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楊文 研究員 聯(lián)系方式：上海市重慶南路280號上海交通大學(xué)醫(yī)學(xué)院 E-mail ：[email protected] 微信公眾號：“線粒體代謝與衰老”（MitoAging）
實驗室人員組成： PI：楊文 助理研究員：鄭媛 技術(shù)員：王潔 博士后：何翔 研究生：李沄，楊崢，侯雨彤，蔡穎 聯(lián)合培養(yǎng)：李薇，閆冉 本科生：蘇俊澄，孫涵
課題組長主要學(xué)習(xí)工作經(jīng)歷： 上海復(fù)旦大學(xué)，學(xué)士學(xué)位 加拿大麥吉爾大學(xué)，獲博士學(xué)位 美國哈佛醫(yī)學(xué)院，博士后 研究方向與進展： 從事線粒體和衰老的分子機制研究，利用蛋白質(zhì)組學(xué)的方法研究線粒體蛋白動態(tài)變化及其與衰老及相關(guān)疾病的關(guān)系。主要關(guān)注衰老和相關(guān)疾病中線粒體蛋白水平修飾（包括乙酰化、琥珀酰化和氧化等）對線粒體功能的調(diào)節(jié)和反向信號傳導(dǎo)的影響。現(xiàn)階段主要包括以下幾個課題方向： 1. 線粒體過氧化物介導(dǎo)的反向信號傳導(dǎo)與衰老和細胞死亡 2. 酮戊二酸脫氫酶特異性伴侶素蛋白的功能及其與疾病的關(guān)系 3. 線粒體-細胞器互作的蛋白網(wǎng)絡(luò) 4. 線粒體代謝與癌癥耐藥 代表論文： 1. Zhang J, Li Y, Liu H, Zhang J,Wang J, Xia J, Zhang Y, Yu X, Ma J, Huang M, Wang J, Wang L, Li Q, Cui R, Yang W*, Xu Y*，F(xiàn)eng W*. Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis. J Exp Clin Cancer Res. 2022; 41:24. doi: 10.1186/s13046-022-02242-3(* Co-correspoding author) 2. Xia, J., Zhang, J., Wang, L., Xu, Y., Yang, W., Yu, Y.(2021). Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation. Cell Death Disease 12,833. 3. Zhang, JH; Yin, YN; Wang, JH; Zhang, JJ; Liu, H; Feng, WW; Yang, W; Bruce Zetter;Xu, YJ.(2021).Prohibitin regulates mTOR pathway via the interaction with FKBP8. Frontiers of Medicine 15,448-459 4. Mao,C., Xu, Y.,Yang, W., Liu, Z.(2021).Genome-wide analysis identify novel germline genetic variations in ADCY1 influencing platinum-based chemotherapy response in non-small cell lung cancer. Acta Pharmaceutica Sinica B. Oct 5. Jing Xu, Jiahui Wang, Xiaoli Wang, Ruoming Tan, Xiaoling Qi, Zhaojun Liu, Hongping Qu, Tingting Pan, Qingyuan Zhan, Yong Zuo* ,Wen Yang* , Jialin Liu*, Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages, Cell death and diseases, 2020 Oct 30;11(10):934. doi: 10.1038/s41419-020-03139-9. 6.Wen Yang et al. Mitochondrial Sirtuins Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks, Introductory Review on Sirtuins in Biology, Aging, and Disease, 2018, Pages 95-115 7.Wen Yang et al. Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-dependent Deacetylation in Response to Membrane Depolarization. Cell， 2016 Nov 3 8.Callista Yee, Wen Yang, and Siegfried Hekimi.: The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell, 2014 May 8;157(4):897-909 9.Hekimi S, Lapointe J, Yang W,: Taking a “good” look at free radicals in the aging process. Trends in Cell Biology, 2011, Jan;67(1):1-8. 10.Yang W and Hekimi S: A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans. PLOS biology. 2010 Dec; 8(12):e1000556 11.Yang W and Hekimi S: Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell. 2010 Jun;9(3):433-47.
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