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聯(lián)系方式：上海市重慶南路280號上海交通大學醫(yī)學院 E-mail： [email protected] 實驗室人員組成： PI：徐穎潔 助理研究員：于翔 技術(shù)員：殷亞男 博士后：黃瑪莎 研究生：張佳慧，安之音，張宇，曾潔 聯(lián)合培養(yǎng)：夏佳 課題組長主要學習工作經(jīng)歷： 上海第二醫(yī)科大學臨床醫(yī)學七年制，獲醫(yī)學碩士學位 加拿大麥吉爾大學實驗醫(yī)學系，獲博士學位 美國哈佛醫(yī)學院波士頓兒童醫(yī)院，博士后 研究方向與進展： 1、 介導癌癥轉(zhuǎn)移及耐藥的分子靶點發(fā)現(xiàn)、機制探究和靶向治療評估 2、 優(yōu)化mRNA的體外合成與體內(nèi)遞送 3、 研發(fā)基于mRNA的治療應(yīng)用：包括癌癥mRNA疫苗、感染性疾病mRNA疫苗、mRNA的蛋白替代療法在癌癥及其他疾病中的應(yīng)用 代表論文： 1. Zhang J, Li Y, Liu H, Zhang J,Wang J, Xia J, Zhang Y, Yu X, Ma J, Huang M, Wang J, Wang L, Li Q, Cui R, Yang W*, Xu Y*，F(xiàn)eng W*. Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis. J Exp Clin Cancer Res. 2022; 41:24. doi: 10.1186/s13046-022-02242-3(* Co-correspoding author) 2. Xia, J., Zhang, J., Wang, L., Xu, Y., Yang, W., Yu, Y.(2021). Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation. Cell Death Disease 12,833. 3. Zhang, JH; Yin, YN; Wang, JH; Zhang, JJ; Liu, H; Feng, WW; Yang, W; Bruce Zetter; Xu, YJ.(2021).Prohibitin regulates mTOR pathway via the interaction with FKBP8. Frontiers of Medicine 15,448-459 4.杭辰悅,徐山杉,吳其峰,張普昱,張宇,徐穎潔. mRNA 治療及其應(yīng)用前景.(2021).科學通報, Z2期 5.Lu,J;Lu,GL; Tan,SD; Xia, J; Xiong, HL;Yu, XF; Qi, QQ; Yu,X; Li, L; Yu, H; Xia, NS; Zhang, TY*, Xu, YJ*; Lin, JZ*.(2020). A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice.Cell Research 10 ,936-939.(*Co-corresponding author) 6.Islam MA, Xu Y*, Tao W, et al. Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA. Nature Biomedical Engineering. 2018 Nov;2(11):850-864. DOI: 10.1038/s41551-018-0284-0. PMID: 31015614; PMCID: PMC6486184.(*Co-first author) 7.Xu Y, Yang W, Shi J, Zetter BR. Prohibitin 1 regulates tumor cell apoptosis via interaction with X-linked Inhibitor of Apoptosis Protein. J Mol Cell Biol. 2016 Jun; 8(3):282-5. doi: 10.1093/jmcb/mjw018. 8.Zhu X, Xu Y*, Solis LM, Tao W, Wang L, Behrens C, Xu X, Zhao L, Liu D, Wu J, Zhang N, Wistuba II, Farokhzad OC, Zetter BR, Shi J. Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7779-84. (*Co-first author) 9.Shi J, Xu Y*, Xu X, Zhu X, Pridgen E, Wu J, Alexander V, Zetter BR, Farokhzad O. Hybrid Lipid-Polymer Nanoparticles for Sustained siRNA Delivery and Gene Silencing. Nanomedicine. 2014 Jul; 10(5):897-900. doi: 10.1016/j.nano.2014.03.006. (*Co-first author) 10.Xu Y, Bismar TA, Su J, Xu B, Kristiansen G, Varga Z, Teng L, Ingber DE, Mammoto A, Kumar R, Alaoui-Jamali MA. Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med. 2010 Oct 25; 207(11):2421-37. Epub 2010 Oct 11. |
徐穎潔 研究員