郵箱：[email protected]
研究方向：細胞死亡,，炎癥和自吞噬
教育背景
2005/09 –2009/07 成都理工大學(xué)學(xué)士學(xué)位
2009/09 –2012/07 中國科學(xué)院植物研究所碩士學(xué)位
工作經(jīng)歷
2012/07-2016/03 中國科學(xué)院生物與化學(xué)交叉研究中心 研究助理 導(dǎo)師：袁鈞瑛教授
2016/08-2018/08 哈佛醫(yī)學(xué)院波士頓兒童醫(yī)院 研究助理II 導(dǎo)師：Leslie Silberstein 教授
2018/08-2019/05 哈佛醫(yī)學(xué)院波士頓兒童醫(yī)院 研究助理III 導(dǎo)師：Leslie Silberstein 教授
2019/05-2021/09 哈佛醫(yī)學(xué)院波士頓兒童醫(yī)院 研究技術(shù)專家 導(dǎo)師：Leslie Silberstein 教授
2021/09-2023/04 哈佛醫(yī)學(xué)院波士頓兒童醫(yī)院 實驗室研究主管 導(dǎo)師：董民 教授
2023/05-至今 上海交通大學(xué)醫(yī)學(xué)院松江研究院 助理研究員
代表性論文
1.Manion J, Musser MA, Kuziel GA, Liu M (劉敏,，共同第二作者), Shepherd A, Wang S, Lee PG, Zhao L, Zhang J, Marreddy RKR, Goldsmith JD, Yuan K, Hurdle JG, Gerhard R, Jin R, Rakoff-Nahoum S, Rao M, Dong M. C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation. Nature. 2023 Sep 12. doi: 10.1038/s41586-023-06607-2.
2.Zhang T#, Xu D#,*, Trefts E#, Lv M#, Inuzuka H, Song G, Liu M (劉敏，第四作者), Lu J, Liu J, Chu C, Wang M, Wang H, Meng H, Liu H, Zhuang Y, Xie X, Dang F, Guan D, Men Y, Jiang S, Jiang C, Dai X, Liu J, Wang Z, Yan P, Wang J, Tu Z, Babuta M, Erickson E, Hillis AL, Dibble CC, Asara JM, Szabo G, Sicinski P, Miao J, Lee YR, Pan L*, Shaw RJ*, Yuan J*, Wei W*. Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. Science. 2023 Jun 30;380(6652):1372-1380.
3.Zhang T#, Xu D#,*, Liu J#, Wang M#, Duan LJ, Liu M (劉敏,，第三作者), Meng H, Zhuang Y, Wang H, Wang Y, Lv M, Zhang Z, Hu J, Shi L, Guo R, Xie X, Liu H, Erickson E, Wang Y, Yu W, Dang F, Guan D, Jiang C, Dai X, Inuzuka H, Yan P, Wang J, Babuta M, Lian G, Tu Z, Miao J, Szabo G, Fong GH, Karnoub AE, Lee YR, Pan L, Kaelin WG Jr, Yuan J*, Wei W*. Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation. Nature Cell Biology. 2023 Jul;25(7):950-962.
4.Tian S, Xiong X, Zeng J, Wang S, Tremblay BJ, Chen P, Chen B, Liu M (劉敏), Chen P, Sheng K, Zeve D, Qi W, Breault DT, Rodríguez C, Gerhard R, Jin R, Doxey AC, Dong M. Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants. Nature Communications. 2022 Nov 9;13(1):6786.
5.Park S, Matte A, Jung Y, Ryu J, Anand W, Han E, Liu M (劉敏), Carbone C, Melisi D, Nagasawa T, Locascio J, Lin C, Silberstein L, Franceschi L. Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion. Blood. 2020 Jun 4;135(23):2071-2084
6.Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M (劉敏), Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi P, Li H, Yu Q and Yuan J. G-protein Coupled Receptors Regulate Autophagy by ZBTB16-mediated Ubiquitination and Proteasomal Degradation of Adaptor Protein Atg14L. eLIFE, 2015
7.Xu D, Shan B#, Lee B, Zhu K, Zhang T#, Sun H, Liu M (劉敏), Shi L, Liang W, Qian L, Xiao J, Wang L, Pan L, Finley D, Yuan J. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. eLIFE, 2015.
8.Xiao J, Zhang T, Xu D, Wang H, Cai Y, Jin T, Liu M (劉敏), Liu M, Jin M, Wu K, Yuan J. FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation. Genes Development. 2015 Jan 15;29(2):184-96.
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