曹克磊 助理研究員
郵箱: [email protected]
研究方向：
神經免疫調控
神經炎癥在精神疾病中的作用及機制
小膠質細胞在睡眠及麻醉中的調控機制
教育及工作經歷：
2011.09-2015.06；蚌埠醫(yī)學院,；學士
2015.09-2018.06； 南京醫(yī)科大學,；碩士
2018.09-2022.06,； 浙江大學；博士
2022.07-2024.08,；浙江大學,；博士后
論文發(fā)表
1. Kelei Cao#, Liyao Qiu#, Xuan Lu, Weiying Wu, Yaling Hu, Zhicheng Cui, Chao Jiang, Yuxiang Luo, Yujin Shao, Wang Xi, Ling-Hui Zeng, Han Xu, Huan Ma, Zhi Zhang, Jiyun Peng, Shumin Duan*, Zhihua Gao*. Microglia modulate general anesthesia through P2Y12 receptor. Current Biology. 2023 May 6: S0960-9822(23)00529-8. doi: 10.1016/j.cub.2023.04.047. (Commented by Science, and highlighted by Lab Animals).
2. Yaling Hu#; Kelei Cao# (Co-first author); Fang Wang#; Weiying Wu; Weihao Mai; Liyao Qiu; Yuxiang Luo; Wooping Ge; Binggui Sun; Ligen Shi; Junming Zhu; Jianmin Zhang; Zhiying Wu; Yicheng Xie; Shumin Duan*; Zhihua Gao*. Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity. Nature Metabolism. 2022, 4(12): 1756-1774. doi: 10.1038/s42255-022-00707-5. (Highlighted by Molecular Cell).
3. Kelei Cao; Liao Xiang; Jiahui Lu; Shu Yao; Fengjiao Wu; Xingxing Zhu; Dongyan Shi; Shuang Wen; Lixin Liu; Hong Zhou. IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation. Journal of Neuroinflammation, 2018, 15(1). doi: 10.1186/s12974-018-1169-6.
4. Kelei Cao, Yaling Hu, Zhihua Gao. Sense to Tune: Engaging Microglia with Dynamic Neuronal Activity. Neuroscience Bulletin. 2023 Mar;39(3):553-556. doi: 10.1007/s12264- 022-01010-9.
5. Kelei Cao, Yaling Hu, Zhihua Gao. Brain Macrophages: Close or Distant Relatives?Neuroscience Bulletin. 2021 Feb;37(2):278-280. doi: 10.1007/s12264-020-00595-3.
6. Yaling Hu#, Weihao Mai#, Lunhao Chen, Kelei Cao, Bin Zhang, Zhenjie Zhang, Yijun Liu, Huifang Lou, Shumin Duan, Zhihua Gao. mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP. GLIA. 2020 May;68(5):1031-1045. doi: 10.1002/glia.23760.
7. Lunhao Chen#, Yaling Hu#, Siyuan Wang#, Kelei Cao, Weihao Mai, Weilin Sha, Huan Ma, Ling-Hui Zeng, Zhen-Zhong Xu, Yong-Jing Gao, Shumin Duan, Yue Wang, Zhihua Gao. mTOR-neuropeptide Y signaling sensitizes nociceptors to drive neuropathic pain. JCI Insight. 2022 Nov 22;7(22): e159247. doi: 10.1172/jci.insight.159247.
8. Xuan Lu#, Lunhao Chen#, Chao Jiang#, Kelei Cao, Zhihua Gao, Yue Wang. Microglia and macrophages contribute to the development and maintenance of sciatica in lumbar disc herniation. Pain. 2023 Feb 1;164(2):362-374. doi: 10.1097/j.pain.0000000000002708.
9. Dongyan Shi#, Tongguan Tian#, Shu Yao, Kelei Cao, Xingxing Zhu, Mingshun Zhang, Shuang Wen, Longjun Li, Meiqing Shi, Hong Zhou. FTY720 attenuates behavioral deficits in a murine model of systemic lupus erythematosus. Brain Behavior Immunity. 2018 May;70 :293-304. doi: 10.1016/j.bbi.2018.03.009.
10. Yawei Zhao, Dongyan Shi, Kelei Cao, Fengjiao Wu, Xingxing Zhu, Shuang Wen, Qiang You, Keqi Zhang, Lixin Liu, Hong Zhou. Fingolimod targets cerebral endothelial activation to block leukocyte recruitment in the central nervous system. Journal of Leukocyte Biology. 2018 Jan;103(1):107-118. doi: 10.1002/JLB.3A0717-287R.
主持或參與基金項目
1. 獲第九屆中國科協(xié)“青年人才托舉工程”項目支持 (2023-2026),；
2. 主持國家自然青年科學基金 (32300793, 2024-2026),；
3. 主持浙江省自然科學基金探索項目(Y24C090012, 2024-2026);
4. 主持中國博士后科學基金面上項目(2022M6722774),；
5. 作為骨干成員參與國家自然科學基金面上項目3項,。
會議報告
1. 2024.09 中國神經科學年會“Neural-Immune Interactions in Health and Disease”
報告題目：The role of microglia in general anesthesia；匯報人:曹克磊
2. 2024.07 日本神經科學年會Travel Award
口頭報告題目: Diverse roles of microglia in the brain；匯報人:曹克磊
3. 2023.08 中國高原腦科學論壇
口頭報告題目: Microglia and general anesthesia；匯報人:曹克磊
4. 2023.09 長三角神經科學青年論壇
口頭匯報題目: Diverse roles of microglia in the brain；匯報人:曹克磊
5. 2023.11 浙江省第十一屆神經科學年會青年論壇
題目: Neuromodulation roles and intrinsic glucose metabolism characteristics of microglia ；匯報人:曹克磊
6. 2022.12 浙江大學腦與腦機融合前沿科學中心青年博士論壇
題目: Dual roles of hexokinase 2 in shaping microglial function by gating glycolytic flux and mitochondrial activity,；匯報人:曹克磊
專利
1. 高志華,，曹克磊，邱禮耀,，房麗麗，嚴敏,，陸軒,。P2Y12受體及其拮抗劑的用途,。發(fā)明專利（已提交）
2. 高志華，曹克磊,，邱禮耀，陸軒,，胡亞玲,，吳煒瀅,，彭吉云，段樹民,，房麗麗，嚴敏,。CSF1R受體及其抑制劑的用途。發(fā)明專利（已提交）
獲獎情況
2024.08 日本神經科學年會Travel Award；
2023.11 浙江省第十一屆神經科學年會青年博士論壇二等獎,；
2023.09 長三角神經科學青年論壇卓越博士后獎,；
2022.11 浙江大學腦與腦機融合前沿科學中心青年博士論壇優(yōu)秀獎.
當前位置：
