當(dāng)前位置：
張亮 教授
研究方向：腦白質(zhì)發(fā)育與疾病
教育經(jīng)歷
2003 年，武漢大學(xué)，學(xué)士學(xué)位；
2008年，中科院分子細(xì)胞科學(xué)卓越創(chuàng)新中心（原上海生化細(xì)胞所），博士學(xué)位；
工作經(jīng)歷
2024年1月至今，上海交通大學(xué)醫(yī)學(xué)院松江研究院，教授；
2014-2024年，廈門大學(xué)生命科學(xué)學(xué)院，副教授/教授；
2009-2014年，美國(guó)西南醫(yī)學(xué)中心，博士后。
課題組組長(zhǎng)簡(jiǎn)介
張亮博士，研究員，獨(dú)立PI，博士生導(dǎo)師。主要從事神經(jīng)膠質(zhì)細(xì)胞和腦白質(zhì)相關(guān)研究，近年來以通訊/共同通訊作者身份在Neuron (2篇)、Developmental Cell (2篇)、Journal of Clinical Investigation、Nature Communications、Cell Reports等學(xué)術(shù)刊物上發(fā)表論文,并被Faculty1000，Neuron，Nature Reviews Neuroscience，科技日?qǐng)?bào)等專業(yè)或大眾媒體推薦及評(píng)價(jià)。獲得國(guó)家自然科學(xué)基金區(qū)域創(chuàng)新聯(lián)合基金重點(diǎn)項(xiàng)目，面上項(xiàng)目等資助，并協(xié)助課題組博士研究生獲得省優(yōu)秀博士論文，博士后創(chuàng)新人才計(jì)劃等榮譽(yù)和資助。
張亮 教授
中樞神經(jīng)系統(tǒng)腦白質(zhì)發(fā)育不良或腦白質(zhì)損傷是腦癱、缺氧缺血性腦病及多發(fā)性硬化癥等神經(jīng)疾病的主要致病因素。這個(gè)損傷過程涉及了神經(jīng)細(xì)胞發(fā)育與再生和細(xì)胞應(yīng)激等生物學(xué)機(jī)制。我們重點(diǎn)關(guān)注神經(jīng)發(fā)育和損傷再生過程中細(xì)胞可塑性的改變，發(fā)現(xiàn)并理解在這些過程中的關(guān)鍵調(diào)節(jié)基因及作用機(jī)制，探索促進(jìn)腦白質(zhì)發(fā)育和損傷修復(fù)的策略，并試圖揭示腦白質(zhì)在腦功能和重大腦疾病中的功能和作用機(jī)制。
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Wenxiu Dai#, Zhixiong Liu#, Minbiao Yan, Ximing Nian, Fan Hong, Zhihao Zhou, Chaomeng Wang, Xing Fu, Xuewen Li, Mengyun Jiang, Yanqin Zhu, Qiuying Huang, Xiaoyun Lu, Lichao Hou, Ning Yan, Qin Wang, Jin Hu, Wei Mo, Xueqin Zhang, Liang Zhang*(2024). Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells, Developmental Cell Jan 24
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Li Li#, Daopeng Li#, Di Sun#, Xueqin Zhang#, Wanying Lei, Mei Wu, Qiuying Huang, Ximing Nian, Wenxiu Dai, Xiaoyun Lu, Zhihao Zhou, Yanqin Zhu, Yunshan Xiao, Ling Zhang, Wei Mo, Zhixiong Liu, and Liang Zhang* (2023). Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination, Developmental Cell Oct 17:S1534-5807(23)00489-6
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Wu M#; Li M#; Liu W#; Yan MB; Li L; Ding WC; Nian XM; Dai WX; Sun D; Zhu YQ; Huang QY; Lu XY; Cai ZY; Hong F; Li XW; Zhang L; Liu ZX; Mo W; Zhang XQ; Zhang L* (2023). Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis. Cell Rep 42, 112802.
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Hu J#*; Chen Q#; Zhu HR#; Hou LC#; Liu W; Yang QH; Shen HD; Chai GL; Zhang BX; Chen SX; Cai ZY; Wu CX; Hong F; Li HD; Chen SF; Xiao NA; Wang ZX; Zhang XQ; Wang B; Zhang L*; Mo W* (2023). Microglial Piezo1 senses Aβ fibrils stiffness to restrict Alzheimer’s disease. Neuron 111,1-15. (Best of Neuron 2022-2023 and Highlighted by Neuron)
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Liu ZX #; Yan MB#; Lei WY#; Jiang RC; Dai WX; Chen JL; Wang CM; Li L; Wu M; Nian XM; Li DP; Sun D; Lv XY; Wang CY; Xie CC; Yao LM; Wu CM; Hu J; Xiao NA; Mo W; Wang ZX* and Zhang L* (2022). Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling. J Clin Invest 132(7): e155096.
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Zhang KK #; Chen SX#; Yang QH; Guo SH; Chen Q; Liu ZX; Li L; Jiang MY; H. Li HD; Hu J; Pan X; Deng WB; Xiao NA; Wang B; Wang ZX*; Zhang L* and W. Mo* (2022). The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents. Nat Commun 13: 1423.
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Liu ZX #; Yan MB#; Liang YJ#; Liu M; Zhang K; Shao DD; Jiang RC; Li L; Wang CM; Nussenzveig D; Zhang KK; Chen SX; Zhong CQ; Mo W; Fontoura B; Zhang L* (2019). Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination. Neuron 102: 587-601 (Highlighted by Neuron and Faculty1000)
