2011年10月9日上午,，上海交通大學(xué)醫(yī)學(xué)院檢驗(yàn)系有幸邀請到了美國康奈爾大學(xué)錢書兵博士,，為09級本科學(xué)生講授了一堂特殊的分子生物學(xué)的課。錢書兵博士結(jié)合學(xué)生的實(shí)際情況,，以英文為主,，中文為輔的形式,，由淺入深的介紹了分子生物學(xué)的基本原理、常用的實(shí)驗(yàn)技術(shù)和科研思路,。整堂課氣氛活躍,，妙趣橫生，學(xué)生們表現(xiàn)出了極高的興趣,，均表示獲益良多,。
Shu-Bing Qian, Ph.D.
http://qian.human.cornell.edu/index.htm
EDUCATION
2004 – 2006 PostDoc University of North Carolina at Chapel Hill Cell Biology
2000 – 2004 PostDoc National Institutes of Health, NIAID Cell Biology
1997 – 2000 Ph.D. Shanghai Jiaotong University Biochemistry
1994 – 1997 M.Sc. Shanghai Jiaotong University Molecular Biology
ACADEMIC APPOINTMENTS
2008 – present Assistant Professor
Division of Nutritional Sciences, Cornell University, Ithaca, NY
2006 – 2008 Research Assistant Professor
Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC
2004 – 2006 Research Fellow
Carolina Cardiovascular Biology Center, University of North
Carolina, Chapel Hill, NC
2000 – 2004 Visiting Fellow
Cell Biology Section, Laboratory of Viral Diseases, NIAID, NIH,
Bethesda, MD
1994 – 2000 Research Assistant
Department of Biochemistry & Molecular Biology, Shanghai Jiaotong
University, Shanghai,P.R.China
AWARDS AND HONORS
2005 Gordon Research Conference Travel Awards, Gordon Research Conferences
2003 NIH Fellows Award for Research Excellence (FARE2004)
2002 NIH Fellows Award for Research Excellence (FARE2003)
2000 Young Scientist Travel Fellowship, the Biochemical Society, FEBS, IUBMB
PUBLICATIONS(2006-2011)
- Conn CS, and Qian SB. Invited review: Nutrient signaling in protein homeostasis. Cell Cycle 2011; 10(12):1940-7QQ QQ
- Sun J, Conn CS, Han Y, Yeung V, and Qian SB. PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 mRNA translation. J Biol Chem 2011 ; 286(8):6791-800
- Qian SB, Zhang X, Sun J, Bennink JR, Yewdell JW, Patterson C. mTORC1 links protein quality and quantity control by sensing chaperone availability. J Biol Chem 2010 ; 285
- Qian SB, Waldren L, Choudhary N, Klevit RE, Chazin WJ, Patterson C. Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer. J Biol Chem 2009 ; 284(39):26797-802
- McDonough H, Charles PC, Hilliard EG, Qian SB, Min JN, Portbury AL, Cyr DM, Patterson C. Stress-dependent chip/DAXX interaction suppresses the p53 apoptotic program. J Biol Chem 2009 ; 284(31): 20649-59
- Xia T , Dimitropoulou C , Zeng J , Antonova GN , Snead C , Venema RC , Fulton D , Qian SB , Patterson C , Papapetropoulos A , Catravas JD . Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase. Am J Physiol Heart Circ Physiol 2007; 293:H3080-3087
- Qian SB , McDonough H , Boellmann F , Cyr DM , Patterson C . CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70. Nature 2006 ; 440: 551-555
- Qian SB , Reits E, Neefjes J, Deslich JM, Bennink JR, and Yewdell JW. Tight linkage between translation and MHC-class I peptide ligand generation implies specialized antigen processing for defective ribosomal products. J Immunol 2006 ; 177: 227-233
- Qian SB , P rinciotta MF , Bennink JR, Yewdell JW. Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control. J Biol Chem 2006 ; 281(1):392-400
