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師資隊(duì)伍
周斌兵
  作者:  2018-12-31

基本信息 >>>

                                                                                                20459
 周斌兵
 藥理學(xué)與化學(xué)生物學(xué)系
 電話:021-63846590-776940
 郵箱:[email protected]

研究方向>>>

1. 兒童白血病耐藥復(fù)發(fā)基因組學(xué)研究和復(fù)發(fā)克隆演化分子機(jī)制及轉(zhuǎn)化應(yīng)用,。

2. 基因損傷應(yīng)答(DDR)在兒童白血病耐藥復(fù)發(fā)中的作用及轉(zhuǎn)化應(yīng)用,。

3. 藥物和腫瘤代謝在兒童白血病耐藥復(fù)發(fā)中的機(jī)制及轉(zhuǎn)化應(yīng)用

個(gè)人簡(jiǎn)歷 >>>

周斌兵,1987年復(fù)旦大學(xué)本科畢業(yè),,1993年獲加州大學(xué)伯克利分校生物化學(xué)博士學(xué)位,,1994-1998年哈佛醫(yī)學(xué)院細(xì)胞生物學(xué)博士后師從Marc W. Kirschner。前期與Steve Elledge 等合作提出DNA損傷應(yīng)答(DNA damage response, DDR)的理論,,揭示真核細(xì)胞對(duì)DNA損傷類(lèi)化療藥物有一個(gè)涉及細(xì)胞可塑性的適應(yīng)和生存反應(yīng),。2012年回國(guó)前擔(dān)任美國(guó)輝瑞制藥公司癌癥研究所高級(jí)總監(jiān),負(fù)責(zé)涉及小分子,、抗體和抗體聯(lián)體藥方面10多個(gè)抗癌藥物的研究和開(kāi)發(fā),其中兩個(gè)已在美國(guó)上市(Tykerb和Besponsa),、兩個(gè)進(jìn)入III期臨床。2012年入選國(guó)家特聘專(zhuān)家,,2015年獲得上海交通大學(xué)王寬誠(chéng)講席教授稱號(hào),,現(xiàn)任衛(wèi)生部?jī)和耗[瘤重點(diǎn)實(shí)驗(yàn)室執(zhí)行主任,上海交通大學(xué)醫(yī)學(xué)院藥理學(xué)與化學(xué)生物學(xué)系系主任,,上海交通大學(xué)醫(yī)學(xué)院兒科轉(zhuǎn)化醫(yī)學(xué)研究所所長(zhǎng),。在國(guó)際著名雜志刊物上發(fā)表SCI論文40余篇,其中4篇Nature系列,,2篇Cancer Cell,,總他引次數(shù)超過(guò)7500次。獲得美國(guó)專(zhuān)利4項(xiàng),。曾獲中美藥協(xié)杰出研究獎(jiǎng)(SAPA -NE Research Award, 2010),、加州大學(xué)伯克利分校校長(zhǎng)獎(jiǎng)(1991-1992)等。

科研項(xiàng)目 >>>

1. 國(guó)家自然科學(xué)基金委面上項(xiàng)目,,2020/01~2023/12,,55萬(wàn),課題負(fù)責(zé)人,;

2. 國(guó)家自然科學(xué)基金委中以國(guó)合項(xiàng)目,,2018/102021/09,160萬(wàn)元,,課題負(fù)責(zé)人,;

3. 國(guó)家自然科學(xué)基金委重點(diǎn)項(xiàng)目,2016/01~2020/12,,270萬(wàn),,課題負(fù)責(zé)人;

4. 上海市科學(xué)技術(shù)委員會(huì)優(yōu)秀學(xué)術(shù)帶頭人計(jì)劃,2016/05~2019/04,,40萬(wàn),,課題負(fù)責(zé)人;

5. 國(guó)家科技部973項(xiàng)目,,2015/01~2019/12,,130萬(wàn),子課題負(fù)責(zé)人,;

6. 國(guó)家自然科學(xué)基金委面上項(xiàng)目,,2014/01~2017/12,75萬(wàn),,課題負(fù)責(zé)人,;

論文與專(zhuān)著 >>>

1. Yang F, Brady SW, Tang C, Sun H, Du L, Barz MJ, Ma X, Chen Y, Fang H, Li X, Kolekar P, Pathak O, Cai J, Ding L, Wang T, von Stackelberg A, Shen S, Eckert C, Klco JM, Chen H, Duan C, Liu Y, Li H, Li B, Kirschner-Schwabe R*, Zhang J*, Zhou, B.-B. *.(2021) Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse. Nat Cancer, 2(8):819-834.

