項(xiàng)目 2008-10~2010-10  30萬(wàn)元   課題負(fù)責(zé)人

2008AA02Z301 利用小分子化合物和RNAi研究抗白血病蛋白PLSCR1的作用網(wǎng)絡(luò) 科技部863項(xiàng)目 2008-01~2010-12  86萬(wàn)元   課題負(fù)責(zé)人

08JC1413500 白血病相關(guān)蛋白AML1-ETO剪切片斷的生物學(xué)功能研究 上海市科委,,基礎(chǔ)重點(diǎn)項(xiàng)目 ~2010-09  30萬(wàn)元   

論文與專著 >>>

Zhan MN,Yu XT,Tang J,Zhou, CX,Wang CL,Yin QQ,Gong XF,He M,He JR,Chen GQ (通訊作者),Zhao Q#   MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1   Cell Death Dis   2017   8(1):e2529   

Mi L, Zhu F, Yang X, Lu J, Zheng Y, Zhao Q, Wen X, Lu A, Wang M , Zheng M, Ji J, Sun J.   The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells.   Oncogene   2017   36(30):4323-4335   

Liu Y, Li F, Gao F, Xing L, Qin P, Liang X, Zhang J, Qiao X, Lin L, Zhao Q# (通訊作者), Du L.   Periostin promotes tumor angiogenesis in pancreatic cancer via Erk/VEGF signaling    Oncotarget.   2016   7(26):40148-40159   

Zhou CX, Wang CL, Yu An-Lu, Wang QY, Zhan MN, Tang T, Yin QQ, He M, He JR, Chen GQ, Zhao Q#. (通訊作者)   MiR-630 suppresses breast cancer progression by targeting metadherin.   Oncotarget   2016   7(2):1288-1299   

Xia X,Zhang K,Cen G,Jiang T,Cao J,Huang K,Huang C, Zhao Q# (通訊作者),Qiu Z   MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation?of?SMAD4.   Oncotarget   2015   6(25):21046-63   

M He, Q-Y Wang, Q-Q Yin, J Tang, Y Lu, C-X Zhou, C-W Duan, D-L Hong, T Tanaka, G-Q Chen, Q Zhao (通訊作者)   HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation   Cell Death and Differentiation   2013   20(3):408-418   

Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, Yu XT, Cao DX, Chen GQ, He JR, Zhao Q (通訊作者)   MiR-124 Targets Slug to Regulate Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer   Carcinogenesis   2013   34(3):713-22   

Zhang H,Wang Q,Zhao Q# (通訊作者),Di W   MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1   J Ovarian Res.   2013   6(1):84   

Sun J, Zhang D, Zheng Y, Zhao Q, Zheng M, Kovacevic Z, Richardson DR   Targeting the Metastasis Suppressor, NDRG1, Using Novel Iron Chelators: Regulation of Stress Fiber-Mediated Tumor Cell Migration via Modulation of the ROCK1/pMLC2 Signaling Pathway   Mol Pharmacol.   2013   83(2):454-69   

Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ, Zhao Q, Zhou AW, Wang LS, Sun HD, Chen GQ   Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells   Nat Chem Biol   2012   8(5):486-93   

Li D, Yang H, Nan H, Liu P, Pang S, Zhao Q, Karni R, Kamps MP, Xu Y, Zhou J, Wiedmer T, Sims PJ, Wang F   Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model   Blood   2012   120(24):4712-9   

Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ, Zhao Q (通訊作者)   Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer   Carcinogenesis   2011   32(1):2-9   

Yan Z, Yang R, Jiang Y, Yang Z, Yang J, Zhao Q, Lu Y   Induction of Apoptosis in Human Promyelocytic Leukemia HL60 Cells by Panaxynol and Panaxydol   Molecules   2011   29;16 (7):5561-73   

Chen CW, Sowden M, Zhao Q, Wiedmer T, Sims PJ    Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis   J Leukoc Biol.   2011   90 (2):221-33   

Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, He M, Chen GQ, He JR, Zhao Q (通訊作者)   MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11   FEBS Lett.   2011   585(9):1363-1367   

Chen GQ, Zhang J, Zhao Q   Active compounds-based discoveries about the differentiation and apoptosis of leukemic cells   Chinese Sci Bull   2009   54(18): 2759-2765   

Chen S, Han YH, Zheng Y, Zhao M, Yan H, Zhao Q, Chen GQ, Li D   NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells   Leuk Res.   2009   33(8):1108-1113   

Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ   Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its tranional activity independent    Oncogene   2008   27(4):519-27   

Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ   Accumulation of hypoxia-inducible factor-1{alpha} protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid   Haematologica   2008   93(10):1480-7   

Huang Y, Zhao Q (共同第一作者), Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ.   Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells.   Oncogene   2006   25(50):6618-27   

Xue ZH, Jiang Y, Yu Y, Wang LS, Chen GQ,Zhao Q (通訊作者)   Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1α protein   Biochem Biophys Res Commun   2005   332(4): 1140-1145   

Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ   Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells   Haematologica   2005   90(12): 1607-1616   

Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ    Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK   J Biol Chem.   2005   280(52): 42707-42714   

Zhao Q, Tao J, Zhu Q, Jia PM, Dou AX, Li X, Cheng F, Waxman S, Chen GQ, Chen SJ, Lanotte M, Chen Z, Tong JH   Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation   Leukemia   2004   18 (2): 285-92   

Zhao KW, Li X, Zhao Q (共同第一作者), Huang Y, Peng ZG, Shen WZ, Zhao J, Zhou QS, Chen Z, Sims PJ, Wiedmer T, Chen GQ    Protein Kinase Cdelta Mediates Retinoic Acid and Phorbol Myristate Acetate-induced Phospholipid Scramblase 1 Gene Expression: Its Role in Leukemic Cell Differentiation   BLOOD   2004   104(12): 3731-8.   

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