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師資隊伍
王昊
  作者:  2018-12-31

基本信息 >>>

                                                                            EC027

王昊

藥理學與化學生物學系

電話:63846590-776671

郵箱:[email protected]


研究方向>>>

神經(jīng)退行性疾病發(fā)病新機制及新藥研究

個人簡歷 >>>

王昊教授課題組依托于國家雙一流和上海市高水平地方高校建設(shè)學科——上海交通大學醫(yī)學院藥學學科,,現(xiàn)有教授1名、副研究員2名、實驗師1名,、博士后1名、在讀研究生5名,。近20年來,,課題組聚焦于神經(jīng)退行性疾病發(fā)病新機制、干預(yù)新靶點及新藥物研究,,先后承擔和參與國家重點基礎(chǔ)研究(973計劃)課題1項,、國家重大新藥創(chuàng)制科技重大專項1項、國家自然科學基金項目12項及上海市科委重點課題3項,,在Cell Death & Differentiation,、Advanced ScienceAging Cell等高水平雜志發(fā)表論文60余篇,,獲國內(nèi)外發(fā)明專利10余項,。研究成果獲教育部科技進步獎一等獎、教育部自然科學獎二等獎,、中華醫(yī)學科技獎二等獎等,。課題組長王昊教授擔任中國藥理學學會理事、上海市藥學會理事,、藥理學專委會副主任委員,,獲上海市教育系統(tǒng)三八紅旗手、上藥杏林育才獎等,,培養(yǎng)博士研究生5人,,碩士研究生8人,4人獲得國家獎學金,。

科研項目 >>>

近五年主持或參與的國家級,、市級項目/課題

1. 上海市 科技創(chuàng)新行動計劃科普專項項目,21DZ2315000,,上海交通大學醫(yī)學院醫(yī)學科學青少年科學創(chuàng)新實踐工作站,,2021/06-2023/0260萬元,,在研,,主持2. 國家自然科學基金面上項目,,81973297α7煙堿型乙酰膽堿受體介導的中樞抗炎通路的轉(zhuǎn)錄后調(diào)節(jié)新機制,,2020/01-2023/12,,55萬元,在研,,主持

3. 上海市科技創(chuàng)新行動計劃基礎(chǔ)研究領(lǐng)域重點項目,,19JC1413100,基于HDX-MS技術(shù)的M1膽堿受體與Gαq/11蛋白偶聯(lián)障礙的分子機制研究,,2019/11-2022/10,,78萬元,在研,,主持

4. 上海交通大學轉(zhuǎn)化醫(yī)學交叉研究基金重點項目,,ZH2018ZDA23,抗老年癡呆中藥有效成分的大數(shù)據(jù)挖掘及多靶點活性的藥理學研究,,2019/01-2021/12,,50萬元,在研,,主持

5.國家自然科學基金面上項目,,81872841M1受體選擇性激活和Gαq-PKC信號偏好的變構(gòu)新位點發(fā)掘及調(diào)控機制研究,,2019/01-2022/12,,60萬元,在研,,參與。

論文與專著 >>>

【論文與專著】

1) Song C, Shi J, Zhang P, Zhang Y, Xu J, Zhao L, Zhang R, Wang H, Chen H. Immunotherapy for Alzheimer's disease: targeting β-amyloid and beyond. Transl Neurodegener. 2022 Mar 18;11(1):18.

2) Song C, Zhang YF, Huang WY, Shi JY, Huang Q, Jiang MJ, Qiu Y, Wang T, Chen HZ, Wang H. Circular RNA Cwc27 contributes to Alzheimer’s disease pathogenesis by repressing Pur-α activity. Cell Death Differ. 2022, 29(2):393-406.

3) Hu YB, Zhang YF, Ren RJ, Dammer EB, Xie XY, Chen SW, Huang Q, Huang WY, Zhang R, Chen HZ, Wang H, Gang Wang. microRNA-425 loss mediates amyloid plaque microenvironment heterogeneity and promotes neurodegenerative pathologies. Aging Cell. 2021, 20(10):e13454.

4) Song C, Shi J, Xu J, Zhao L, Zhang Y, Huang W, Qiu Y, Zhang R, Chen H, Wang H. Post-transcriptional regulation of α7 nAChR expression by miR-98-5p modulates cognition and neuroinflammation in an animal model of Alzheimer's disease. FASEB J. 2021; 35(6):e21658.

5)  Zhang Q, Song Q, Gu X, Zheng M, Wang A, Jiang G, Huang M, Chen H, Qiu Y, Bo B, Tong S, Shao R, Li B, Wang G, Wang H, Hu Y, Chen H, Gao X. Multifunctional nanostructure RAP-RL rescues Alzheimer's cognitive deficits through remodeling the neurovascular unit. Adv Sci (Weinh). 2020; 8(2):2001918.

6) Chen L, Zhang S, Tian W, Huang L, Jiang X, Chen X, Wang H, Su D. Cerebral spinal fluid cholinergic biomarkers predict postoperative cognitive dysfunction in aged patients-A prospective, observational, single center study. J Clin Anesth. 2020; 62:109743.

