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梁偉 博士后

郵箱：[email protected]

研究方向：細(xì)胞死亡和炎癥在人類疾病中的作用

教育經(jīng)歷：

2009年9月---2013年6月? 沈陽(yáng)藥科大學(xué) 本科

2013年6月---2019年12月 中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所 博士

工作經(jīng)歷

2020年1月---2021年10月? 中國(guó)科學(xué)院上海有機(jī)化學(xué)研究所 科研助理

2021年11月---2024年11月 上海奕拓醫(yī)藥科技有限公司 研發(fā)副主任I

發(fā)表文章

1: Liang W, Qi W, Geng Y, Wang L, Zhao J, Zhu K, Wu G, Zhang Z, Pan H, Qian L,Yuan J. Necroptosis activates UPR sensors without disrupting their binding with GRP78. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39): e2110476118. doi:10.1073/pnas.2110476118. PMID: 34544877; PMCID: PMC8488584.

2: Liang W, Yuan J. Visualizing Endogenous Necrosomes in Necrosomes by In Situ Proximity Ligation Assay. Curr Protoc. 2022 Feb;2(2): e388. doi:10.1002/cpz1.388. PMID: 35195947.

3: Wu G, Li D, Liang W, Sun W, Xie X, Tong Y, Shan B, Zhang M, Lu X, Yuan J, LiY. PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIP to promote TNFα-mediated cell death. Cell Death Dis. 2022 Sep7;13(9):773. doi: 10.1038/s41419-022-05206-9. PMID: 36071040; PMCID: PMC9452587.

4: Zhu K, Liang W, Ma Z, Xu D, Cao S, Lu X, Liu N, Shan B, Qian L, Yuan J.Necroptosis promotes

cell-autonomous activation of proinflammatory cytokine gene expression. Cell Death Dis.2018 May 1;9(5):500. doi: 10.1038/s41419-018-0524-y. PMID: 29703889; PMCID: PMC5923285.

5: Li X, Zhang M, Huang X, Liang W, Li G, Lu X, Li Y, Pan H, Shi L, Zhu H, Qian L, Shan B, Yuan J. Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners. Nat Commun. Dec11;11(1):6364. doi: 10.1038/s41467-020-19935-y. PMID: 33311474; PMCID: PMC7733462.

6: Xu D, Shan B, Sun H, Xiao J, Zhu K, Xie X, Li X, Liang W, Lu X, Qian L, YuanJ. USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1. Genes Dev. 2016 Aug 1;30(15):1718-30. doi: 10.1101/gad.285122.116. PMID:27542828; PMCID: PMC5002977.

7: Zu R, Yu Z, Zhao J, Lu X, Liang W, Sun L, Si C, Zhu K, Zhang T, Li G, Zhang M, Zhang Y, Liu N, Yuan J, Shan B. Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production. Cell Death Dis. 2021 Oct 23;12(11):994. doi:10.1038/s41419-021-04290-7. PMID: 34689152; PMCID: PMC8542044.

8: Zhang T, Dong K, Liang W, Xu D, Xia H, Geng J, Najafov A, Liu M, Li Y, Han X, Xiao J, Jin Z, Peng T, Gao Y, Cai Y, Qi C, Zhang Q, Sun A, Lipinski M, Zhu H, Xiong Y, Pandolfi PP, Li H, Yu Q, Yuan J. G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. Elife. 2015 Mar 30;4:e06734. doi: 10.7554/eLife.06734. PMID: 25821988; PMCID: PMC4421748.

9: Xu D, Shan B, Lee BH, Zhu K, Zhang T, Sun H, Liu M, Shi L, Liang W, Qian L,Xiao J, Wang L, Pan L, Finley D, Yuan J. Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system. Elife. 2015 Nov 2;4:e10510. doi: 10.7554/eLife.10510. PMID: 26523394; PMCID: PMC4733041