余健秀 研究員
蛋白質(zhì)修飾與RNA修飾研究組
電話：021-54660870
郵箱： [email protected]
[email protected]
研究方向
1．蛋白質(zhì)修飾調(diào)控腫瘤發(fā)生發(fā)展
2．蛋白質(zhì)修飾調(diào)控miRNA的生物合成與作用效率
3．RNA降解機(jī)制
4．蛋白質(zhì)修飾調(diào)控RNA修飾及其功能
個(gè)人簡(jiǎn)歷
現(xiàn)任上海交通大學(xué)醫(yī)學(xué)院PI、特聘教授、博士生導(dǎo)師、生物化學(xué)與分子細(xì)胞學(xué)系科研副主任。
1990年-華南農(nóng)業(yè)大學(xué)學(xué)士
1996年-中山大學(xué)理學(xué)碩士
2000年-中山大學(xué)理學(xué)博士
2000年-2002年中山大學(xué)生命科學(xué)學(xué)院副教授
2002年-2007年美國(guó)Sanford-Burnham Medical Research Institute/UCSD博士后
2007年-2008年美國(guó)Sanford-Burnham Medical Research Institute/UCSD, Staff Scientist
2008年-2009年美國(guó)紐約大學(xué)Langone Medical Center研究助理教授
2009年-至今上海交通大學(xué)醫(yī)學(xué)院PI、研究員
2016年-至今上海交通大學(xué)醫(yī)學(xué)院特聘教授
2018年-至今生物化學(xué)與分子細(xì)胞學(xué)系科研副主任
2018年-至今擔(dān)任中國(guó)抗癌協(xié)會(huì)腫瘤標(biāo)志專業(yè)委員會(huì)“非編碼與腫瘤研究”專家委員會(huì)副組長(zhǎng)
科研項(xiàng)目
1．國(guó)家重點(diǎn)研發(fā)計(jì)劃政府間國(guó)際科技創(chuàng)新合作項(xiàng)目，惡性腫瘤發(fā)生發(fā)展中關(guān)鍵表觀遺傳與轉(zhuǎn)錄調(diào)控因子的蛋白質(zhì)修飾及其功能，2019YFE0110600，主持人，2020.12~2023.11。
2．國(guó)家自然科學(xué)基金重點(diǎn)項(xiàng)目，PTEN在DNA損傷修復(fù)中介導(dǎo)組蛋白H2A/H3修飾調(diào)控前列腺癌發(fā)生發(fā)展， 81630075，主持人，2017.01~2021.12。
3．國(guó)家自然科學(xué)基金面上項(xiàng)目，Ago2乙酰化在miRNA途徑中的功能與機(jī)制，31671345，主持人，2017.01~2020.12。
代表性論文 (*corresponding author)
1. Deng R, Guo Y, Li L, He J, Qiang Z, Zhang H, Chen R, Wang Y, Zhao X*, Yu J*. BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN. Mol Oncol., 2020 Nov 5. https://doi.org/10.1002/1878-0261.12844.
2. Zhao X, Wang Y, He J, Deng R, Huang X, Guo Y, Li L, Xie R*, Yu J*. LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells. Mol Carcinog. 2020 Oct;59(10):1174-1187.
3. Dou J, Zhang H, Chen R, Shu Z, Yuan H, Zhao X, Wang Y, Huang J, Zhou A*, Yu J*. SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells. Mol Oncol. 2020 Sep;14(9):2288-2312.
4. Lin R, Zhan M, Yang L, Wang H, Shen H, Huang S, Huang X, Xu S, Zhang Z, Li W, Liu Q, Shi Y, Chen W, Yu J*, Wang J*. Deoxycholic acid modulates the progression of gallbladder cancer through N6-methyladenosine-dependent microRNA maturation. Oncogene. 2020 Jun; 39(26):4983-5000.
5. Liu T, Zhang H, Fang J, Yang Z, Chen R, Wang Y, Zhao X, Ge S, Yu J*, Huang J*. AGO2 phosphorylation by c-Src kinase promotes tumorigenesis. Neoplasia. 2020 Mar;22(3):129-141.
6. Cui N, Liu T, Guo Y, Dou J, Yang Q, Zhang H, Chen R, Wang Y, Zhao X, Yu J*, Huang J*. SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function. Neoplasia. 2019 May 21; 21(7):676-688.
7. Zhang H, Wang Y, Dou J, Guo Y, He J, Li L, Liu X, Chen R, Deng R, Huang J, Xie R, Zhao X*, Yu J*. Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis. Oncogene. 2019 Feb; 38(9):1410-1431.
8. Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, Jiang B, Xu M, Cheng J, Chen GQ, Zhao X*, Yu J*.SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function. Nucleic Acids Res. 2018, 46(10) 5195-5208.
