當前位置：
王杰 研究員
研究方向：磁共振成像與病毒示蹤技術(shù)在麻醉與睡眠領(lǐng)域應用
教育經(jīng)歷
2007-2009 耶魯大學 生物醫(yī)學工程 聯(lián)合培養(yǎng)博士
2004-2009 蘭州大學化學化工學院 博士
2000-2004 蘭州大學，化學，學士
工作經(jīng)歷
2024-至今 上海交通大學醫(yī)學院松江研究院 課題組長
2017-2024 中科院精密測量院，研究員
2012-2017 中科院武漢物數(shù)所，副研究員，
2009-2012 中科院武漢物數(shù)所，助理研究員，
2010-2013 耶魯大學 博士后
王杰 研究員
課題組圍繞磁共振成像技術(shù)，系統(tǒng)整合光/藥理遺傳學、光纖鈣記錄、膜片鉗、電生理等前沿神經(jīng)科學技術(shù)解析腦疾病的發(fā)生發(fā)展機制，團隊重點關(guān)注麻醉與失眠障礙等相關(guān)研究領(lǐng)域。具體包括以下三個研究內(nèi)容：
1）系統(tǒng)整合前沿神經(jīng)科學技術(shù)解決麻醉與失眠障礙的發(fā)生機制，并探索失眠障礙的非藥物干預新療法，為臨床應用奠定基礎；
2）整合病毒示蹤建立基因編碼磁共振成像技術(shù)，實現(xiàn)特異類型細胞的活體全腦檢測；
3）與臨床團隊緊密合作，進行人腦磁共振影像的數(shù)據(jù)深度挖掘(尤其是治療前后的對比分析)，旨在篩選失眠障礙及精神疾病的腦影像學特征及相應的干預靶點腦區(qū)，為臨床推廣提供理論依據(jù)。
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Jinfeng Wu#, Kangguang Lin#, Weicong Lu , Wenjin Zou , Xiaoyue Li , Yarong Tan , Jingyu Yang , Danhao Zheng , Xiaodong Liu , Bess Yin-Hung Lam , Guiyun Xu , Kun Wang , Roger S，McIntyre , Fei Wang , Kwok-Fai So , Jie Wang*;Enhancing Early Diagnosis of Bipolar Disorder in Adolescents through Multimodal Neuroimaging, Biol Psychiatry, 2024:S0006-3223(24)01485-9
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Jie Wang, Wenfeng Zhao, Huang Wang, Haixia Leng, Qing Xue, Mao Peng, Baoquan Min, Xiukun Jin, Liucen Tan, Keming Gao, Hongxing Wang*, Brain-wide activation involved in 15 mA transcranial alternating current stimulation in patients with first-episode major depressive disorder, General Psychiatry (IF:11.9), 2024;37:e101338.
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Xiaolin Liang#, Meng Gong#, Zhikai Wang#, Jie Wang#, Weiwei Guo#, Aoling Cai, Zhenye Yang, Xing Liu, Fuqiang Xu, Wei Xiong*, Chuanhai Fu*, Xiangting Wang*; LncRNA 1 TubAR complexes with TUBB4A and TUBA1A to promote microtubule assembly and maintain myelination, Cell Discovery (IF:13.0), 2024;10(1):54.
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Weicong Lu#, Jinfeng Wu#, Robin Shao*, Wenjin Zou, Ruoxi Zhang, Xiaoyue Li, Jiehua Kong, Danhao Zheng, Xinhe Tian, Yanling Gao, Sonata Yau, Benjami Goldstein, Guiyun Xu, Kwok-Fai So, Jie Wang,* Kangguang Lin; Genetic and symptomatic risks associated with longitudinal brain morphometry in bipolar disorder, Nature Mental Health, 2024，2, 209–217.
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Jinpiao Zhu#; Chang Chen#; Xiaodong Liu; Mengying He; Yuanyuan Fang; Li Wang, Junke Jia, Juan Guo; Ziyue Zhao; Chenyi Gao; Jingang He; Fuqiang Xu; Daqing Ma*; Jie Wang*; Zongze Zhang*，Cerebellar Purkinje cell firing promotes conscious recovery from anaesthesia state through coordinating neuronal communications with motor cortex，Theranostics, 2024; 14(2):480-495
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Yuanyuan Qin#; Jinfeng Wu#; Tao Chen#; Jia Li; Guiling Zhang; Di Wu; Yiran Zhou; Ning Zheng; Aoling Cai; Qin Ning; Anne Manyande; Fuqiang Xu; Jie Wang*; Wenzhen Zhu*; Long-term micro-structure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations, Journal of Clinical Investigation, 2021, 131(8): e147329 .
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Mei Li#, Zhuang Liu#, Yang Wu, Ning Zheng, Xiaodong Liu, Aoling Cai, Danhao Zheng, Jinpiao Zhu, Jinfeng Wu, Lingling Xu, Xihai Li, Ling-Qiang Zhu, Anne Manyande, Fuqiang Xu*, Jie Wang*, In vivo Imaging of Astrocytes in the Whole Brain with Engineered AAVs and Diffusion Weighted Magnetic Resonance Imaging, Molecular Psychiatry, 2024;29(3):545-552
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Jinpiao Zhu#, Chang Chen#, Jinfeng Wu, Mengying He, Shuang Li, Yuanyuan Fang, Yan Zhou, Haibo Xu, Saeed Sadigh-Eteghad, Anne Manyande, Feng Zheng, Ting Chen, Fuqiang Xu, Daqing Ma, Jie Wang*, Zongze Zhang*, Propofol ameliorates social and anxiety-related behaviours through enhancing mPFC functional connectivity in the sleep-deprived rat: In comparison with sevoflurane, British Journal of Anaesthesia, 2023, 131(3): 531-541.
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Yaqing Shu#; Fuhua Peng#; Bingchu Zhao; Chunxin Liu; Qihui Li; Huilu Li; Yuge Wang; Yanjun Jiang; Tingting Lu; Qin Wang; Jian Sun; Huiyu Feng; Zhengqi Lu; Xiaodong Liu*; Jie Wang*; Wei Qiu*; Transfer of patient’s peripheral blood mononuclear cells (PBMCs) disrupts blood–brain barrier and induces anti-NMDAR encephalitis: a study of novel humanized PBMC mouse model, Journal of Neuroinflammation, 2023, 20: 164.
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Tian Tian#, Jinfeng Wu#, Tao Chen, Jia Li, Su Yan, Yiran Zhou, Xiaolong Peng, Yuanhao Li, Ning Zheng, Aoling Cai, Qin Ning, Hongbing Xiang, Fuqiang Xu, Yuanyuan Qin*, Wenzhen Zhu*, Jie Wang*, Long-term follow-up studies for dynamic brain changes in recovered COVID-19 patients without neurological manifestations. JCI insight, 2022, 7(4): e155827
