肖澤宇 教授
可視化藥物遞送研究組
電話：63846590-776415
郵箱：xiaozeyu@shsmu.edu.cn
研究方向
分子影像，藥物遞送，納米醫(yī)學(xué)
主要包括：
用于分子影像學(xué)、分析化學(xué)、化學(xué)生物學(xué)、納米醫(yī)學(xué)手段開展轉(zhuǎn)化醫(yī)學(xué)研究：
1. 發(fā)展基于活體拉曼光學(xué)影像、核酸（核酸適體、DNA自組裝）化學(xué)的診療一體化納米體系，用于腫瘤的可視化檢測和治療，如術(shù)中診療殘余腫瘤、藥物劑量監(jiān)控、克服靶向藥物耐藥、分子靶向治療可視化診治等。
2. 利用生物可降解，生物安全的高分子聚合物構(gòu)建納米緩控釋藥物輸送體系，開發(fā)其在口服結(jié)腸靶向給藥中的應(yīng)用
個人簡歷
上海交通大學(xué)醫(yī)學(xué)院特聘教授，博士生導(dǎo)師，國家海外高層次青年人才，上海市衛(wèi)生健康學(xué)科帶頭人，上海市高層次人才。北京大學(xué)醫(yī)學(xué)部藥學(xué)院學(xué)士；中國科學(xué)院化學(xué)所與美國佛羅里達(dá)大學(xué)聯(lián)合培養(yǎng)博士；美國麻省理工學(xué)院與哈佛大學(xué)醫(yī)學(xué)院癌癥納米交叉研究中心Robert Langer實(shí)驗(yàn)室博士后；2014年底起在上海交通大學(xué)醫(yī)學(xué)院任現(xiàn)職至今。從事活體拉曼成像分析及疾病診療應(yīng)用的研究，發(fā)表論文60余篇，總引用達(dá)8000余次; 近年來以通訊作者在Nat Biotechnol, Chem, J Am Chem Soc, Nat Commun. Adv Sci, Nano Lett., ACS Nano, Anal Chem等雜志發(fā)表論文, 代表性工作被Nat Biotechnol以Research Briefing進(jìn)行亮點(diǎn)介紹和評述。申請國際國內(nèi)專利13件，授權(quán)7件（含PCT2件），其中1件專利成果在人體臨床研究中展示安全及有效性。主持國家重點(diǎn)研發(fā)計(jì)劃課題、國自然國際地區(qū)合作項(xiàng)目等國家級項(xiàng)目7項(xiàng)。獲哈佛大學(xué)華人科學(xué)家獎，美國癌癥研究協(xié)會青年女科學(xué)家獎、全國顛覆性技術(shù)創(chuàng)新大賽總決賽最高獎、上藥杏林育才獎等。現(xiàn)任美國化學(xué)會Anal Chem 雜志顧問委員，中國化學(xué)會分子醫(yī)學(xué)專委會委員；中國抗癌協(xié)會納米腫瘤學(xué)專委會委員；中國化學(xué)會女化學(xué)工作者委員會委員。
科研項(xiàng)目
1. 國家重點(diǎn)研發(fā)計(jì)劃納米科技重點(diǎn)專項(xiàng)，多模塊可編程納米藥物的活體動態(tài)可視化研究，2020.11 ～ 2025.10，212萬元，課題負(fù)責(zé)人；
2. 國家自然科學(xué)基金國際(地區(qū)）合作項(xiàng)目，功能模塊化光動力藥物用于克服非小細(xì)胞肺癌旁路激活耐藥及序貫療效監(jiān)控，2022.01 ～ 2024.12，140萬元，課題負(fù)責(zé)人
3. 國家自然科學(xué)基金面上項(xiàng)目，DNA模塊化核酸納米遞送系統(tǒng)激活巨噬細(xì)胞cGAS-STING增效抗腫瘤免疫，2025.01 ～ 2028.12，50萬元，課題負(fù)責(zé)人
4. 國家自然科學(xué)基金面上項(xiàng)目，拉曼納米探針用于活性氧異常疾病的醫(yī)學(xué)分析研究，2019.01 ～ 2022.12，64萬元，課題負(fù)責(zé)人；
5. 國家自然科學(xué)基金面上項(xiàng)目，核酸識體納米藥物在組織臟器的三維精準(zhǔn)分布及靶向識別，2017.01 ～ 2020.12，62萬元，課題負(fù)責(zé)人；
6. 國家自然科學(xué)基金面上項(xiàng)目，DNA自主裝納米診療系統(tǒng)：構(gòu)建及術(shù)中成像介導(dǎo)下前列腺癌細(xì)胞清除的問題研究，2015.01 ～ 2018.12，73萬元，課題負(fù)責(zé)人；
7. 國家自然科學(xué)基金應(yīng)急管理項(xiàng)目，SP-A核酸適體拉曼納米探針用于胎肺發(fā)育及異常的產(chǎn)前診斷研究，2018.01 ～ 2018.12，20萬元，課題負(fù)責(zé)人；
8. 國家重點(diǎn)研發(fā)計(jì)劃，新型冠狀病毒（2019-nCoV）核酸現(xiàn)場快速檢測設(shè)備及試劑的研發(fā)，2020.01 ～ 2020.04，100萬元，學(xué)術(shù)骨干；
論文與專著
5篇代表作：
1. Gao S, Zhang Y, Cui K, Zhang S, Qiu Y, Liao Y, Wang H, Yu S, Ma L, Chen H, Ji M, Fang X*, Lu W*, Xiao Z*. Self-stacked small molecules for ultrasensitive substrate-free Raman imaging in vivo . Nat Biotechnol 2024, doi: 10.1038/s41587-024-02342-9.Highlighted by research briefing of Nat Biotechnol
