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師資隊伍
傅國輝
  作者:  2018-12-31
 基本信息 >>>    
  
  傅國輝
  腫瘤分子標志物研究及靶向治療研究組
  電話:63846590-776601
  郵箱:[email protected]

研究方向>>>

1,、 消化系統(tǒng)腫瘤發(fā)生發(fā)展的機制探討及其靶向治療的研究

2,、 胃癌的造血干細胞來源和機制

3,、 XPC codon 939 多態(tài)性和黃曲霉素B1相關(guān)的肝癌之間的 流行病學研究

個人簡歷 >>>

       傅國輝,,醫(yī)學博士,,博士生導(dǎo)師,,病理學教授,,留學歸國人員?,F(xiàn)任上海交通大學病理中心主任,,上海交通大學醫(yī)學科學研究院課題組長。入選上海領(lǐng)軍人才,,擔任國家科技獎和教育部科技獎評審專家,,國家自然科學基金終審專家,中國女醫(yī)師協(xié)會病理專家委員會委員,,中華醫(yī)學會上海病理專業(yè)委員會委員,。長期從事腫瘤發(fā)生、分子分型及靶向治療研究,,作為課題負責人承擔國家自然科學基金重點項目和面上項目,、國家863、上海市支撐計劃,、上海市基礎(chǔ)重點項目等多項課題,,參加了國家973項目。發(fā)現(xiàn)了在腫瘤診斷中具有重要應(yīng)用價值的分子標志物,,闡明了致病機制,,建立了腫瘤發(fā)生的新理論。以第一或通訊作者在國際重要學術(shù)期刊Oncogene,、Hepatology,、J Mol Med、Int J cancer,、Br J Hematol,、Biochemistry-US等發(fā)表了系列論文,。長期致力于病理學人才培養(yǎng),指導(dǎo)25名博士,、7名碩士完成學位論文并獲得學位,。獲2012年度上海市育才獎,2013-2014年度上海市三八紅旗手稱號,。

科研項目 >>>

2011BA203191 基于分子標志物的胃癌早期診斷,、分子分型 十二五攀登計劃(子課題) 2013-01~2015-12  240萬元   子課題負責人

SQ2012CC037148 賴氨酸翻譯后修飾及對蛋白質(zhì)功能的調(diào)控作用 973重大研究項目 2013-01~2017-12  80萬元   子課題負責人

81171939 NF-kB p65/miR-23a-27a-24-2 cluster負反饋調(diào)控異常在低分化胃腺癌發(fā)生及紅系分化障礙中作用的研究  國家自然基金委,面上項目 2012-01~2016-12  60萬元   課題負責人

20100073110067 miR-23-24-27 cluster在胃癌發(fā)生中作用的研究 教育部博士點基金 2011-01~2013-12  6萬元   課題負責人

30971115 microRNA在紅細胞終極分化及胃癌發(fā)生中關(guān)聯(lián)作用的研究 國家自然基金,面上項目 2010-01~2012-12  35萬元   課題負責人

30770960 陰離子交換蛋白異常在胃癌發(fā)生中作用的研究 國家自然基金委,面上項目 2008-01~2010-12  34萬元   課題負責人

2008AA02Z120 陰離子交換蛋白1基因突變及表達異常在胃癌診斷治療中的應(yīng)用 863科技部 2008-01~2010-12  288萬元   課題負責人

08JC1413400 NF-κB p65激動劑與胃泌素聯(lián)合降低胃粘膜局部酸堿度對造血干細胞轉(zhuǎn)化為胃癌的阻斷作用研究 上海市科委基礎(chǔ)重點項目 2008-01~2011-12  10萬元   課題負責人

30570697 p16功能調(diào)控的新機制及其腫瘤相關(guān)性研究 國家自然基金委,面上項目 2006-01~2008-12  25萬元   課題負責人

30230160 3蛋白C端域在細胞增殖和凋亡過程中作用的 研究  國家自然基金重點項目 2003-01~2005-12  100萬元   課題負責人

30170348 紅細胞膜帶3蛋白C端域與血型糖蛋白A相互作用的研究 國家自然基金面上項目 2002-01~2002-12  18萬元   課題負責人

39970291 Band3蛋白關(guān)聯(lián)的一種新活性蛋白酶的純化,、基因克隆及其特性研究 國家自然基金面上項目 2000-01~2002-12  11萬元   課題負責人

論文與專著 >>>

Wang T, Fei HJ , Yang Y, Jiang XS, Yan M, Zeng Z, Wu J, Song LJ, Tian H, Fu GH (通訊作者)   Expression of AE1/p16 promoted degradation of AE2 in gastric cancer cells   BMC Cancer   2016   Sep 5;16:716   