2. Li, B., Brady, S.W., Ma, X., Shen, S., Zhang, Y., Li, Y., Szlachta, K., Dong, L., Liu, Y., Yang, F., Wang, N., Flasch, D.A., Myers, M.A., Mulder, M.A., Ding, L., Liu, Y., Tian, L., Hagiwara, K., Xu, K., Zhou, X., Sioson, E., Wang, T., Yang, L., Zhao, J., Zhang, H., Shao, Y., Sun, H., Sun, L., Cai, J., Sun, H., Lin, T., Du, L., Li, H., Rusch, M., Edmonson, M.N., Easton, J., Zhu, X., Zhang, J., Cheng, C., Raphael, B.J., Tang, J., Downing, J.R., Alexandrov, L.B., Zhou, B.-B. *, Pui, C.*, Yang, J.J.*, Zhang, J.*.(2020) “Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia”Blood ,135 (1): 41–55.

3. Chen,Y., Tang, C., Zhang, M., Huang, W., Xu, Y., Sun, H., Yang, F., Song, L.,  Wang, H., Mu,L., Li, M., Zheng, W., Miao, Y., Ding, L., Li, B., Shen,S., Liu, S., Li, H., Zhu, Z., Chen,H., Tang,Z., Chen,J., Hong, D., Chen,H.*,  Duan C.*, Zhou, B.-B.* (2019) “Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia.” Leukemia, 33(10):2365-2378.

4. Du, L., Yang, F.*, Fang, H., Sun, H.,  Chen, Y., Xu, Y., Li, H., Zheng, L., Zhou, B.-B.* (2019) “AICAr suppresses cell proliferation by inducing NTP and dNTP pool imbalances in acute lymphoblastic leukemia cells”, FASEB J., 33(3): 4525-4537.

5. Wang D, Chen Y, Fang HS, Zheng L, Li Y, Yang F, Xu Y, Du LJ, Zhou B.-B.*, Li H.*2018“Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5-Fluorouracil.” J Cell Mol Med22(12): 6202-6212

6. Tang C, Li MH, Chen YL, Sun HY, Liu SL, Zheng WW, Zhang MY, Li H, Fu W, Zhang WJ, Liang AB, Tang ZH, Hong DL, Zhou B.-B.*,,Duan C*. (2018) “Chemotherapy-induced niche perturbs hematopoietic reconstitution in B-cell acute lymphoblastic leukemia.”J Exp Clin Cancer Res,,29;37(1):204

7. Li, B., Li, H., Bai, Y., Kirschner-Schwabe, R., Yang, J., Chen, Y., Lu, G., Tzoneva, G., Ma, X., Wu, T., Li, W., Lu, H., Ding, L., Liang, H., Huang, X., Yang, M., Jin, L., Kang, H., Chen, S., Du, A., Shen, S., Ding, J., Chen, H., Chen, J., von Stackelberg, A., Gu, L., Zhang, J., Ferrando, A., Tang, J.*, Wang, S.*, Zhou, B.-B.* (2015) “Negative feedback-defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL.” Nat Med, 21(6):563-571. (cover story)

8. Zhou, B.-B.*, Peyton, M., He, B., Liu, C., Girard, L., Caudler, E., Lo, Y., Baribaud, F.,  Mikami, I., Reguart, N., Yang, G., Yao, W., Vaddi, K., Gazdar, A., Friedman, S., Jablons, D., S., Newton, R., Fridman, J., Minna, J, Scherle, P. (2006)  “Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer.”  Cancer Cell, 10(1): 39-50.(cover story)

9. Zhou, B.-B. and Elledge, S. J.  (2000)  “The DNA damage response: putting checkpoints in perspective.” Nature, 408, 433-439.