E-Mail：[email protected]

Research interests: 1. Central regulatory mechanisms of anorexia nervosa; 2. Molecular mechanisms of central inflammation and metabolic disorders induced by the obesity gene MC4R

Educational Experience：

2016.09-2021.06 College of Life Science and Technology, Tongji University, Biology, Ph.D.

2012.09-2016.06 College of Life Science and Technology, Guangxi University, Biological Engineering, Bachelor

Work Experience:

2023.10 to Present Associate Researcher, Songjiang Research Institute, School of Medicine, Shanghai Jiaotong University, China

2021.09-2023.10 Postdoctoral Fellow, Basic Medicine, School of Medicine, Shanghai Jiaotong University, China

Representative papers：

1.    Meng Wang*, Guangmin Zheng*, Xiaoyong Hu*, Feng Tian*, Tuo Li, Zheng Zhang, Kan Gong, Shiwei Chen, Lin Yuan, Yu Qi, Lin Li, Daofu Cheng, Liu Liu, Fuqiang Liu, Yujing Sun, Xiangdong Fang, Ruxing Zhao, Bing Liu9, Chao Zhang. Advanced Science. 2025 Jan. In Press. DOI:10.1002/advs.202413493. IF=14.3. Q1

2.    Meng Wang, Yong Han, Chao Zhang. Noval insights and therapeutic strategies for tumor-induced kidney pathologies. Journal of Experimental & Clinical Cancer Research. 2024 Oct 19;43(1):289. IF=11.4. Q1

3.    Meng Wang*, Tao Zan*, Chengang Fan, Zhouxiao Li, Danru Wang, Qingfeng Li, Chao Zhang. Advances in GPCR-targeted drug development in dermatology. Trends in Pharmacological Sciences. 2024 Aug;45(8):678-690. IF=13.9. Q1

4.    Jihong Zheng*, Wenqi Song*, Yihang Zhou*, Xuan Li*, Meng Wang (Co-Corresponding Author), Chao Zhang. Cross-species single-cell landscape of vertebrate pineal gland. Journal of Pineal Research. 2024 Jan;76(1):e12927. IF=15.221. Q1

5.    Meng Wang*, Jianjun Lyu, Chao Zhang. Single transmembrane GPCR modulating proteins: neither single nor simple, Protein & Cell. 2023; pwad035. IF=21.1. Q1

6.    Meng Wang*, Xiaozhu Wang*, Bopei Jiang, Yue Zhai, Jihong Zheng, Liu Yang, Xiaolu Tai, Yunpeng Li, Shaliu Fu, Jing Xu, Xiaowei Lei, Zhe Kuang, Cong Zhang, Xuanxuan Bai, Mingyu Li, Tao Zan, Shen Qu, Qingfeng Li, Chao Zhang. Identification of MRAP protein family as broad‐spectrum GPCR Modulators, Clinical and Translational Medicine. 2022 Nov;12(11):e1091. IF=11.492. Q1

7.    Meng Wang*, Yue Zhai, Xiaowei Lei, Jing Xu, Bopei Jiang, Zhe Kuang, Cong Zhang, Shangyun Liu, Shan Bian, Xiao-Mei Yang, Tao Zan, Li-Na Jin, Qingfeng Li, Chao Zhang. Determination of the interaction and pharmacological modulation of MCHR1 signaling by C terminus of MRAP2 protein, Frontiers in Endocrinology. 2022, 13: 848728. IF=6.055. Q1

8.    Meng Wang*, Jing Xu*, Xiaowei Lei*, Cong Zhang, Shang-Yun Liu, Li-Na Jin, Chao Zhang. Selective Interactions of Mouse Melanocortin Receptor Accessory Proteins with Somatostatin Receptors, Cells. 2022, 11(2): 267. IF=7.666. Q2

9.    Meng Wang*, Yue Zhai, Liumei Lu, Cong Zhang, Na Li, Song Xue, Daofu Cheng, Shaliu Fu, Qi Liu, Chao Zhang. Elucidation of the dimeric interplay of dual MRAP2 proteins in the zebrafish, Journal of Cellular Physiology. 2021, 236(9): 6472-6480. IF=6.513. Q1

10.  Meng Wang*, Linyu Pi*, Xiaowei Lei*, Lei Li, Jing Xu, Zhe Kuang, Cong Zhang, Liang Li, Chao Zhang. Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer, Frontiers in Endocrinology. 2021, 12: 750797. IF=6.055. Q1

Honors and Awards：

2022 Shanghai Super Postdoctoral Incentive Program;

2022 First Prize of Science and Technology Award of Chinese Society of Rehabilitation Medicine (Research on molecular pathways of wound healing and functional reconstruction after limb transplantation and application of related rehabilitation techniques);

2016.09-2021.06 Guanghua Scholarship, Excellent Student of Tongji University, etc.

2012.09-2016.06 National Scholarship, Presidential Scholarship, Outstanding Graduate of the Autonomous Region, Outstanding Student Leader of the Autonomous Region, etc. 

Projects chaired in the last five years：

1.    Study on the Physiological Mechanism of Obesity Regulation in the Ventromedial Hypothalamus (VMH) by the cAMP Signaling Pathway Mediated by GLP1R-Associated Protein MRAP2, National Natural Science Foundation of China, Youth Project, 82400980, Jan 2025 - Dec 2027, 300,000 RMB, Host

2.    Clinical Research Youth Project of the Shanghai Health Commission, 20244Y0184, Oct 2024 - Sep 2027, 50,000 RMB, Host

3.    Spatiotemporal Network Regulation Mechanism of Pituitary Hormones on Glucose and Lipid Metabolism and Clinical Translation Strategies, Key Pituitary Hormones in Metabolic Diseases, Screening of Interventional Pituitary Hormones and Small Molecule Drug Lead Compounds, Major Project of the Ministry of Science and Technology, "Cancer, Cardiovascular and Cerebrovascular Diseases, Respiratory and Metabolic Diseases Prevention and Treatment Research" under the 2030 Innovation Program, SQ2023AAA031917, Dec 2023 - Nov 2027, 1.44 million RMB, Core Research Team Member

4.    Single-cell sequencing reveals different molecular mechanisms of obesity genes Leptin and MC4R mediating central neuroinflammation, The 72nd batch of postdoctoral top-level project second-class funding, 2022M722127, 2022.11-2023.11, 80,000 RMB concluded, Host