2. Zhang Y, Zhang W, Qiu Y, Cui K, Li X, Hao W, Luo A, Xiao Z*. Molecular engineering of a SICTERS small molecule with superior in vivo Raman imaging and photothermal performance. J Am Chem Soc. 2025, doi: 10.1021/jacs.4c16411
3. Zhao N, Wu W, Wang Y, Song K, Chen G, Chen Y, Wang R, Xu J, Cui K, Chen H, Tan W, Zhang J*,Xiao Z*. DNA-modularized construction of bivalent ligands precisely regulates receptor binding and activation. Chem 2023, 9, 1-23
4. Chen G, Li X, Xu W, Wang H, Jiang Y, Shi R, Zhu C, Xiao Z*. Inflammation Targeting-Triggered Healing Hydrogel for In Situ Reconstruction of Colonic Mucosa. Adv Sci 2025, doi: 10.1002/advs.202411010
5. Chen Y, Li R, Duan Q, Wu L, Li X, Luo A, Zhang Y, Zhao N, Cui K, Wu W, Liu T, Wan J, Deng L, Li G*, Hou L*, Tan W*, and Xiao Z*. A DNA-modularized STING agonist with macrophage-selectivity and programmability for enhanced anti-tumor immunotherapy. Adv Sci 2024, 11(32):e2400149. (front over)
其它通訊作者論文：
6. Xu J, Li Z, Tong Q, Zhang S, Fang J, Wu A, Wei G, Zhang C, Yu S, Zheng B, Lin H, Liao X, Xiao Z*, Lu W. CD133+PD-L1+?cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma. Nat Commun. 2025, 16(1):895.
7. Covalent Organic Framework-Structured?Raman?Probes for Ultrasensitive In Vivo Bioimaging. Cui K, Li R, Li M, Qiu Y, Wang H, Wu W, Liu T, Zhang W, Xiao Z*. Anal Chem. 2024; 96(29):11800-11808.
8. Ding D, Zhao H, Wei D, Yang Q, Yang C, Wang R, Chen Y, Li L, An S, Xia Q, Huang G, Liu J*, Xiao Z*, Tan W*, The First-in-human Whole-body Dynamic Pharmacokinetics Study of Aptamer. Research, A Science Partner Journal, 2023, 6: 0126.
9. Molecular Engineering of Aptamer to Solubilize Hydrophobic NIR Photosensitizer for Enhanced Cancer Photodynamic Therapy, Zhang R, Ji D*, Yao D, Xiao Z*, Tan W*. CCS Chemistry, 2024, 6, 1240–1254，
10. Cui K, Li R, Zhang Y, Qiu Y, Zhao N, Cui Y, Wu W, Liu T, Xiao Z*. Molecular planarization of Raman probes to avoid background interference for high-precision intraoperative imaging of tumor micrometastases and lymph nodes. Nano Lett. 2022, 22(23), 9424–9433
11. Zhang Y, Cui Y, Li M, Cui K, Li R, Xie W, Liu L, Xiao Z*. DNA-assembled visible nanodandelions with explosive hydrogen-bond breakage achieving uniform intra-tumor distribution (UITD)-guided photothermal therapy. Biomaterials 2022, 282, 121381.
