當(dāng)前位置：
孫蓮慧 青年研究員
研究方向：細(xì)胞代謝與腫瘤免疫
教育經(jīng)歷
2009-2015年 華東師范大學(xué)生命醫(yī)學(xué)研究所，博士
2005-2009年 臨沂大學(xué)生命與科學(xué)學(xué)院，學(xué)士
工作經(jīng)歷
2025年-至今 上海交通大學(xué)醫(yī)學(xué)院松江研究院，青年研究員
2024-2025年 上海交通大學(xué)醫(yī)學(xué)院附屬第一人民醫(yī)院，副研究員
2015-2024年 上海交通大學(xué)醫(yī)學(xué)院附屬第一人民醫(yī)院，助理研究員
課題組長簡介：
孫蓮慧，獨(dú)立PI，青年研究員，碩導(dǎo)。2015年博士畢業(yè)于華東師范大學(xué)生命醫(yī)學(xué)研究所，同年入職上海交通大學(xué)醫(yī)學(xué)院附屬第一人民醫(yī)院臨床轉(zhuǎn)化研究院，于2025年03月入職上海交通大學(xué)醫(yī)學(xué)院松江研究院/上海交通大學(xué)細(xì)胞與基因治療研究院。研究方向聚焦于腦腫瘤或腦轉(zhuǎn)移瘤相關(guān)的腫瘤類型，圍繞細(xì)胞代謝與腫瘤免疫微環(huán)境調(diào)控分子機(jī)制，提出腫瘤治療新靶點(diǎn)、新策略、新方法。研究成果以第一或通訊（含共同）作者在Nature Communications (4篇)、Current Biology (Nature Review專評文章)、Cell Reports、Advanced Science（封面雜志）等期刊發(fā)表多篇研究論文，獲得國家發(fā)明專利3項(xiàng)。主持國家自然科學(xué)基金青年項(xiàng)目、面上項(xiàng)目，入選上海市揚(yáng)帆計(jì)劃，山東省泰山學(xué)者青年專家項(xiàng)目等。現(xiàn)任北京慢性病防治與健康教育研究會(huì)委員、Exploration雜志青年編委。
孫蓮慧 青年研究員
實(shí)驗(yàn)室聚焦于腦腫瘤或腦轉(zhuǎn)移瘤相關(guān)的腫瘤類型，如膠質(zhì)母細(xì)胞瘤、肺癌腦轉(zhuǎn)移瘤、乳腺癌腦轉(zhuǎn)移瘤等，圍繞細(xì)胞代謝與腫瘤免疫微環(huán)境調(diào)控分子機(jī)制，提出腫瘤治療新靶點(diǎn)、新策略、新方法，并致力于開發(fā)腫瘤早篩技術(shù)、腫瘤耐藥復(fù)發(fā)的新分子標(biāo)志物的轉(zhuǎn)化及應(yīng)用。
方向一：圍繞蛋白質(zhì)翻譯后修飾，研究與細(xì)胞代謝異常相關(guān)的蛋白質(zhì)功能及其調(diào)控，揭示其生理和病理意義。
方向二：圍繞腫瘤細(xì)胞與免疫微環(huán)境調(diào)控的信號分子通路，研究腫瘤免疫微環(huán)境重塑的機(jī)制。
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1. Xiadi He, Qiwei Wang, Xin Cheng, Weihua Wang, Yutong Li, Yabing Nan, Jiang Wu, Bingqiu Xiu, Tao Jiang, Johann S. Bergholz, Hao Gu, Fuhui Chen, Guangjian Fan, Lianhui Sun, Shaozhen Xie, Junjie Zou, Sheng Lin, Yun Wei, James Lee, John M. Asara, Ke Zhang, Lewis C. Cantley, and Jean J. Zhao. Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response. Cell, 2025, 188, 1-20.
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2. Lianhui Sun#, Guangjian Fan#, Zhuqing Zhang#, Dong Chang, Xiaoyu Zhang, Tongqing Zhang, Jichuan Geng, Xiaoxia Zhang, Menghan Lin, Chen Hu, Jiaqi Zhou, Mengxue Wang, Liu Cao, Mary Zhang, Baokun He, Shengping Zhang* and Chuangui Wang*. Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy. Cell Reports, 2025, 44, 115269.
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3. Boyu Yang#, Shiyun Liu#, Tianming Cheng#, Xijian Liu, Jian Song, Xuanhao Li, Fangzhou Zhao, Jingcheng Lv, Meishan Zhao, Mingjun Shi, Jun Li, Yanchun Quan, Guangjian Fan*, Song Guo Zheng*, Bangmin Han*, Lianhui Sun*. Combination of porous Se@SiO2 nanospheres and docetaxel exhibits anti-castration-resistant prostate cancer activity by downregulating ATG14-dependent autophagy. Nano Today, 59 (2024) 102499.
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4. Jian Chen#, Deping Zhao#, Yupeng Wang#, Ming Liu, Yuan Zhang, Tingting Feng, Chao Xiao, Huan Song, Rui Miao, Li Xu, Hongwei Chen, Xiaoying Qiu, Yi Xu, Jingxuan Xu, Zelin Cui, Wei Wang, Yanchun Quan, Yifeng Zhu, Chen Huang, Song Guo Zheng, Jianyuan Zhao*, Ting Zhu*, Lianhui Sun*, Guangjian Fan *. Lactylated Apolipoprotein C-II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis. Advanced Science, 2024.2406333.
