国产成人嫩模一区二区|超级黄色网页|兔子先生tz|麻豆文化传媒网站官网污|在线播放欧美日韩精品|爱豆影视传媒免费下载|蜜桃影像传媒av剧情|麻豆文化传媒APP最新iOS|陈可心倩女幽魂爱豆传媒|91国视频产,国产传媒播放,想看三级片,网红吃瓜黑料爆料网反差

1. DNA和RNA表觀遺傳去甲基化酶的分子機(jī)制研究和先導(dǎo)藥物發(fā)現(xiàn)；

2. 細(xì)菌和哺乳動(dòng)物細(xì)胞內(nèi)脂肪酸合成途徑關(guān)鍵酶的分子機(jī)制研究和先導(dǎo)藥物發(fā)現(xiàn),；

3. 哺乳動(dòng)物細(xì)胞內(nèi)核苷酸合成途徑關(guān)鍵酶的代謝機(jī)制研究和先導(dǎo)藥物發(fā)現(xiàn),；

張良，博士,，研究員，博士生導(dǎo)師，腫瘤化學(xué)生物學(xué)課題組組長(zhǎng),，國(guó)家優(yōu)秀青年科學(xué)基金獲得者，上海市曙光學(xué)者,，上海交通大學(xué)唐立新優(yōu)秀學(xué)者獎(jiǎng)獲得者,，上海交通大學(xué)基礎(chǔ)醫(yī)學(xué)院杰出員工。團(tuán)隊(duì)主要致力于腫瘤相關(guān)分子調(diào)控機(jī)制研究和先導(dǎo)藥物發(fā)現(xiàn),。通過(guò)綜合運(yùn)用化學(xué)生物學(xué),、結(jié)構(gòu)生物學(xué)、細(xì)胞生物學(xué),、代謝組學(xué)和藥學(xué)等技術(shù)手段,，闡明人體細(xì)胞中核酸表觀遺傳調(diào)控（DNA/RNA甲基化-去甲基化）、脂肪酸和核苷酸在細(xì)胞內(nèi)合成過(guò)程中關(guān)鍵酶的分子機(jī)制,，明確其在腫瘤發(fā)生發(fā)展過(guò)程中的作用和調(diào)控機(jī)制,，并建立高通量實(shí)體藥物篩選體系,，篩選靶向性抗腫瘤先導(dǎo)藥物。近年來(lái)以通訊作者在化學(xué)生物學(xué)國(guó)際旗艦學(xué)術(shù)刊物(Nature Chemical Biology,、Nature Communications,、Cell Research、Chemical Science,、PNAS,、Elife等)上發(fā)表一系列SCI論文，獲得并轉(zhuǎn)化多項(xiàng)國(guó)際/美國(guó)/國(guó)內(nèi)技術(shù)發(fā)明專(zhuān)利,。

1. 國(guó)家自然科學(xué)基金委面上項(xiàng)目,，2021/01～2024/12，63萬(wàn)元,，主持,；

2. 國(guó)家自然科學(xué)基金委重大研究計(jì)劃（培育），2019/01～2021/12,，60萬(wàn)元,，主持；

3. 國(guó)家自然科學(xué)基金委優(yōu)秀青年科學(xué)基金項(xiàng)目,，2018/01～2020/12,，130萬(wàn)元，主持,；

4. 國(guó)家自然科學(xué)基金委面上項(xiàng)目,，2016/01～2019/12，65萬(wàn)元,，主持,；

5. 上海市2022年度“科技創(chuàng)新行動(dòng)計(jì)劃”生物醫(yī)藥科技支撐專(zhuān)項(xiàng)項(xiàng)目，2022/04～2025/03,，20萬(wàn)元,，主持；

6. 上海市2022年度“科技創(chuàng)新行動(dòng)計(jì)劃”生物醫(yī)藥科技支撐專(zhuān)項(xiàng)項(xiàng)目,，2020/09～2023/09,，20萬(wàn)元，主持,；

7. 上海市“曙光計(jì)劃”項(xiàng)目,，2021/01~2024/12，15萬(wàn)元,，主持,；

8. 上海交通大學(xué)海外人才引進(jìn)項(xiàng)目，2015/01～2019/12，200萬(wàn),，主持,；

9. 985新藥平臺(tái)隊(duì)伍配套，2015/03～2018/12,，30萬(wàn),，主持；

1. Y.J. Mu^#, L. Zhang^#, *, J.Y. Hu^#, J.S. Zhou, H.W. Lin, C. He, H.Z. Chen*, and L. Zhang*. A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA. Nat. Chem. Biol., 2022, 18, 733.