12. Cui K, Zhang Y, Chen G, Cui Y, Wu W, Zhao N, Liu T, Xiao Z*. Molecular regulation of polymeric Raman probes for ultrasensitive microtumor diagnosis and noninvasive microvessle imaging. Small 2022, 18(41):e2203227
13. Xia F, He A, Zhao H, Sun Y, Duan Q, Abbas S J, Liu J*, Xiao Z*, Tan W*. Molecular Engineering of Aptamer Self-assemblies Increases in Vivo Stability and Targeted Recognition. ACS Nano 2022,16,1,169-179
14. Fan C, Zhao N, Cui K, Chen G, Chen Y, Wu W, Li Q, Cui Y, Li R, Xiao Z*. Ultrasensitive Exosome Detection by Modularized SERS Labeling for Postoperative Recurrence Surveillance. ACS Sens. 2021 6(9):3234-3241.
15. Gao S, Yu S, Zhang Y, Wu A, Zhang S, Wei G, Wang H*, Xiao Z*, Lu W*. Molecular engineering of near-Infrared-II photosensitizers with steric-hindrance effect for image-guided cancer photodynamic therapy. Adv. Func. Mater. 2021, 31(14), 2008356
16. Gao S, Wei G, Zhang S, Zheng B, Xu J, Chen G, Li M, Song S, Fu W, Xiao Z*, Lu W* Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics. Nat Commun. 2019,10(1):2206.
17. Gu X, Qiu Y, Lin M, Cui K, Chen G, Chen Y, Fan C, Zhang Y, Xu L, Chen H, Wan JB, Lu W*, Xiao Z*. CuS Nanoparticles as a Photodynamic Nanoswitch for Abrogating Bypass Signaling To Overcome Gefitinib Resistance. Nano Lett. 2019,19(5):3344-3352 Qiu
18. Y, Lin M, Chen G, Fan C, Li M, Gu X, Cong S, Zhao Z, Fu L, Fang X*, Xiao Z*. Photodegradabl CuS SERS probes for intraoperative residual tumor detection, ablation and self-clearance. ACS Appl Mater Interfaces 2019, 11(26):23436-23444
19. Zheng B, Xu J, Chen G, Zhang S, Xiao Z*, Lu W*. Bacterium-Mimicking Vector with Enhanced Adjuvanticity for Cancer Immunotherapy and Minimized Toxicity. Adv. Func. Mater. 2019, 29(33):1901437
20. Wu W, Xiao Z*. A deep learning “ticket” for single-molecule analysis of protein stoichiometry. Sci China Chem 2019. 62(10): 1269-1270
21. Xu J, Yu S, Wang X, Qian Y, Wu W, Zhang S, Zheng B, Wei G, Gao S, Cao Z, Fu W, Xiao Z*, Lu W*. High Affinity of Chlorin e6 to Immunoglobulin G for Intraoperative Fluorescence Image-Guided Cancer Photodynamic and Checkpoint Blockade Therapy. ACS Nano 2019, 13,10242-10260
22. Qiu Y, Zhang Y, Li M, Chen G, Fan C, Cui K, Wan J, Han A, Ye J*, Xiao Z* Intraoperative detection and eradication of residual microtumors with gap-enhanced Raman tags. ACS Nano 2018, 12(8):7974-7985.
23. Cui K, Fan C, Chen G, Qiu Y, Li M, Lin M, Wan JB, Cai C, Xiao Z*. para-Aminothiophenol Radical Reaction-Functionalized Gold Nanoprobe for One-to-All Detection of Five Reactive Oxygen Species in Vivo. Anal Chem. 2018, 90, 12137-12144
24. Li M, Qiu Y, Fan C, Cui K, Zhang Y, Xiao Z*Design of SERS nanoprobes for Raman imaging: materials, critical factors and architectures. Acta Pharm Sin B. 2018, 8(3):381-389
25. Lu L, Chen G, Qiu Y, Li M, Liu D, Hu D, Gu X, Xiao Z* Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies. Sci Bull 2016, 61(9):670-681
專著：
1. Hu W, Wang H, Xu W, Li M, Su H, Zhang Y, Li R, Xiao Z*(Corresponding Author) Raman Nanoprobes for In Vivo Medical Applications. Encyclopedia of Nanomaterials, Elsevier Ltd, 2023, vol. 3, pp. 391–410. ISBN：B978-0-12-822425-0.00098-1
2. Qiu Y, Lu L, Hu D, Xiao Z*(Corresponding Author) Copper Sulfide nanoparticles: from synthesis to biomedical applications. Nano Based Drug Delivery, IAPC Publishing, 2015, 516-534, ISBN 978-953-56942-2-9