9. Yuan H, Deng R, Zhao X, Chen R, Hou G, Zhang H, Wang Y, Xu M, Jiang B*, Yu J*. SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis. Mol Cancer. 2017 Oct 11; 16(1):157.
10. Wang J, Deng R, Cui N, Zhang H, Liu T, Dou J, Zhao X, Chen R, Wang Y, Yu J*, Huang J*. Src SUMOylation Inhibits Tumor Growth Via Decreasing FAK Y925 Phosphorylation. Neoplasia. 2017 Oct 22; 19(12):961-971.
11. Jiang H, Deng R, Yang X, Shang J, Lu S, Zhao Y, Song K, Liu X, Zhang Q, Chen Y, Chinn YE, Wu G, Li J, Chen G, Yu J*, Zhang J*. Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nature Chem Biol. 2017, 13(9):994-1001.
12. Zhao X, Deng R, Wang Y, Zhang H, Dou J, Li L, Du Y, Chen R, Cheng J, Yu J*. Twist1/Dnmt3a and miR186 establish a regulatory circuit that controls inflammation-associated prostate cancer progression. Oncogenesis. 2017, 6(4): e315.
13. Zhu C, Chen C, Chen R, Deng R, Zhao X, Zhang H, Duo J, Chen Q, Jin H, Wang Y, Huang J, Xu M*, Yu J*. K259-SUMOylation of DGCR8 promoted by p14ARF exerts a tumor-suppressive function. J Mol Cell Biol. 2016 Oct 07, 8(5):456-458.
14. Chen C, Zhu C, Huang J, Zhao X, Deng R, Zhang H, Dou J, Chen Q, Xu M, Yuan H, Wang Y, Yu J*. SUMOylation of TARBP2 regulates miRNA/siRNA efficiency. Nature Communications. 2015, 6:8899.
15. Lu S, Deng R, Jiang H, Song H, Li S, Shen Q, Huang W, Nussinov R, Yu J*, Zhang J*. The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation. Structure. 2015, 23(9):1725-34.
16. Zhu C, Chen C, Huang J, Zhang H, Zhao X, Deng R, Dou J, Jin H, Chen R, Xu M, Chen Q, Wang Y, Yu J*. SUMOylation at K707 of DGCR8 controls direct function of primary microRNA. Nucleic Acids Res. 2015, 43(16):7945-60.
17. Chen Q, Zhao X, Zhang H, Yuan H, Zhu M, Sun Q, Lai X, Wang Y, Huang J, Yan J, Yu J*. MiR-130b suppresses prostate cancer metastasis through down-regulation of MMP2. Mol Carcinogen. 2015, 54(11):1292-300.
18. Lai X, Chen Q, Zhu C, Deng R, Zhao X, Chen C, Wang Y, Yu J*, Huang J*. Regulation of RPTPα-c-Src signalling pathway by miR-218. FEBS J. 2015, 282(14):2722-34.
19. Sun Q, Zhao X, Liu X, Wang Y, Huang J, Jiang B, Chen Q*, Yu J*.miR-146a functions as a tumor suppressor in prostate cancer by targeting Rac1. Prostate. 2014, 74(16):1613-21.
20. Zhu M, Chen Q, Liu X, Sun Q, Zhao X, Deng R, Wang Y, Huang J, Xu M, Yan J, Yu J*. lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI. FEBS J. 2014, 281:3766-3775.
21. Qu Y, Chen Q, Lai X, Zhu C, Chen C, Zhao X, Deng R, Xu M, Yuan H, Wang Y, Yu J*, Huang J*.SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1. Mol Cancer, 2014, 13(1):95.
22. Liu X, Chen Q, Yan J, Wang Y, Zhu C, Chen C, Zhao X, Xu M, Sun Q, Deng R, Zhang H, Qu Y, Huang J, Jiang B, Yu J*. MiRNA-296-3p-ICAM-1 axis promotes metastasis of prostate cancer by possible enhancing survival of natural killer cell-resistant circulating tumour cells. Cell Death Dis. 2013, 4:e928.
23. Yu J*, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS*. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1 and SH2-tyrosine phosphatase Shp2. J Biol Chem. 2013, 288(6):3823-30.
24. Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J*. SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nature Communications. 2012, 3:911.
25. Liu X, Wang Y, Sun Q, Yan J, Huang J, Zhu S, Yu J*. Identification of microRNA transcriptome involved in human natural killer cell activation. Immunol Lett. 2012, 143(2):208-17.
26. Yu J*, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E*, Mustelin T. PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 2009, 28(1):21-33.
27. Yu J, Baron V, Mercola D, Mustelin T, Adamson ED*. A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells. Cell Death and Differentiation. 2007, 14(3):436-46.
28. Yu J, de Belle I, Liang H, Adamson ED*. Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. Molecular Cell, 2004, 15(1): 83-94.
