楊文 研究員
線粒體代謝與衰老研究組
電話：63846590-776492
郵箱：[email protected]
研究方向
從事線粒體和衰老的分子機(jī)制研究，利用蛋白質(zhì)組學(xué)的方法研究線粒體蛋白動(dòng)態(tài)變化及其與衰老及相關(guān)疾病的關(guān)系。主要關(guān)注衰老和相關(guān)疾病中線粒體蛋白水平修飾（包括乙酰化、琥珀酰化和氧化等）對(duì)線粒體功能的調(diào)節(jié)和反向信號(hào)傳導(dǎo)的影響。現(xiàn)階段主要包括以下幾個(gè)課題方向：
1. 線粒體過氧化物介導(dǎo)的反向信號(hào)傳導(dǎo)與衰老和細(xì)胞死亡
2. 酮戊二酸脫氫酶特異性伴侶素蛋白的功能及其與疾病的關(guān)系
3. 線粒體-細(xì)胞器互作的蛋白網(wǎng)絡(luò)
4. 線粒體代謝與癌癥耐藥
個(gè)人簡歷
楊文，博士，博士生導(dǎo)師。2010年獲得加拿大麥吉爾大學(xué)博士學(xué)位，2011-2017年于美國哈佛大學(xué)醫(yī)學(xué)院從事博士后研究。2017年加入生化與分子細(xì)胞生物學(xué)系，擔(dān)任研究員。課題組聚焦線粒體代謝與衰老相關(guān)研究。近年來以第一作者在國際重要學(xué)術(shù)刊物(如Cell, PLOS Biology等)上發(fā)表SCI論文，他引超過700次。曾獲Charles A. King fellowship Award。
科研項(xiàng)目
項(xiàng)目批準(zhǔn)號(hào)：91954120
項(xiàng)目名稱：解析線粒體參與細(xì)胞器互作的蛋白網(wǎng)絡(luò)及分子機(jī)制
項(xiàng)目類別：重大研究計(jì)劃
項(xiàng)目批準(zhǔn)號(hào)：31871430
項(xiàng)目名稱：神經(jīng)細(xì)胞中C3orf23調(diào)控酮戊二酸脫氫酶的作用與機(jī)制研究
項(xiàng)目類別：面上項(xiàng)目
項(xiàng)目批準(zhǔn)號(hào)：2019YFA0508601;
項(xiàng)目名稱：蛋白質(zhì)機(jī)器與生命過程調(diào)控
項(xiàng)目類別：重點(diǎn)專項(xiàng)
論文與專著
1. Zhang J, Li Y, Liu H, Zhang J, Wang J, Xia J, Zhang Y, Yu X, Ma J, Huang M, Wang L, Li Q, Cui R, Yang W*, Xu Y*, Feng W*. Genome-wide CRISPR/Cas 9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis. J Exp Clin Cancer Res. 2022;41:24. doi:10.1186/s13046-022-02242-3(*Co-corresponding author)
2. Xia, J., Zhang, J., Wang, L., Xu, Y., Yang, W., Yu, Y.(2021). Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation. Cell Death Disease 12,833.
3. Zhang, JH; Yin, YN; Wang, JH; Zhang, JJ; Liu, H; Feng, WW; Yang, W; Bruce Zetter;Xu, YJ.(2021).Prohibitin regulates mTOR pathway via the interaction with FKBP8. Frontiers of Medicine 15,448-459
4. Mao,C., Xu, Y.,Yang, W., Liu, Z.(2021).Genome-wide analysis identify novel germline genetic variations in ADCY1 influencing platinum-based chemotherapy response in non-small cell lung cancer. Acta Pharmaceutica Sinica B. Oct
5. Jing Xu, Jiahui Wang, Xiaoli Wang, Ruoming Tan, Xiaoling Qi, Zhaojun Liu, Hongping Qu, Tingting Pan, Qingyuan Zhan, Yong Zuo* ,Wen Yang* , Jialin Liu*, Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages, Cell death and diseases, 2020 Oct 30;11(10):934. doi: 10.1038/s41419-020-03139-9.3.
6.Kai Xin, Xinxing Li, Yinghua Guo, Youhuan Zhong, Jungang Wang, Haotian Yang, Jie Zhao, Chunlei Guo, Yunxia Huang, Zuhai Lei, Yi-Lun Ying, Xiao Luo, Haolu Wang, Xuhong Qian, Wen Yang*, Xiaowen Liang* &Youjun Yang*, A Monochromophoric Approach to Succinct Ratiometric Fluorescent Probes Without Probe-Product Crosstalk, CCS Chemistry, 2020, In Press
7. Wen Yang et al. Mitochondrial Sirtuins Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks, Introductory Review on Sirtuins in Biology, Aging, and Disease, 2018, Pages 95-115
8. Wen Yang, Koji Nagasawa, Christian Münch, Yingjie Xu, Kyle Satterstrom, SeungminJeong, Sebastian D Hayes, Mark P. Jedrychowski, F. Sejal Kamlesh Vyas; Elma Zaganjor, Virginia Guarani, Alison Ringle, Steven P Gygi, J. Wade Harper, and Marcia C Haigis: Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-dependent Deacetylation in Response to Membrane Depolarization. Cell, 2016, 167(4): 985–1000.e21.
9. Xu Y, Yang W, Shi J, Zetter BR, Shi J.: Prohibitin 1 regulates tumor cell apoptosis via interaction with X-linked Inhibitor of Apoptosis Protein. J Mol Cell Biol, 2016, 8 (3): 282-285.
10. Callista Yee, Wen Yang, and Siegfried Hekimi.: The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell, 2014, 157(4):897-909
11. Inuzuka,H., Gao,D., Finley,L.W., Yang,W., Wan,L., Fukushima,H., Chin,Y.R., Zhai,B., Shaik,S., Lau,A.W., Wang,Z., Gygi,S.P., Nakayama,K., Teruya-Feldstein,J., Toker,A., Haigis,M.C., Pandolfi,P.P., and Wei,W.: Acetylation-dependent regulation of Skp2 function. Cell, 2012,150:179-193.
12. Hekimi S, Lapointe J, Yang W,: Taking a “good” look at free radicals in the aging process. Trends in Cell Biology, 2011, 67(1):1-8.
13. Yang W and Hekimi S: A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans. PLOS biology. 2010, 8(12):e1000556
14. Van Raamsdonk JM, Meng Y, Camp D, Yang W, Jia X, Bénard C, and Hekimi S: Decreased Energy Metabolism Extends Lifespan in Caenorhabditis elegans Without Reducing Oxidative Damage. Genetics. 2010, 185(2):559-71.
15. Yang W and Hekimi S: Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell. 2010, 9(3):433-47.
16. Yang W*, Li J*, Hekimi S: A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans. Genetics. 2007, 177(4):2063-74.