Zu LD, Xue YJ, Wang JL, Fu YJ, Wang XM, Xiao G, Hao MG, Sun XQ, Wang YY, Fu GH and Wang JH   The feedback loop between miR-124 and TGF-β pathway plays a significant role in non-small cell lung cancer metastasis   Carcinogenesis   2016   Vol. 37, No. 3, 333–343   

Fei HJ, Zu LD, Wu J, Jiang XS, Wang JL, Chin YE, Fu GH (通訊作者)   PCAF acts as a gastric cancer suppressor through a novel PCAF-p16-CDK4 axis   Am J Cancer Res   2016   1;6(12):2772-2786   

Zhang YC, Ye H, Zeng Z, Chin E, Huang YN, Fu GH (通訊作者)   The NF-κB p65/miR-23a-27a-24 cluster is a target for leukemia treatment.   Oncotarget.    2015   6(32):33554-67.   

Cui Y, Li SB, Peng XC, Wu J, Fu GH (通訊作者)   Trastuzumab Inhibits Growth of HER2-Negative Gastric Cancer Cells Through Gastrin-Initialized CCKBR Signaling.   Dig Dis Sci.   2015   60(12):3631-41   

Guo W, Keener AL, Jing Y, Cai L, Ai J, Zhang J, Fu GH (通訊作者),Wang Z   FOXA1 modulates EAF2 regulation of AR tranional activity, cell proliferation, and migration in prostate cancer cells.   Prostate.   2015   75(9):976-87   

Wei ZH, Guo WH, Wu J, Suo WH, Fu GH (通訊作者)   A nonsense mutation in the Xeroderma pigmentosum complementation group F (XPF) gene is associated with gastric carcinogenesis.    Gene.   2014   537(2): 238-44.   

Zeng Z, Wu HX, Zhan N, Huang YB, Wang ZS, Yang GF, Wang P, Fu GH (通訊作者)   Prognostic significance of USP10 as a tumor-associated marker in gastric carcinoma.   Tumour Biol.    2014   35(4): 3845-53.   

Wang T, Zhao L, Yang Y, Tian H, Suo WH, Yan M, Fu GH (通訊作者)   EGR1 is critical for gastrin-dependent upregulation of anion exchanger 2 in gastric cancer cells   FEBS J   2013   280(1):174-83   

Shen WW, Zeng Z, Zhu WX, Fu GH (通訊作者)   MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells.   J Mol Med (Berl).   2013   91(8): 989-1000.   

Suo WH, Zhang N, Wu PP, Zhao L, Song LJ, Shen WW, Zheng L, Tao J, Long XD, Fu GH. (通訊作者)   Anti-tumor effects of small interfering RNA targeting anion exchanger 1 in experimental gastric cancer.   Br J Pharmacol   2012   165(1):135-47   

Wang P, Mei J, Tao J, Zhang N, Tian H, Fu GH. (通訊作者)   Effects of Helicobacter pylori on biological characteristics of gastric epithelial cells.   Histol Histopathol   2012   27(8):1079-91   

Song LJ, Liu RJ, Zeng Z, Alper SL, Cui HJ, Lu Y, Zheng L, Yan ZW, Fu GH. (通訊作者)   Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK   J Mol Med   2012   90(6):707-18   

Zhao L, Long XD, Yao JG, Wang C, Ma Y, Huang YZ, Li YQ, Wang MF, Fu GH (通訊作者)   Genetic polymorphism of XRCC3 codon 241 and Helicobacter pylori infection-related gastric antrum adenocarcinoma in Guangxi Population, China: a hospital-based case-control study   Cancer Epidemiol.   2011   35(6):564-8   

Wang P, Mei J, Zhang N, Tao J, Tian H, Fu GH (通訊作者)   Helicobacter pylori upregulates the expression of p16(INK4) in gastric cancer cells.   Hepatogastroenterology   2011   58(107-108):846-53   

