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 Zhang-Peng Chen, Ph.D., Principle Investigator

Email[email protected]; [email protected]

ResearchNeuroimmune mechanism and intervention in epilepsy

 

Education

Ph.D., 2013-2018, Mentor: Dr. Jing-Ning Zhu, Nanjing University

B.S., 2009-2013, , Bengbu Medical University, China

 

Experience

2024-01 - Now  Investigator, Shanghai Jiao Tong University, Songjiang Research Institute

2023.07-2023.12  Associate research fellow, Nanjing University

2020.12-2023.07  Assistant research fellow, Nanjing University

2018.07-2020.12   Postdoctoral research fellow, Nanjing University

 



Zhang-Peng Chen

     Epilepsy is an important neurological disease with a prevalence of about 1% in the population. There are nearly 10 million epilepsy patients in China, of which drug-resistant epilepsy (DRE) patients account for 30%, and there is no effective clinical drug. Our group use cutting-edge technologies in neuroscience, such as in vivo electroencephalography, immunomagnetic cell sorting, two-photon calcium imaging, fiber optic calcium recording and patch clamp, to explore the mechanism of the development of important neurological diseases such as epilepsy. We focus on the mechanism of interaction between neuron and glial cell, immune cell and glial cell in temporal lobe epilepsy and other neurological disease accompanied with epilepsy symptom (Nat Neurosci, 2023; Nat Neurosci, 2024, revised; Neuron, under review). Specifically, we focus on the following three aspects:

    1) Study the interaction between glial cells and neurons in temporal lobe epilepsy;

    2) Carry out the mechanism of interaction between peripheral immune cells and central nervous cells (glial cells) in epileptic brain ( in temporal lobe epilepsy and other neurological disease accompanied with epilepsy symptom);

    3) The external environmental stimulus can induce epilepsy, and its mechanism is not clear. We focus on the neural circuit mechanism of external environmental stimulus such as sound and light induced epilepsy.