2. R.Y. Shang, J. Cui, J.X. Li, X.X. Miao, L. Zhang, D.D. Xie, L. Zhang, H.W. Lin, W.H. Jiao. Nigerin and ochracenes J?L, new sesquiterpenoids from the marine sponge symbiotic fungus Aspergillus niger. Tetrahedron, 2022, 104, 132599.

3. P. Zhang^#, L. Zhang^#, *, Z.Y. Hou, H.W. Lin, H. Gao*, and L. Zhang*. Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2. Biochem. Biophys. Res. Commun., 2021, 586, 1.

4. J.S. Zhou^#, L. Zhang^#, L.P. Zeng^#, L. Yu^#, Y.Y. Duan^#, S.Q. Shen^#, J.Y. Hu, P. Zhang, W.Y. Song, X.X. Ruan, J. Jiang, Y.N. Zhang, L. Zhou, J. Jia, X.D. Hang, C.L Tian, H.Z. Chen*, J.E. Cronan*, H.K. Bi*, L. Zhang*. Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis. Nat. Commun., 2021, 12, 6932.

5. G.K. Chen^#, J.S. Zhou^#, Y.L. Zuo, W.P. Huo, J. Peng, M. Li, Y.N. Zhang, T.T. Wang, L. Zhang, L. Zhang*, H.H. Liang*. Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa. Elife. 2021, 10, e67289.

6. S.H. Xiao^#, S.Q. Guo, J. Han, Y.L. Sun, M.C. Wang, Y.T. Chen, X.Y. Fang, F. Yang, Y.J. Mu, L. Zhang, Y.L. Ding, N.X. Zhang, H.L. Jiang, K.X. Chen, K.H. Zhao, C. Luo, S.J. Chen*. High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases. Nucleic Acids Res., 2021, 50, e9.

7. J.S. Zhou, L. Zhang, L. Zhang*. Advances on Mechanism and Drug Discovery of Type-II Fatty Acid Biosynthesis Pathway. Acta Chimica Sinia, 2020, 78, 1383.

8. T. R. Fu^#, L. P. Liu^#, Q. L. Yang^#, Y. X. Wang, P. Xu, L. Zhang, S. E. Liu, Q. Dai, Q. J. Ji, G. L. Xu, C. He, C. Luo* and L. Zhang*. Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine. Chem. Sci. 2019, 10, 7407.

9. S. Q. Shen^#, X. D Hang^#, J. J. Zhuang^#, L. Zhang*, H. K. Bi* and L. Zhang*. A back-door Phenylalanine coordinates the stepwise hexameric loading of acyl carrier protein by the fatty acid biosynthesis enzyme β-hydroxyacyl-acyl carrier protein dehydratase (FabZ). Int. J. Biol. Macromol. 2019, 128, 5.

10. X. Zhang^#, L. H. Wei^#, Y. X. Wang^#, Y. Xiao^#, J. Liu, W. Zhang, N. Yan, G. B. Amu, X. J. Tang, L. Zhang* and G. F. Jia*. Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates. Proc. Natl. Acad. Sci. U.S.A. 2019, 116, 2919.

11. L. Zhang, J. F. Xiao, J. R. Xu, T. R. Fu, Z. W. Cao, L. Zhu, H. Z. Chen, X. Shen, H. L. Jiang and L. Zhang*. Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis. Cell Res. 2016, 26, 1330.

12. L. Zhang^#, W. Z. Chen^#, L. M. Iyer, J. Hu, G. Wang, Y. Fu, M. Yu, Q. Dai, L. Aravind and C. He. A TET homologue protein from Coprinopsis cinerea (CcTET) that biochemically converts 5-Methylcytosine to 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxylcytosine. J. Am. Chem. Soc. 2014, 136, 4801.

13. L. Zhang^#, K. E. Szulwach^#, G. C. Hon^#, C. X. Song, B. Park, M. Yu, X. Y. Lu, Q. Dai, X. Wang, C. R. Street, H. P. Tan, J. H. Min, B. Ren, P. Jin, C. He. Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing. Nat. Commun. 2013, 4, 1517.

14. L. Zhang, X. Y. Lu, J. Y. Lu, H. H. Liang, Q. Dai, G. L. Xu, C. Luo, H. L. Jiang, C. He. Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat. Chem. Biol. 2012, 8, 328.

15. C. He, L. Zhang, C. X. Song, M. Yu. Composition and Methods Related to Modification of 5-methylcytosine (5mC). 2012, Publication number: WO WO2012138973 A3 (PCT專(zhuān)利).

16. K. Jonas, C. He, T. A. Clark, L. Zhang, X. Y. Lu. Identification of 5-methyl-c in nucleic acid templates. 2013, Publication number: WO2013163207 A1 (PCT專(zhuān)利).