當(dāng)前位置：
王杰 研究員
研究方向：磁共振成像與病毒示蹤技術(shù)在麻醉與睡眠領(lǐng)域應(yīng)用
教育經(jīng)歷
2007-2009 耶魯大學(xué) 生物醫(yī)學(xué)工程 聯(lián)合培養(yǎng)博士
2004-2009 蘭州大學(xué)化學(xué)化工學(xué)院 博士
2000-2004 蘭州大學(xué)，化學(xué)，學(xué)士
工作經(jīng)歷
2024-至今 上海交通大學(xué)醫(yī)學(xué)院松江研究院 課題組長
2017-2024 中科院精密測量院,，研究員
2012-2017 中科院武漢物數(shù)所,，副研究員，
2009-2012 中科院武漢物數(shù)所,，助理研究員，
2010-2013 耶魯大學(xué) 博士后
王杰 研究員
課題組圍繞磁共振成像技術(shù)，系統(tǒng)整合光/藥理遺傳學(xué),、光纖鈣記錄、膜片鉗,、電生理等前沿神經(jīng)科學(xué)技術(shù)解析腦疾病的發(fā)生發(fā)展機(jī)制,，團(tuán)隊(duì)重點(diǎn)關(guān)注麻醉與失眠障礙等相關(guān)研究領(lǐng)域。具體包括以下三個(gè)研究內(nèi)容：
1）系統(tǒng)整合前沿神經(jīng)科學(xué)技術(shù)解決麻醉與失眠障礙的發(fā)生機(jī)制,，并探索失眠障礙的非藥物干預(yù)新療法,，為臨床應(yīng)用奠定基礎(chǔ)；
2）整合病毒示蹤建立基因編碼磁共振成像技術(shù),，實(shí)現(xiàn)特異類型細(xì)胞的活體全腦檢測,；
3）與臨床團(tuán)隊(duì)緊密合作，進(jìn)行人腦磁共振影像的數(shù)據(jù)深度挖掘(尤其是治療前后的對比分析),，旨在篩選失眠障礙及精神疾病的腦影像學(xué)特征及相應(yīng)的干預(yù)靶點(diǎn)腦區(qū),，為臨床推廣提供理論依據(jù)。
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Jinfeng Wu#, Kangguang Lin#, Weicong Lu , Wenjin Zou , Xiaoyue Li , Yarong Tan , Jingyu Yang , Danhao Zheng , Xiaodong Liu , Bess Yin-Hung Lam , Guiyun Xu , Kun Wang , Roger S,，McIntyre , Fei Wang , Kwok-Fai So , Jie Wang*;Enhancing Early Diagnosis of Bipolar Disorder in Adolescents through Multimodal Neuroimaging, Biol Psychiatry, 2024:S0006-3223(24)01485-9
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Jie Wang, Wenfeng Zhao, Huang Wang, Haixia Leng, Qing Xue, Mao Peng, Baoquan Min, Xiukun Jin, Liucen Tan, Keming Gao, Hongxing Wang*, Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder, General Psychiatry (IF:11.9), 2024;37:e101338.
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Xiaolin Liang#, Meng Gong#, Zhikai Wang#, Jie Wang#, Weiwei Guo#, Aoling Cai, Zhenye Yang, Xing Liu, Fuqiang Xu, Wei Xiong*, Chuanhai Fu*, Xiangting Wang*; LncRNA 1 TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination, Cell Discovery (IF:13.0), 2024;10(1):54.
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Weicong Lu#, Jinfeng Wu#, Robin Shao*, Wenjin Zou, Ruoxi Zhang, Xiaoyue Li, Jiehua Kong, Danhao Zheng, Xinhe Tian, Yanling Gao, Sonata Yau, Benjami Goldstein, Guiyun Xu, Kwok-Fai So, Jie Wang,* Kangguang Lin; Genetic and symptomatic risks associated with longitudinal brain morphometry in bipolar disorder, Nature Mental Health, 2024,，2, 209–217.
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Jinpiao Zhu#; Chang Chen#; Xiaodong Liu; Mengying He; Yuanyuan Fang; Li Wang, Junke Jia, Juan Guo; Ziyue Zhao; Chenyi Gao; Jingang He; Fuqiang Xu; Daqing Ma*; Jie Wang*; Zongze Zhang*，Cerebellar Purkinje cell firing promotes conscious recovery from anaesthesia state through coordinating neuronal communications with motor cortex,，Theranostics, 2024; 14(2):480-495
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Yuanyuan Qin#; Jinfeng Wu#; Tao Chen#; Jia Li; Guiling Zhang; Di Wu; Yiran Zhou; Ning Zheng; Aoling Cai; Qin Ning; Anne Manyande; Fuqiang Xu; Jie Wang*; Wenzhen Zhu*; Long-term micro-structure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations, Journal of Clinical Investigation, 2021, 131(8): e147329 .
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Mei Li#, Zhuang Liu#, Yang Wu, Ning Zheng, Xiaodong Liu, Aoling Cai, Danhao Zheng, Jinpiao Zhu, Jinfeng Wu, Lingling Xu, Xihai Li, Ling-Qiang Zhu, Anne Manyande, Fuqiang Xu*, Jie Wang*, In vivo Imaging of Astrocytes in the Whole Brain with Engineered AAVs and Diffusion Weighted Magnetic Resonance Imaging, Molecular Psychiatry, 2024;29(3):545-552
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Jinpiao Zhu#, Chang Chen#, Jinfeng Wu, Mengying He, Shuang Li, Yuanyuan Fang, Yan Zhou, Haibo Xu, Saeed Sadigh-Eteghad, Anne Manyande, Feng Zheng, Ting Chen, Fuqiang Xu, Daqing Ma, Jie Wang*, Zongze Zhang*, Propofol ameliorates social and anxiety-related behaviours through enhancing mPFC functional connectivity in the sleep-deprived rat: In comparison with sevoflurane, British Journal of Anaesthesia, 2023, 131(3): 531-541.
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Yaqing Shu#; Fuhua Peng#; Bingchu Zhao; Chunxin Liu; Qihui Li; Huilu Li; Yuge Wang; Yanjun Jiang; Tingting Lu; Qin Wang; Jian Sun; Huiyu Feng; Zhengqi Lu; Xiaodong Liu*; Jie Wang*; Wei Qiu*; Transfer of patient’s peripheral blood mononuclear cells (PBMCs) disrupts blood–brain barrier and induces anti-NMDAR encephalitis: a study of novel humanized PBMC mouse model, Journal of Neuroinflammation, 2023, 20: 164.
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Tian Tian#, Jinfeng Wu#, Tao Chen, Jia Li, Su Yan, Yiran Zhou, Xiaolong Peng, Yuanhao Li, Ning Zheng, Aoling Cai, Qin Ning, Hongbing Xiang, Fuqiang Xu, Yuanyuan Qin*, Wenzhen Zhu*, Jie Wang*, Long-term follow-up studies for dynamic brain changes in recovered COVID-19 patients without neurological manifestations. JCI insight, 2022, 7(4): e155827
