【論文與專著】 1) Song C, Shi J, Zhang P, Zhang Y, Xu J, Zhao L, Zhang R, Wang H, Chen H. Immunotherapy for Alzheimer's disease: targeting β-amyloid and beyond. Transl Neurodegener. 2022 Mar 18;11(1):18. 2) Song C, Zhang YF, Huang WY, Shi JY, Huang Q, Jiang MJ, Qiu Y, Wang T, Chen HZ, Wang H. Circular RNA Cwc27 contributes to Alzheimer’s disease pathogenesis by repressing Pur-α activity. Cell Death Differ. 2022, 29(2):393-406. 3) Hu YB, Zhang YF, Ren RJ, Dammer EB, Xie XY, Chen SW, Huang Q, Huang WY, Zhang R, Chen HZ, Wang H, Gang Wang. microRNA-425 loss mediates amyloid plaque microenvironment heterogeneity and promotes neurodegenerative pathologies. Aging Cell. 2021, 20(10):e13454. 4) Song C, Shi J, Xu J, Zhao L, Zhang Y, Huang W, Qiu Y, Zhang R, Chen H, Wang H. Post-transcriptional regulation of α7 nAChR expression by miR-98-5p modulates cognition and neuroinflammation in an animal model of Alzheimer's disease. FASEB J. 2021; 35(6):e21658. 5) Zhang Q, Song Q, Gu X, Zheng M, Wang A, Jiang G, Huang M, Chen H, Qiu Y, Bo B, Tong S, Shao R, Li B, Wang G, Wang H, Hu Y, Chen H, Gao X. Multifunctional nanostructure RAP-RL rescues Alzheimer's cognitive deficits through remodeling the neurovascular unit. Adv Sci (Weinh). 2020; 8(2):2001918. 6) Chen L, Zhang S, Tian W, Huang L, Jiang X, Chen X, Wang H, Su D. Cerebral spinal fluid cholinergic biomarkers predict postoperative cognitive dysfunction in aged patients-A prospective, observational, single center study. J Clin Anesth. 2020; 62:109743. 7) Hu YB, Zhang YF, Wang H, Ren RJ, Cui HL, Huang WY, Cheng Q, Chen HZ, Wang G. miR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson’s disease. Cell Death Dis. 2019; 10(8):589. 8) He X, Yang S, Zhang R, Hou L, Xu J, Hu Y, Xu R, Wang H, Zhang Y. Smilagenin protects dopaminergic neurons in chronic MPTP/probenecid-lesioned Parkinson’s Disease models, Front Cell Neurosci. 2019; 13:18. 9) Wang Y, Xia J, Shen M, Zhou Y, Wu Z, Shi Y, Xu J, Hou L, Zhang R, Qiu Z, Xie Q, Chen H, Zhang Y, Wang H. Effects of BIS-MEP on reversing amyloid plaque deposition and spatial learning and memory impairments in a mouse model of β amyloid peptide- and ibotenic acid-induced Alzheimer’s disease, Front Aging Neurosci. 2019; 11:3. 10) Shi Y, Huang W, Wang Y, Zhang R, Hou L, Xu J, Qiu Z, Xie Q, Chen H, Zhang Y, Wang H. Bis(9)-(-)-Meptazinol, a novel dual-binding AChE inhibitor, rescues cognitive deficits and pathological changes in APP/PS1 transgenic mice. Transl Neurodegener. 2018; 7:21. 11) Xie Q, Zheng Z, Shao B, Fu W, Xia Z, Li W, Sun J, Zheng W, Zhang W, Sheng W, Zhang Q, Chen H, Wang H, Qiu Z. Pharmacophore-based design and discovery of (-)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis. J Enzyme Inhib Med Chem. 2017; 32(1): 659-671. 12) Wang L, Wang Y, Tian Y, Shang J, Sun X, Chen H, Wang H, Tan W. Design, synthesis, biological evaluation, and molecular modeling studies of chalcone-rivastigmine hybrids as cholinesterase inhibitors. Bioorg Med Chem. 2017; 25(1): 360-371.
【申請和授權(quán)發(fā)明專利】 (1) 專利申請人:王昊,,陳紅專,,宋成寰,張永芳,,黃婉瑩,,徐見容,環(huán)狀 RNA Cwc27 下調(diào)劑在制備預(yù)防和/或治療阿爾茨海默病的藥物中的應(yīng)用,,2020.09.09,,中國,申請?zhí)枺?/span>202010941548.1 (2) 申請人:邱衛(wèi)東,、魯靜文,、王昊、唐鵬,、郭捷,、黃征,、王強民,基于深度學習的抗老年癡呆藥物有效性預(yù)測方法,,2020.04.28,,中國,申請?zhí)枺?/span>CN202010347311.0 (3) 王昊,,王剛,,任汝靜,陳紅專,,胡勇博,,徐見容,張永芳,,張瑞,,侯麗娜,趙蘭雪,,黃婉瑩,,microRNA-425及其類似物作為阿爾茨海默病治療的核苷酸藥物的應(yīng)用,2019.04.22,,中國,,申請?zhí)枺?/span>201910138707.1 (4) 王昊,徐見容,,陳紅專,,胡夢薇,趙蘭雪,,侯麗娜,,王宇,李苗苗,,黃婉瑩,,一種基于抗體的乙酰膽堿酯酶芯片固定方法及其在小分子抑制劑研發(fā)中的應(yīng)用,2018.08.16,,中國,,申請?zhí)枺?/span>201810935936.1 (5) 陳紅專,王昊,,徐見容,,侯麗娜,王宇,,趙恒毅,,鄭兆浠,史玉歡. 作為毒蕈堿受體M1亞型調(diào)節(jié)劑的多肽及其制備方法和用途,2017.12.05,,中國,,專利號:ZL201510391036.1 (6) 謝瓊,史震寰,,邵黎明,,王昊,陳紅專,,仇綴百,,陳益宜,鄭兆浠,,左旋美普他酚茚酮衍生物和/或其鹽類及其制備方法和用途,,2016.6.1,中國,,專利號:CN201410620909.7 (7) Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Hao Wang, Zheng Xia, Meiyan Lu, Xinghai Wang. Meptazinol biligand derivatives and/or their salts, preparation method and uses thereof. 2015.9.23, 歐盟, 專利號:EP2048134 B1 (8) Zhuibai Qiu, Qiong Xie, Hongzhuan Chen, Hao Wang, Zheng Xia, Meiyan Lu, Xinghai Wang. Bivalent (-)-meptazinol compounds and/or their salts, and their preparation and futilization. 2012.7.31, 美國, 專利號:US8232270 B2 (9) 仇綴百,,謝瓊,陳紅專,,王昊,,夏錚,盧美艷,,王星海. 二価(─)-メプタジノール化合物と/或いはモの塩及び製造方法と用途. 2012.10.26,,日本,專利號:JP5118696B2 (10) 仇綴百,,謝瓊,,陳紅專,王昊,,夏錚,,盧美艷,王星海,,(-)-美普他酚雙配基衍生物和/或其鹽類及其制備方法和用途,,2007.7.24,中國,,專利號:PCT/CN2007/002243 (11) 仇綴百,謝瓊,,陳紅專,,王昊,盧美艷,,王星海,,(-)-美普他酚雙配基衍生物和/或其鹽類及其制備方法和用途,2006.7.27,中國,,專利號:CN200610029477.8
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