7) Hu YB, Zhang YF, Wang H, Ren RJ, Cui HL, Huang WY, Cheng Q, Chen HZ, Wang G. miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson’s disease. Cell Death Dis. 2019; 10(8):589.

8) He X, Yang S, Zhang R, Hou L, Xu J, Hu Y, Xu R, Wang H, Zhang Y. Smilagenin protects dopaminergic neurons in chronic MPTP/probenecid-lesioned Parkinson’s Disease models, Front Cell Neurosci. 2019; 13:18.

9) Wang Y, Xia J, Shen M, Zhou Y, Wu Z, Shi Y, Xu J, Hou L, Zhang R, Qiu Z, Xie Q, Chen H, Zhang Y, Wang H. Effects of BIS-MEP on reversing amyloid plaque deposition and spatial learning and memory impairments in a mouse model of β amyloid peptide- and ibotenic acid-induced Alzheimer’s disease, Front Aging Neurosci. 2019; 11:3.

10) Shi Y, Huang W, Wang Y, Zhang R, Hou L, Xu J, Qiu Z, Xie Q, Chen H, Zhang Y, Wang H. Bis(9)-(-)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice. Transl Neurodegener. 2018; 7:21.

11) Xie Q, Zheng Z, Shao B, Fu W, Xia Z, Li W, Sun J, Zheng W, Zhang W, Sheng W, Zhang Q, Chen H, Wang H, Qiu Z. Pharmacophore-based design and discovery of (-)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis. J Enzyme Inhib Med Chem. 2017; 32(1): 659-671.

12) Wang L, Wang Y, Tian Y, Shang J, Sun X, Chen H, Wang H, Tan W. Design, synthesis, biological evaluation, and molecular modeling studies of chalcone-rivastigmine hybrids as cholinesterase inhibitors. Bioorg Med Chem. 2017; 25(1): 360-371.


【申請和授權(quán)發(fā)明專利】

(1) 專利申請人:王昊,,陳紅專,,宋成寰,張永芳,,黃婉瑩,,徐見容,環(huán)狀 RNA Cwc27 下調(diào)劑在制備預(yù)防和/或治療阿爾茨海默病的藥物中的應(yīng)用,,2020.09.09,,中國,申請?zhí)枺?/span>202010941548.1

(2) 申請人:邱衛(wèi)東,、魯靜文,、王昊、唐鵬,、郭捷,、黃征,、王強民,基于深度學習的抗老年癡呆藥物有效性預(yù)測方法,,2020.04.28,,中國,申請?zhí)枺?/span>CN202010347311.0

(3) 王昊,,王剛,,任汝靜,陳紅專,,胡勇博,,徐見容,張永芳,,張瑞,,侯麗娜,趙蘭雪,,黃婉瑩,,microRNA-425及其類似物作為阿爾茨海默病治療的核苷酸藥物的應(yīng)用,2019.04.22,,中國,,申請?zhí)枺?/span>201910138707.1

(4) 王昊,徐見容,,陳紅專,,胡夢薇,趙蘭雪,,侯麗娜,,王宇,李苗苗,,黃婉瑩,,一種基于抗體的乙酰膽堿酯酶芯片固定方法及其在小分子抑制劑研發(fā)中的應(yīng)用,2018.08.16,,中國,,申請?zhí)枺?/span>201810935936.1

(5) 陳紅專,王昊,,徐見容,,侯麗娜,王宇,,趙恒毅,,鄭兆浠,史玉歡. 作為毒蕈堿受體M1亞型調(diào)節(jié)劑的多肽及其制備方法和用途,2017.12.05,,中國,,專利號:ZL201510391036.1

(6) 謝瓊,史震寰,,邵黎明,,王昊,陳紅專,,仇綴百,,陳益宜,鄭兆浠,,左旋美普他酚茚酮衍生物和/或其鹽類及其制備方法和用途,,2016.6.1,中國,,專利號:CN201410620909.7

(7) Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Hao Wang, Zheng Xia, Meiyan Lu, Xinghai Wang. Meptazinol biligand derivatives and/or their salts, preparation method and uses thereof. 2015.9.23, 歐盟, 專利號:EP2048134 B1

(8) Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Hao Wang, Zheng Xia, Meiyan Lu, Xinghai Wang. Bivalent (-)-meptazinol compounds and/or their salts, and their preparation and futilization. 2012.7.31, 美國, 專利號:US8232270 B2

(9) 仇綴百,,謝瓊,陳紅專,,王昊,,夏錚,盧美艷,,王星海. 二価()-メプタジノール化合物と/或いはモの塩及び製造方法と用途. 2012.10.26,,日本,專利號:JP5118696B2

(10) 仇綴百,,謝瓊,,陳紅專,王昊,,夏錚,,盧美艷,王星海,,(-)-美普他酚雙配基衍生物和/或其鹽類及其制備方法和用途,,2007.7.24,中國,,專利號:PCT/CN2007/002243

(11) 仇綴百,謝瓊,,陳紅專,,王昊,盧美艷,,王星海,,(-)-美普他酚雙配基衍生物和/或其鹽類及其制備方法和用途,2006.7.27,中國,,專利號:CN200610029477.8