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5. Lianhui Sun#, Yuan Zhang#, Boyu Yang#, Simiao Sun, Pengshan Zhang, Zai Luo, Tingting Feng, Zelin Cui, Ting Zhu, Yuming Li, Zhengjun Qiu, Guanjian Fan*, and Huang Chen*. Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer. Nature Communications, 2023 Oct 14:6523.
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6. Lianhui Sun#, Xing Wang#, Lixiao Chen#, Zheng Gao, Songhui Xu, Chen Hu, Guangjian Fan, Baoxin Wang, Tingting Feng*, Wang Wang*, Xinjiang Ying*. CPT1A mediates chemoresistance in human hypopharyngeal squamous cell carcinoma via ATG16L1-dependent cellular autophagy. Cell insight, 2023. Oct 11;2(6):100127.
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7. Lei Chen, Minglei Sha, Feiteng Chen, Chenyi Jiang, Deng Li, Chaoliang Xu, Deshen Pan, Zijie Xu, Qilin Tang, Shujie Xia, Lianhui Sun*, Guangjian Fan*, Yi Shao*. Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARα-mediated fatty acid oxidation. Free Radic Bio Med. 2021 Feb 1; 195:132-144.
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8. Guangjian Fan#, Lianhui Sun#, Ling Meng #, Chen Hu, Xing Wang, Zhan Shi, Congli Hu, Yang Han, Qingqing Yang, Liu Cao, Xiaohong Zhang, Yan Zhang, Xianmin Song, Shujie Xia, Baokun He, Shengping Zhang*, Chuangui Wang*. The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation. Nature Communications. (2021) 12: 20.
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9. Jin Cheng#, Sijia He#, Min Wang, Ling Zhou, Zhengxiang Zhang, Xiao Feng, Yang Yu, Jingjing Ma, Chenyun Dai, Shengping Zhang, Lianhui Sun, Yanping Gong, Yiwei Wang, Minghui Zhao, Yuntao Luo, Xinjian Liu, Ling Tian, Chuanyuan Li*, Qian Huang*. Caspase-3/PKCδ/Akt/VEGF-A Signaling Pathway Mediates Tumor Repopulation during Radiotherapy. Clinical Cancer Research, 2019 Mar 19; 18:3001.
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10. Sijia He#, Jin Cheng#, Lianhui Sun#, Yiwei Wang, Chuangui Wang, Xinjian Liu, Zhengxiang Zhang, Minghui Zhao, Yuntao Luo, Ling Tian*, Chuanyuan Li*and Qian Huang*. HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect. Cell Death and Disease. 2018 May 29; 9:648.
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11. Peipei Shan#, Guangjian Fan#, Lianhui Sun#, Jinqin Liu, Weifang Wang, Chen Hu, Xiaohong Zhang, Qiwei Zhai, Xiaoyu Song, Liu Cao, Yongping Cui, Shengping Zhang* and Chuangui Wang*. SirT1 functions as a master regulator of poly (A) RNA transport under stress conditions. Current biology. 2017 Aug 7; 27:1-14.
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12. Lianhui Sun#, Guangjian Fan#, Peipei Shan#, Xiaoying Qiu, Shuxian Dong, Lujian Liao, Chunlei Yu, Tingting Wang, Xiaoyang Gu, Qian Li, Xiaoyu Song, Liu Cao, Xiaotao Li, Yongping Cui, Shengping Zhang* and Chuangui Wang*. Regulation of energy homeostasis by the ubiquitin-independent REGγ proteasome. Nature Communications, 2016 Aug 11; 7:12497.
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13. Guangjian Fan#, Lianhui Sun#, Peipei Shan#, Xianying Zhang, Jinliang Huan, Xiaohong Zhang, Dali Li, Tingting Wang, Tingting Wei, Xiaohong Zhang, Xiaoyang Gu, Liangfang Yao, Yang Xuan, Zhaoyuan Hou, Yongping Cui, Liu Cao, Xiaotao Li, Shengping Zhang* and Chuangui Wang*. Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nature Communications, 2015 Oct 6; 6:8450.
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14. Shuxian Dong#, Caifeng Jia#, Shengping Zhang#, Guangjian Fan, Yubing Li, Peipei Shan, Lianhui Sun, Wenzhen Xiao, Lei Li, Yi Zheng, Jinqin Liu, Haibing Wei, Chen Hu, Wen Zhang, Y. Eugene Chin, Qiwei Zhai, Qiao Li, Jian Liu, Fuli Jia, Qianxing Mo, Dean P. Edwards, Shixia Huang, Lawrence Chan, Bert W. O’Malley, Xiaotao Li*, and Chuangui Wang*. The REGγ Proteasome Regulates Hepatic Lipid Metabolism through Inhibition of Autophagy. Cell Metabolism, 2013 Sep 3;18(3):380-91.
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15. Shibiao Wu, Jingjing Su, Lianhui Sun, Wenxuan Wang, Yun Zhao, Hui Li, Shengping Zhang, Guanghui Dai, Chuangui Wang, and Jinfeng Hu. Triterpenoids and Steroids from the Fruits of Melia toosendan and Their Cytotoxic Effects on Two Human Cancer Cell Lines. J Nat Prod. 2010 Nov 29;73 (11):1898-906.