何伶利
腫瘤代謝調(diào)控與靶向治療組
電話：021-63846590-776486
郵箱：[email protected]
研究方向
1. 揭示腫瘤細(xì)胞的代謝脆弱性：利用高通量篩選體系，結(jié)合相關(guān)生物學(xué)難題，鑒定和驗(yàn)證腫瘤細(xì)胞的代謝依賴性；并運(yùn)用多組學(xué)方法解析代謝分子的調(diào)控機(jī)制。
2. 開發(fā)小分子藥物：基于代謝靶點(diǎn)，結(jié)合前沿的藥物篩選和藥物設(shè)計(jì)技術(shù)，開發(fā)新型抗癌小分子，并推進(jìn)臨床應(yīng)用。
3. 聚焦硒蛋白的生理功能和調(diào)控機(jī)制：通過建立動(dòng)物疾病模型，研究硒蛋白在衰老、肥胖等慢性疾病中的功能和調(diào)控機(jī)制，以期解密硒蛋白與長壽之間的關(guān)系。
個(gè)人簡歷
何伶利研究員于中國科學(xué)院分子細(xì)胞科學(xué)卓越創(chuàng)新中心獲得博士學(xué)位，師從國家高層次人才張雷研究員，聚焦Hippo信號通路在組織穩(wěn)態(tài)維持和腫瘤發(fā)生發(fā)展中的功能和機(jī)制研究。隨后在哈佛大學(xué)造血干細(xì)胞領(lǐng)域鼻祖David Scadden院士實(shí)驗(yàn)室從事博士后研究，專注于造血系統(tǒng)和血液類疾病的研究。主要方向?yàn)檠芯考毙运柘蛋籽“l(fā)生和耐藥過程中的代謝脆弱性，并深入研究代謝相關(guān)的具體機(jī)制，聚焦于硒蛋白合成信號通路以及硒蛋白的功能研究，并利用多種創(chuàng)新方法進(jìn)行靶向小分子藥物的篩選。相關(guān)研究成果以第一作者或者共同第一作者發(fā)表在Blood, Cell Metabolism (under revision), Cancer Research, Cell Reports, eLife, Nanoscale, J Biol Chem等高質(zhì)量學(xué)術(shù)期刊。何伶利多次獲得哈佛大學(xué)Blavatnik Biomedical Accelerator的資助，榮獲2023年國際干細(xì)胞大會(huì)（ISSCR）的Merit Award，并擔(dān)任Nature Chemical Biology, Communications Biology 和Cancer Letters等多個(gè)國際學(xué)術(shù)期刊審稿人。何伶利研究員于2025年加入上海交通大學(xué)-醫(yī)學(xué)院-基礎(chǔ)醫(yī)學(xué)院-生物化學(xué)與分子細(xì)胞生物學(xué)系，成立“腫瘤代謝調(diào)控與靶向治療”課題組。
科研項(xiàng)目
論文與專著
1. He, L., Zhao, T., Leong, W.Z., Sharda, A., Mayerhofer, C., Mei, S., Bonilla, G.M., Menendez-Gonzalez, J.B., Gustafsson, K., Fukushima, T., et al. (2025). PSTK inhibition activates cGAS-STING, precipitating ferroptotic cell death in leukemic stem cells. Blood.
2. Zhao, T.*, He, L.*, Wong, L., Mei, S. Xu, Y., et al., and Scadden, D. T. De-repressing Nuclear Pyruvate Dehydrogenase Complex Reprograms Cancer Cells (Cell Metabolism, minor revision)
3. He, L., Yuan, L., Sun, Y., Wang, P., Zhang, H., et al., and Zhang L. (2019). Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression. Cancer Res 79, 4399-4411.
4. He, L. *, Yuan, L. *, Yu, W., Sun, Y., Jiang, D., et al. and Zhang L. (2020). A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis. Cell Rep 33, 108284.
5. Wang, J.*, Liu, C.*, He, L.*, Xie, Z., Bai, L., et al. and Zeng, Y. A. (2022). Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair. eLife 11.
6. Wu, M. *, Hu, L. *, He, L. *, Yuan, L., Yang, L., Zhao, B., Zhang, L., and He, X. (2024). The tumor suppressor NF2 modulates TEAD4 stability and activity in Hippo signaling via direct interaction. J Biol Chem 300.
7. He, L.#, Yu, W., Lu, Y., Zhang, W., Xu, J., and Zhang, L.# (2021). A protocol for in vivo analysis of liver tumorigenesis in mice using sleeping beauty transposon system. STAR Protocols 2, 100445.
8. He, L.#, Yu, W., Zhang, W., and Zhang, L.# (2021). An optimized two-step chromatin immunoprecipitation protocol to quantify the associations of two separate proteins and their common target DNA. STAR Protocols 2, 100504.
9. Gao, J.*, He, L.*, Shi, Y., Cai, M., Xu, H., Jiang, J., Zhang, L., and Wang, H. (2017). Cell contact and pressure control of YAP localization and clustering revealed by super-resolution imaging. Nanoscale 9, 16993-17003.
10. Fan, X.*, He, L.*, Meng, Y., Li, G., Li, L., and Meng, Y. (2015). Alpha-MMC and MAP30, two ribosome-inactivating proteins extracted from Momordica charantia, induce cell cycle arrest and apoptosis in A549 human lung carcinoma cells. Mol Med Rep 11, 3553-3558.
11. Gao, J., He, L., Zhou, L., Jing, Y., Wang, F., et al. and Wang, H. (2020). Mechanical force regulation of YAP by F-actin and GPCR revealed by super-resolution imaging. Nanoscale 12, 2703-2714.
12. Feng, X., Lu, T., Li, J., Yang, R., Hu, L., Ye, Y., Mao, F., He, L., et al., and Zhang L. (2020). The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice. Hepatology 71, 1988-2004.
13. Feng, X., Wang, Z., Wang, F., Lu, T., Xu, J., Ma, X., Li, J., He, L., et al. and Zhang L. (2019). Dual function of VGLL4 in muscle regeneration. EMBO J 38, e101051.
14. Zhang, W., Xu, J., Li, J., Guo, T., Jiang, D., Feng, X., Ma, X., He, L., et al. and Zhang L. (2018). The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex. J Biol Chem 293, 17119-17134.
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