Wu J,Zhang YC,Suo WH,Liu XB,Shen WW,Tian H,Fu GH (通訊作者)   Induction of anion exchanger-1 translation and its opposite roles in the carcinogenesis of gastric cancer cells and differentiation of K562 cells.   Oncogene   2010   29(13):1987-96   

Tian H, Zhang N, Suo WH, Wang T, Song LJ, Wu J, Liu Q, Shen WW, Fu GH (通訊作者)   Gastrin suppresses the interdependent expression of p16 and anion exchanger 1 favouring growth inhibition of gastric cancer cells   Int J Cancer   2010   1;127(6):1462-74   

Long XD, Ma Y, Huang YZ, Yi Y, Liang QX, Ma AM, Zeng LP, Fu GH. (通訊作者)   Gastrin suppresses the interdependent expression of p16 and anion exchanger 1 favoring growth inhibition of gastric cancer cells.   Mol Carcinog   2010   Jun;49(6):611-8   

Long XD, Ma Y, Zhou YF, Ma AM, Fu GH (通訊作者)   Polymorphism in xeroderma pigmentosum complementation group C codon 939 and aflatoxin B1-related hepatocellular carcinoma in the Guangxi population   Hepatology   2010   52(4):1301-9   

Xu WQ, Song LJ, Liu Q, Zhao L, Zheng L, Yan ZW, Fu GH. (通訊作者)   Expression of anion exchanger 1 is associated with tumor progress in human gastric cancer.   J Cancer Res Clin Oncol   2009   135(10):1323-30   

Liu Q, Song LJ, Xu WQ, Zhao L, Zheng L, Yan ZW, Fu GH. (通訊作者)   Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma.   Mol Med Report   2009   2(2):169-74   

Zhao W, Zhu F, Shen W, Fu A, Zheng L, Yan Z, Zhao L, Fu G (通訊作者)   Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats   Acta Biochim Biophys Sin   2009   41(4):301-8   

Yang Y, Wu PP, Wu J, Shen WW, Wu YL, Fu AF, Zheng L, Jin XL, Fu GH. (通訊作者)   Expression of anion exchanger 2 in human gastric cancer.    Exp Oncol.   2008   30(1):81-7   

Wang Y, Wu SF, Chen GQ, Fu GH (通訊作者)   Effect of block deletions in the C-terminus on the functional expression of human anion exchanger 1 (AE1).    Mol Membr Biol   2007   24(1):65-73   

Wei-Wei Shen, Jun Wu, Li Cai, Bing-Ya Liu, Yan Gao, Guo-Qiang Chen, Guo-Hui Fu (通訊作者)   Expression of anion exchanger 1 sequestrates p16 in cytoplasm in gastric and colonic adenocarcinoma.    Neoplasia   2007   9(10):812-9.   

Xiao-Yan Pan, Guo-Qiang Chen, Li Cai, Guo-Hui Fu (通訊作者)   Anion exchanger 2 mediates the action of arsenic trioxide.    British Journal of Haematology   2006   134:491-499   

Guo-Hui Fu (通訊作者), Yong Wang, Yu-Hui Xi, Zhuo-Wei Guo, Shu-Zhi Bai, Xiao-Bin Liu, Bao-Feng Yang, Guo-Qiang Chen.   The C-terminal 16 residues of band 3 are involved in arsenic trioxide-induced apoptosis.   Journal of Drug Targeting   2005   13(4):235-243   

Guo-Hui Fu (Fu GH) (共同第一作者), Yong Wang, Yu-Hui Xi, Wei-Wei Shen, Xiao-Yan Pan, Wu-Zhong Shen, Guo-Qiang Chen.   Direct interaction and cooperative role of tumor suppressorp16 with band 3(AE1).    FEBS Letters   2005   579:2105-2110   

Guohui Fu (通訊作者),Tianying Wang, Baofeng Yang, Fengxiang Lv, Congning Shi, Lifeng Tian.    Purification and Characterization of the Human Erythrocyte Band3 Protein C-terminal Domain.   Biochemistry-US   2004   43(6):1633-1638.   

Guohui Fu (通訊作者), Hongqing Du, Hongtao Li. Lifeng Tian.    Expression and characterization of 55-kDa transmembrane domain of band 3 and glycophorin A.   Progress in natural Science   2002   12(3):227-231