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實驗室成員： PI：孫序序 教授：楊潔 實驗師：朱慧琴 研究生：劉芳、邊琦、唐宏誼、趙文珍
課題組研究方向： 課題組主要運用基因編輯小鼠模型以及分子細胞生物學(xué)方法探索肝損傷、脂肪肝、肝硬化以及肝癌的發(fā)病機理。目前研究方向： 1. 探索SWI/SNF染色質(zhì)重塑復(fù)合物在肝臟再生、脂肪肝、肝硬化和肝癌中的分子作用機制。 2. 探索免疫治療在肝癌中的作用和分子機制。 3. 利用肝癌類器官培養(yǎng)模型模擬肝癌發(fā)病機理并探索治療新方法。
課題組長孫序序?qū)W習(xí)及工作經(jīng)歷： 山東大學(xué)生物科學(xué)專業(yè)，學(xué)士 上海交通大學(xué)醫(yī)學(xué)院細胞生物學(xué)專業(yè)，博士 上海東方肝膽外科醫(yī)院病理科，研究助理 香港中文大學(xué)中藥研究所，研究助理 美國德克薩斯大學(xué)西南醫(yī)學(xué)中心，博士后
代表論文： 1. Xuxu Sun,* Sam C. Wang,* Yonglong Wei, Xin Luo, Yuemeng Jia, Lin Li, Purva Gopal, Min Zhu, Ibrahim Nassour, Jen-Chieh Chuang, Thomas Maples, Cemre Celen, Liem H. Nguyen, Linwei Wu, Shunjun Fu, Weiping Li, Lijian Hui, Feng Tian, Yuan Ji, Shuyuan Zhang, Mahsa Sorouri, Tae Hyun Hwang, Lynda Letzig, Laura James, Zixi Wang, Adam C. Yopp, Amit G. Singal, Hao Zhu. Arid1a has context-dependent oncogenic and tumor suppressor functions in liver cancer. Cancer Cell 2017, 32 (5), p574–589. 2. Xuxu Sun, Jen-Chieh Chuang, Mohammed Kanchwala, Linwei Wu, Cemre Celen, Lin Li, Hanquan Liang, Shuyuan Zhang, Thomas Maples, Liem H. Nguyen, Sam C. Wang, Robert A.J. Signer, Mahsa Sorouri, Ibrahim Nassour, Xin Liu, Jian Xu, Meng Wu, Yong Zhao, Yi-Chun Kuo, Zhong Wang, Chao Xing, Hao Zhu. Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration. Cell Stem Cell 2016, 18(4):456-466. 3. Shan Yan*, Xuxu Sun*, Binggang Xiang, Hui Cang, Xunlei Kang, Yuying Chen, Hui Li, Guiying Shi, Edward T H Yeh, Beilei Wang, Xiangrui Wang, Jing Yi. Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. EMBO J 2010, 29(22):3773-86. (*Co-first author) 4. Austin Moore,Linwei Wu, Jen‐Chieh Chuang, Xuxu Sun, Xin Luo, Purva Gopal, Lin Li, Cemre Celen, Michael Zimmer, Hao Zhu. Arid1a loss drives non-alcoholic steatohepatitis in mice via epigenetic dysregulation of hepatic lipogenesis and fatty acid oxidation. Hepatology 2018Dec 25. doi: 10.1002/hep.30487 5. Sam C Wang, Ibrahim Nassour, Shu Xiao, Shuyuan Zhang, Xin Luo, Jeon Lee, Lin Li, Xuxu Sun, Liem H Nguyen, Jen-Chieh Chuang, Lan Peng, Scott Daigle, Jeanne Shen, Hao Zhu. SWI/SNF component ARID1A restrains pancreatic neoplasia formation. Gut 2018, 0:1–12. 6. Cemre Celen, Jen-Chieh Chuang, Xin Luo, Nadine Nijem, Angela K Walker, Fei Chen, Shuyuan Zhang, Andrew S Chung, Liem H Nguyen, Ibrahim Nassour, Albert Budhipramono, Xuxu Sun, Levinus A Bok, Meriel McEntagart, Evelien F Gevers, Shari G Birnbaum, Amelia J Eisch, Craig M Powell, Woo-Ping Ge, Gijs WE Santen, Maria Chahrour, and Hao Zhu. Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. eLife 2017; 6: e25730. 7. Kai Yang, Ming Wang, Yuzheng Zhao, Xuxu Sun, Yi Yang, Xie Li, Aiwu Zhou, Huilin Chu, Hu Zhou, Jianrong Xu, Mian Wu, Jie Yang,a, and Jing Yi. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nature Commun. 2016, 7:13599. 8. Chi-Man Koon, Chun-Hay Ko, Xu-Xu Sun, Sandy Wan-Heng Hoi, Jacqueline Chor-Wing Tam, David Wing-Shing Cheung, King-Fai Cheng, Suet-Yee Pang, Wing-Man Lo, Ping Chook, Clara Bik-San Lau, Wai-Yee Chan, Ping-Chung Leung, Timothy Chi-Yui Kwok, Kwok-Pui Fung. Gene Expression Profiling on the Molecular Action of Danshen-Gegen Formula in a Randomized Placebo-Controlled Trial of Postmenopausal Women with Hypercholesterolemia. Evid Based Complement Alternat Med 2013, (2013) 703705 9. Wenming Cong, Hui Dong, Lu Tan, Xuxu Sun, Mengchao Wu. Surgicopathological classification of hepatic space-occupying lesions: a single-center experience with literature review. World J Gastroenterology 2011, 17(19):2372-8. Review Article. 10. Yan Han, Chao Huang, Xuxu Sun, Binggang Xiang, Edward T H Yeh, Yuying Chen, Hui Li, Guiying Shi, Hui Cang, Yueping Sun, Jian Wang, Wei Wang, Fei Gao, Jing Yi. SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem 2010, 285(17): 12906-15 11. Yong Zuo, Binggang Xiang, Jie Yang, Xuxu Sun, Hui Cang, Ying Wang, Jing Yi. Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1. Cell Research 2009, 19(4): 449-57. 12. Chao Huang, Yan Han, Yumei Wang, Xuxu Sun, Shan Yan, Edward T H Yeh, Yuying Chen, Hui Cang, Hui Li, Guiying Shi, Jinke Cheng, Xueming Tang, Jing Yi. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J 2009, 28(18): 2748-62.
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