全球健康學(xué)院
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全球健康學(xué)院
當(dāng)前的位置是： 首頁 >> 學(xué)院概況 >> 組織架構(gòu) >> 動(dòng)物健康與食品安全系
從果子貍來源的SARS病毒,、在中國(guó)大陸快速蔓延防控依然嚴(yán)峻的非洲豬瘟,、到當(dāng)前正在肆虐的COVID-19，讓我們充分意識(shí)到保障動(dòng)物健康和動(dòng)物源性食品安全,，不但與人民群眾身體健康息息相關(guān),，還關(guān)乎國(guó)家生物,、生態(tài)環(huán)境和公共衛(wèi)生安全。“健康動(dòng)物-健康食品-健康人類”三者已然成為一個(gè)密不可分的整體,。正是基于“One World, One Health”這一全健康理念,，本系依托崇明研究基地，聚焦“動(dòng)物健康”和“動(dòng)物源性食品安全”兩大核心,，對(duì)豬牛羊等大動(dòng)物,、雞鴨鴿等禽類、魚蝦蟹等水產(chǎn)養(yǎng)殖動(dòng)物、以及遷徙候鳥等野生動(dòng)物全覆蓋,，重點(diǎn)圍繞重要?jiǎng)游镆卟》揽?、新發(fā)再發(fā)人獸共患病控制、動(dòng)物源性耐藥菌和耐藥基因傳播機(jī)制,、動(dòng)物及相關(guān)食品病原體快檢和保障制品安全新技術(shù),、噬菌體等新型減抗綠色生物制劑的開發(fā)與利用，確保“從農(nóng)場(chǎng)到餐桌”,，全產(chǎn)業(yè)鏈動(dòng)物及食品安全管控和健康有序發(fā)展,，為我國(guó)畜禽業(yè)的持續(xù)健康發(fā)展和食品安全提供強(qiáng)有力的科技支撐。
人員：郭曉奎,、沈玉娟,、朱泳璋、劉暢,、艾琳、董珂,、劉浩東,、李敏
項(xiàng)目資助情況
Project funding
全球健康學(xué)院2021年度科技創(chuàng)新項(xiàng)目：基于宏基因組學(xué)方法監(jiān)測(cè)崇明島優(yōu)勢(shì)水產(chǎn)養(yǎng)殖動(dòng)物病原譜流行趨勢(shì)（SGHKJCX20221-01）
Metagenomic-based surveillance pipeline for investigating basic pathogen profiles of predominant aquaculture animals in Chongming Island.
國(guó)家自然科學(xué)基金面上項(xiàng)目：耐藥肺炎克雷伯菌對(duì)靶向保守受體噬菌體雞尾酒制劑的耐受突變機(jī)制及適應(yīng)性代價(jià)研究（3217010039）
代表性論文
Selected Publications
Li T, Lyu L, Zhang Y, Dong K, Li Q, Guo X, Zhu Y. A newly isolated E. thailandicus strain d5B with exclusively antimicrobial activity against C. difficile might be a novel therapy for controlling CDI. Genomics. 2021 Jan;113(1 Pt 2):475-483. doi: 10.1016/j.ygeno.2020.09.032. Epub 2020 Sep 18. PMID: 32956846.
Feng T, Leptihn S, Dong K, Loh B, Zhang Y, Stefan MI, Li M, Guo X, Cui Z. JD419, a Staphylococcus aureus Phage With a Unique Morphology and Broad Host Range. Front Microbiol. 2021 Apr 22;12:602902. doi: 10.3389/fmicb.2021.602902. PMID: 33967969; PMCID: PMC8100676.
Wu N, Dai J, Guo M, Li J, Zhou X, Li F, Gao Y, Qu H, Lu H, Jin J, Li T, Shi L, Wu Q, Tan R, Zhu M, Yang L, Ling Y, Xing S, Zhang J, Yao B, Le S, Gu J, Qin J, Li J, Cheng M, Tan D, Li L, Zhang Y, Zhu Z, Cai J, Song Z, Guo X, Chen LK, Zhu T. Pre-optimized phage therapy on secondary Acinetobacter baumannii infection in four critical COVID-19 patients. Emerg Microbes Infect. 2021 Dec;10(1):612-618. doi: 10.1080/22221751.2021.1902754. PMID: 33703996; PMCID: PMC8032346.
Wang Y, Fan X, Du L, Liu B, Xiao H, Zhang Y, Wu Y, Liu F, Chang YF, Guo X, He P. Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages. Emerg Microbes Infect. 2021 Dec;10(1):939-953. doi: 10.1080/22221751.2021.1925160. PMID: 33929941; PMCID: PMC8153709.
Fu X, Lyu L, Wang Y, Zhang Y, Guo X, Chen Q, Liu C. Safety assessment and probiotic characteristics of Enterococcus lactis JDM1. Microb Pathog. 2022 Jan 1;163:105380. doi: 10.1016/j.micpath.2021.105380. Epub ahead of print. PMID: 34979271.
Lyu L, Feng R, Zhang M, Gong Q, Liao Y, Zhou Y, Guo X, Su B, Dorsett Y, Chen L. Large scale sub-genomic RNA profiling suggests novel mechanism in coronavirus gene regulation and host adaption. Nucleic Acids Research 2022 accepted.